53,701 research outputs found
Construction of embedded fMRI resting state functional connectivity networks using manifold learning
We construct embedded functional connectivity networks (FCN) from benchmark
resting-state functional magnetic resonance imaging (rsfMRI) data acquired from
patients with schizophrenia and healthy controls based on linear and nonlinear
manifold learning algorithms, namely, Multidimensional Scaling (MDS), Isometric
Feature Mapping (ISOMAP) and Diffusion Maps. Furthermore, based on key global
graph-theoretical properties of the embedded FCN, we compare their
classification potential using machine learning techniques. We also assess the
performance of two metrics that are widely used for the construction of FCN
from fMRI, namely the Euclidean distance and the lagged cross-correlation
metric. We show that the FCN constructed with Diffusion Maps and the lagged
cross-correlation metric outperform the other combinations
Region-Referenced Spectral Power Dynamics of EEG Signals: A Hierarchical Modeling Approach
Functional brain imaging through electroencephalography (EEG) relies upon the
analysis and interpretation of high-dimensional, spatially organized time
series. We propose to represent time-localized frequency domain
characterizations of EEG data as region-referenced functional data. This
representation is coupled with a hierarchical modeling approach to multivariate
functional observations. Within this familiar setting, we discuss how several
prior models relate to structural assumptions about multivariate covariance
operators. An overarching modeling framework, based on infinite factorial
decompositions, is finally proposed to balance flexibility and efficiency in
estimation. The motivating application stems from a study of implicit auditory
learning, in which typically developing (TD) children, and children with autism
spectrum disorder (ASD) were exposed to a continuous speech stream. Using the
proposed model, we examine differential band power dynamics as brain function
is interrogated throughout the duration of a computer-controlled experiment.
Our work offers a novel look at previous findings in psychiatry, and provides
further insights into the understanding of ASD. Our approach to inference is
fully Bayesian and implemented in a highly optimized Rcpp package
Diffusion map for clustering fMRI spatial maps extracted by independent component analysis
Functional magnetic resonance imaging (fMRI) produces data about activity
inside the brain, from which spatial maps can be extracted by independent
component analysis (ICA). In datasets, there are n spatial maps that contain p
voxels. The number of voxels is very high compared to the number of analyzed
spatial maps. Clustering of the spatial maps is usually based on correlation
matrices. This usually works well, although such a similarity matrix inherently
can explain only a certain amount of the total variance contained in the
high-dimensional data where n is relatively small but p is large. For
high-dimensional space, it is reasonable to perform dimensionality reduction
before clustering. In this research, we used the recently developed diffusion
map for dimensionality reduction in conjunction with spectral clustering. This
research revealed that the diffusion map based clustering worked as well as the
more traditional methods, and produced more compact clusters when needed.Comment: 6 pages. 8 figures. Copyright (c) 2013 IEEE. Published at 2013 IEEE
International Workshop on Machine Learning for Signal Processin
- …