5,924 research outputs found
E-infrastructures fostering multi-centre collaborative research into the intensive care management of patients with brain injury
Clinical research is becoming ever more collaborative with multi-centre trials now a common practice. With this in mind, never has it been more important to have secure access to data and, in so doing, tackle the challenges of inter-organisational data access and usage. This is especially the case for research conducted within the brain injury domain due to the complicated multi-trauma nature of the disease with its associated complex collation of time-series data of varying resolution and quality. It is now widely accepted that advances in treatment within this group of patients will only be delivered if the technical infrastructures underpinning the collection and validation of multi-centre research data for clinical trials is improved. In recognition of this need, IT-based multi-centre e-Infrastructures such as the Brain Monitoring with Information Technology group (BrainIT - www.brainit.org) and Cooperative Study on Brain Injury Depolarisations (COSBID - www.cosbid.de) have been formed. A serious impediment to the effective implementation of these networks is access to the know-how and experience needed to install, deploy and manage security-oriented middleware systems that provide secure access to distributed hospital based datasets and especially the linkage of these data sets across sites. The recently funded EU framework VII ICT project Advanced Arterial Hypotension Adverse Event prediction through a Novel Bayesian Neural Network (AVERT-IT) is focused upon tackling these challenges. This chapter describes the problems inherent to data collection within the brain injury medical domain, the current IT-based solutions designed to address these problems and how they perform in practice. We outline how the authors have collaborated towards developing Grid solutions to address the major technical issues. Towards this end we describe a prototype solution which ultimately formed the basis for the AVERT-IT project. We describe the design of the underlying Grid infrastructure for AVERT-IT and how it will be used to produce novel approaches to data collection, data validation and clinical trial design is also presented
Grid Databases for Shared Image Analysis in the MammoGrid Project
The MammoGrid project aims to prove that Grid infrastructures can be used for
collaborative clinical analysis of database-resident but geographically
distributed medical images. This requires: a) the provision of a
clinician-facing front-end workstation and b) the ability to service real-world
clinician queries across a distributed and federated database. The MammoGrid
project will prove the viability of the Grid by harnessing its power to enable
radiologists from geographically dispersed hospitals to share standardized
mammograms, to compare diagnoses (with and without computer aided detection of
tumours) and to perform sophisticated epidemiological studies across national
boundaries. This paper outlines the approach taken in MammoGrid to seamlessly
connect radiologist workstations across a Grid using an "information
infrastructure" and a DICOM-compliant object model residing in multiple
distributed data stores in Italy and the UKComment: 10 pages, 5 figure
Identity in research infrastructure and scientific communication: Report from the 1st IRISC workshop, Helsinki Sep 12-13, 2011
Motivation for the IRISC workshop came from the observation that identity and digital identification are increasingly important factors in modern scientific research, especially with the now near-ubiquitous use of the Internet as a global medium for dissemination and debate of scientific knowledge and data, and as a platform for scientific collaborations and large-scale e-science activities.

The 1 1/2 day IRISC2011 workshop sought to explore a series of interrelated topics under two main themes: i) unambiguously identifying authors/creators & attributing their scholarly works, and ii) individual identification and access management in the context of identity federations. Specific aims of the workshop included:

• Raising overall awareness of key technical and non-technical challenges, opportunities and developments.
• Facilitating a dialogue, cross-pollination of ideas, collaboration and coordination between diverse – and largely unconnected – communities.
• Identifying & discussing existing/emerging technologies, best practices and requirements for researcher identification.

