98,080 research outputs found
Synthetic Observational Health Data with GANs: from slow adoption to a boom in medical research and ultimately digital twins?
After being collected for patient care, Observational Health Data (OHD) can
further benefit patient well-being by sustaining the development of health
informatics and medical research. Vast potential is unexploited because of the
fiercely private nature of patient-related data and regulations to protect it.
Generative Adversarial Networks (GANs) have recently emerged as a
groundbreaking way to learn generative models that produce realistic synthetic
data. They have revolutionized practices in multiple domains such as
self-driving cars, fraud detection, digital twin simulations in industrial
sectors, and medical imaging.
The digital twin concept could readily apply to modelling and quantifying
disease progression. In addition, GANs posses many capabilities relevant to
common problems in healthcare: lack of data, class imbalance, rare diseases,
and preserving privacy. Unlocking open access to privacy-preserving OHD could
be transformative for scientific research. In the midst of COVID-19, the
healthcare system is facing unprecedented challenges, many of which of are data
related for the reasons stated above.
Considering these facts, publications concerning GAN applied to OHD seemed to
be severely lacking. To uncover the reasons for this slow adoption, we broadly
reviewed the published literature on the subject. Our findings show that the
properties of OHD were initially challenging for the existing GAN algorithms
(unlike medical imaging, for which state-of-the-art model were directly
transferable) and the evaluation synthetic data lacked clear metrics.
We find more publications on the subject than expected, starting slowly in
2017, and since then at an increasing rate. The difficulties of OHD remain, and
we discuss issues relating to evaluation, consistency, benchmarking, data
modelling, and reproducibility.Comment: 31 pages (10 in previous version), not including references and
glossary, 51 in total. Inclusion of a large number of recent publications and
expansion of the discussion accordingl
Maximizing Enrollment for Kids: Results From a Diagnostic Assessment of Enrollment and Retention in Eight States
Examines strengths, challenges, and areas for improvement in Medicaid and Children's Health Insurance Plan enrollment and retention systems, policies, and procedures for children in eight grantee states. Outlines best practices in simplifying processes
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Generating monologue and dialogue to present personalised medical information to patients
Portinari: A Data Exploration Tool to Personalize Cervical Cancer Screening
Socio-technical systems play an important role in public health screening
programs to prevent cancer. Cervical cancer incidence has significantly
decreased in countries that developed systems for organized screening engaging
medical practitioners, laboratories and patients. The system automatically
identifies individuals at risk of developing the disease and invites them for a
screening exam or a follow-up exam conducted by medical professionals. A triage
algorithm in the system aims to reduce unnecessary screening exams for
individuals at low-risk while detecting and treating individuals at high-risk.
Despite the general success of screening, the triage algorithm is a
one-size-fits all approach that is not personalized to a patient. This can
easily be observed in historical data from screening exams. Often patients rely
on personal factors to determine that they are either at high risk or not at
risk at all and take action at their own discretion. Can exploring patient
trajectories help hypothesize personal factors leading to their decisions? We
present Portinari, a data exploration tool to query and visualize future
trajectories of patients who have undergone a specific sequence of screening
exams. The web-based tool contains (a) a visual query interface (b) a backend
graph database of events in patients' lives (c) trajectory visualization using
sankey diagrams. We use Portinari to explore diverse trajectories of patients
following the Norwegian triage algorithm. The trajectories demonstrated
variable degrees of adherence to the triage algorithm and allowed
epidemiologists to hypothesize about the possible causes.Comment: Conference paper published at ICSE 2017 Buenos Aires, at the Software
Engineering in Society Track. 10 pages, 5 figure
Intuitive querying of e-Health data repositories
At the centre of the Clinical e-Science Framework (CLEF) project is a repository of well organised, detailed clinical histories, encoded as data that will be available for use in clinical care and in-silico medical experiments. An integral part of the CLEF workbench is a tool to allow biomedical researchers and clinicians to query – in an intuitive way – the repository of patient data. This paper describes the CLEF query editing interface, which makes use of natural language generation techniques in order to alleviate some of the problems generally faced by natural language and graphical query interfaces. The query interface also incorporates an answer renderer that dynamically generates responses in both natural language text and graphics
Synthetic Data Generation using Benerator Tool
Datasets of different characteristics are needed by the research community
for experimental purposes. However, real data may be difficult to obtain due to
privacy concerns. Moreover, real data may not meet specific characteristics
which are needed to verify new approaches under certain conditions. Given these
limitations, the use of synthetic data is a viable alternative to complement
the real data. In this report, we describe the process followed to generate
synthetic data using Benerator, a publicly available tool. The results show
that the synthetic data preserves a high level of accuracy compared to the
original data. The generated datasets correspond to microdata containing
records with social, economic and demographic data which mimics the
distribution of aggregated statistics from the 2011 Irish Census data.Comment: 12 pages, 5 figures, 10 reference
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