Visualizing dimensionality reduction of systems biology data

One of the challenges in analyzing high-dimensional expression data is the detection of important biological signals. A common approach is to apply a dimension reduction method, such as principal component analysis. Typically, after application of such a method the data is projected and visualized in the new coordinate system, using scatter plots or profile plots. These methods provide good results if the data have certain properties which become visible in the new coordinate system and which were hard to detect in the original coordinate system. Often however, the application of only one method does not suffice to capture all important signals. Therefore several methods addressing different aspects of the data need to be applied. We have developed a framework for linear and non-linear dimension reduction methods within our visual analytics pipeline SpRay. This includes measures that assist the interpretation of the factorization result. Different visualizations of these measures can be combined with functional annotations that support the interpretation of the results. We show an application to high-resolution time series microarray data in the antibiotic-producing organism Streptomyces coelicolor as well as to microarray data measuring expression of cells with normal karyotype and cells with trisomies of human chromosomes 13 and 21

Dynamic loads analysis system (DYLOFLEX) summary. Volume 1: Engineering formulation

The DYLOFLEX computer program system expands the aeroelastic cycle from that in the FLEXSTAB computer program system to include dynamic loads analyses involving active controls. Two aerodynamic options exist within DYLOFLEX. The analyst can formulate the problem with unsteady aerodynamics calculated using the doublet lattice method or with quasi-steady aerodynamics formulated from either FLEXSTAB or doublet lattice steady state aerodynamics with unsteady effects approximated by indicial lift growth functions. The equations of motion are formulated assuming straight and level flight and small motions. Loads are calculated using the force summation technique. DYLOFLEX consists of nine standalone programs which can be linked with each other by magnetic files used to transmit the required data between programs

Efficient parallel computation on multiprocessors with optical interconnection networks

This dissertation studies optical interconnection networks, their architecture, address schemes, and computation and communication capabilities. We focus on a simple but powerful optical interconnection network model - the Linear Array with Reconfigurable pipelined Bus System (LARPBS). We extend the LARPBS model to a simplified higher dimensional LAPRBS and provide a set of basic computation operations. We then study the following two groups of parallel computation problems on both one dimensional LARPBS\u27s as well as multi-dimensional LARPBS\u27s: parallel comparison problems, including sorting, merging, and selection; Boolean matrix multiplication, transitive closure and their applications to connected component problems. We implement an optimal sorting algorithm on an n-processor LARPBS. With this optimal sorting algorithm at disposal, we study the sorting problem for higher dimensional LARPBS\u27s and obtain the following results: • An optimal basic Columnsort algorithm on a 2D LARPBS. • Two optimal two-way merge sort algorithms on a 2D LARPBS. • An optimal multi-way merge sorting algorithm on a 2D LARPBS. • An optimal generalized column sort algorithm on a 2D LARPBS. • An optimal generalized column sort algorithm on a 3D LARPBS. • An optimal 5-phase sorting algorithm on a 3D LARPBS. Results for selection problems are as follows: • A constant time maximum-finding algorithm on an LARPBS. • An optimal maximum-finding algorithm on an LARPBS. • An O((log log n)2) time parallel selection algorithm on an LARPBS. • An O(k(log log n)2) time parallel multi-selection algorithm on an LARPBS. While studying the computation and communication properties of the LARPBS model, we find Boolean matrix multiplication and its applications to the graph are another set of problem that can be solved efficiently on the LARPBS. Following is a list of results we have obtained in this area. • A constant time Boolean matrix multiplication algorithm. • An O(log n)-time transitive closure algorithm. • An O(log n)-time connected components algorithm. • An O(log n)-time strongly connected components algorithm. The results provided in this dissertation show the strong computation and communication power of optical interconnection networks