This report provides background information on key identification-related concepts & projects, describes workshop proceedings and summarizes key workshop findings
A Taxonomy of Data Grids for Distributed Data Sharing, Management and Processing
Data Grids have been adopted as the platform for scientific communities that
need to share, access, transport, process and manage large data collections
distributed worldwide. They combine high-end computing technologies with
high-performance networking and wide-area storage management techniques. In
this paper, we discuss the key concepts behind Data Grids and compare them with
other data sharing and distribution paradigms such as content delivery
networks, peer-to-peer networks and distributed databases. We then provide
comprehensive taxonomies that cover various aspects of architecture, data
transportation, data replication and resource allocation and scheduling.
Finally, we map the proposed taxonomy to various Data Grid systems not only to
validate the taxonomy but also to identify areas for future exploration.
Through this taxonomy, we aim to categorise existing systems to better
understand their goals and their methodology. This would help evaluate their
applicability for solving similar problems. This taxonomy also provides a "gap
analysis" of this area through which researchers can potentially identify new
issues for investigation. Finally, we hope that the proposed taxonomy and
mapping also helps to provide an easy way for new practitioners to understand
this complex area of research.Comment: 46 pages, 16 figures, Technical Repor
Grids and the Virtual Observatory
We consider several projects from astronomy that benefit from the Grid paradigm and
associated technology, many of which involve either massive datasets or the federation
of multiple datasets. We cover image computation (mosaicking, multi-wavelength
images, and synoptic surveys); database computation (representation through XML,
data mining, and visualization); and semantic interoperability (publishing, ontologies,
directories, and service descriptions)
From access and integration to mining of secure genomic data sets across the grid
The UK Department of Trade and Industry (DTI) funded BRIDGES project (Biomedical Research Informatics Delivered by Grid Enabled Services) has developed a Grid infrastructure to support cardiovascular research. This includes the provision of a compute Grid and a data Grid infrastructure with security at its heart. In this paper we focus on the BRIDGES data Grid. A primary aim of the BRIDGES data Grid is to help control the complexity in access to and integration of a myriad of genomic data sets through simple Grid based tools. We outline these tools, how they are delivered to the end user scientists. We also describe how these tools are to be extended in the BBSRC funded Grid Enabled Microarray Expression Profile Search (GEMEPS) to support a richer vocabulary of search capabilities to support mining of microarray data sets. As with BRIDGES, fine grain Grid security underpins GEMEPS
Computer-based library or computer-based learning?
Traditionally, libraries have played the role of repository of published information resources and, more recently,
gateway to online subscription databases. The library online catalog and digital library interface serve an
intermediary function to help users locate information resources available through the library. With competition from Web search engines and Web portals of various kinds available for free, the library has to step up to play a more active role as guide and coach to help users make use of information resources for learning or to accomplish particular tasks. It is no longer sufficient for computer-based library systems to provide just search and access functions. They must provide the functionality and environment to support learning and become computer-based learning systems. This paper examines the kind of learning support that can be incorporated in library online catalogs and digital libraries, including 1) enhanced support for information browsing and synthesis through linking by shared meta-data, references and concepts; 2) visualization of related information; 3) adoption of Library 2.0 and social technologies; 4) adoption of Library 3.0 technologies including intelligent processing and text mining
SciTokens: Capability-Based Secure Access to Remote Scientific Data
The management of security credentials (e.g., passwords, secret keys) for
computational science workflows is a burden for scientists and information
security officers. Problems with credentials (e.g., expiration, privilege
mismatch) cause workflows to fail to fetch needed input data or store valuable
scientific results, distracting scientists from their research by requiring
them to diagnose the problems, re-run their computations, and wait longer for
their results. In this paper, we introduce SciTokens, open source software to
help scientists manage their security credentials more reliably and securely.
We describe the SciTokens system architecture, design, and implementation
addressing use cases from the Laser Interferometer Gravitational-Wave
Observatory (LIGO) Scientific Collaboration and the Large Synoptic Survey
Telescope (LSST) projects. We also present our integration with widely-used
software that supports distributed scientific computing, including HTCondor,
CVMFS, and XrootD. SciTokens uses IETF-standard OAuth tokens for
capability-based secure access to remote scientific data. The access tokens
convey the specific authorizations needed by the workflows, rather than
general-purpose authentication impersonation credentials, to address the risks
of scientific workflows running on distributed infrastructure including NSF
resources (e.g., LIGO Data Grid, Open Science Grid, XSEDE) and public clouds
(e.g., Amazon Web Services, Google Cloud, Microsoft Azure). By improving the
interoperability and security of scientific workflows, SciTokens 1) enables use
of distributed computing for scientific domains that require greater data
protection and 2) enables use of more widely distributed computing resources by
reducing the risk of credential abuse on remote systems.Comment: 8 pages, 6 figures, PEARC '18: Practice and Experience in Advanced
Research Computing, July 22--26, 2018, Pittsburgh, PA, US
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