26 research outputs found
CMOS SPAD-based image sensor for single photon counting and time of flight imaging
The facility to capture the arrival of a single photon, is the fundamental limit to the detection of quantised
electromagnetic radiation. An image sensor capable of capturing a picture with this ultimate optical and
temporal precision is the pinnacle of photo-sensing. The creation of high spatial resolution, single photon
sensitive, and time-resolved image sensors in complementary metal oxide semiconductor (CMOS) technology
offers numerous benefits in a wide field of applications. These CMOS devices will be suitable to replace high
sensitivity charge-coupled device (CCD) technology (electron-multiplied or electron bombarded) with
significantly lower cost and comparable performance in low light or high speed scenarios. For example, with
temporal resolution in the order of nano and picoseconds, detailed three-dimensional (3D) pictures can be
formed by measuring the time of flight (TOF) of a light pulse. High frame rate imaging of single photons can
yield new capabilities in super-resolution microscopy. Also, the imaging of quantum effects such as the
entanglement of photons may be realised.
The goal of this research project is the development of such an image sensor by exploiting single photon
avalanche diodes (SPAD) in advanced imaging-specific 130nm front side illuminated (FSI) CMOS technology.
SPADs have three key combined advantages over other imaging technologies: single photon sensitivity,
picosecond temporal resolution and the facility to be integrated in standard CMOS technology. Analogue
techniques are employed to create an efficient and compact imager that is scalable to mega-pixel arrays. A
SPAD-based image sensor is described with 320 by 240 pixels at a pitch of 8μm and an optical efficiency or
fill-factor of 26.8%. Each pixel comprises a SPAD with a hybrid analogue counting and memory circuit that
makes novel use of a low-power charge transfer amplifier. Global shutter single photon counting images are
captured. These exhibit photon shot noise limited statistics with unprecedented low input-referred noise at an
equivalent of 0.06 electrons.
The CMOS image sensor (CIS) trends of shrinking pixels, increasing array sizes, decreasing read noise, fast
readout and oversampled image formation are projected towards the formation of binary single photon imagers
or quanta image sensors (QIS). In a binary digital image capture mode, the image sensor offers a look-ahead to
the properties and performance of future QISs with 20,000 binary frames per second readout with a bit error
rate of 1.7 x 10-3. The bit density, or cumulative binary intensity, against exposure performance of this image
sensor is in the shape of the famous Hurter and Driffield densitometry curves of photographic film.
Oversampled time-gated binary image capture is demonstrated, capturing 3D TOF images with 3.8cm
precision in a 60cm range
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Muscle activation patterns in shoulder impingement patients
Introduction: Shoulder impingement is one of the most common presentations of shoulder joint problems 1. It appears to be caused by a reduction in the sub-acromial space as the humerus abducts between 60o -120o – the 'painful arc'. Structures between the humeral head and the acromion are thus pinched causing pain and further pathology 2. Shoulder muscle activity can influence this joint space but it is unclear whether this is a cause or effect in impingement patients. This study aimed to observe muscle activation patterns in normal and impingement shoulder patients and determine if there were any significant differences.
Method: 19 adult subjects were asked to perform shoulder abduction in their symptomatic arm and non-symptomatic. 10 of these subjects (age 47.9 ± 11.2) were screened for shoulder impingement, and 9 subjects (age 38.9 ± 14.3) had no history of shoulder pathology. Surface EMG was used to collect data for 6 shoulder muscles (Upper, middle and lower trapezius, serratus anterior, infraspinatus, middle deltoids) which was then filtered and fully rectified. Subjects performed 3 smooth unilateral abduction movements at a cadence of 16 beats of a metronome set at 60bpm, and the mean of their results was recorded. T-tests were used to indicate any statistical significance in the data sets. Significance was set at P<0.05.
Results: There was a significant difference in muscle activation with serratus anterior in particular showing a very low level of activation throughout the range when compared to normal shoulder activation patterns (<30%). Middle deltoid recruitment was significantly reduced between 60-90o in the impingement group (30:58%).Trends were noted in other muscles with upper trapezius and infraspinatus activating more rapidly and erratically (63:25%; 60:27% respectively), and lower trapezius with less recruitment (13:30%) in the patient group, although these did not quite reach significance.
Conclusion: There appears to be some interesting alterations in muscle recruitment patterns in impingement shoulder patients when compared against their own unaffected shoulders and the control group. In particular changes in scapula control (serratus anterior and trapezius) and lateral rotation (infraspinatus), which have direct influence on the sub-acromial space, should be noted. It is still not clear whether these alterations are causative or reactionary, but this finding gives a clear indication to the importance of addressing muscle reeducation as part of a rehabilitation programme in shoulder impingement patients