Brain White Matter Correlates of Creativity in Schizophrenia: A Diffusion Tensor Imaging Study

The relationship between creativity and psychopathology has been a controversial research topic for decades. Specifically, it has been shown that people with schizophrenia have an impairment in creative performance. However, little is known about the brain correlates underlying this impairment. Therefore, the aim of this study was to analyze whole brain white matter (WM) correlates of several creativity dimensions in people with schizophrenia. Fifty-five patients with schizophrenia underwent diffusion-weighted imaging on a 3T magnetic resonance imaging machine as well as a clinical and a creativity assessment, including verbal and figural creativity measures. Tract-based spatial statistic, implemented in FMRIB Software Library (FSL), was used to assess whole brain WM correlates with different creativity dimensions, controlling for sex, age, premorbid IQ, and medication. Mean fractional anisotropy (FA) in frontal, temporal, subcortical, brain stem, and interhemispheric regions correlated positively with figural originality. The most significant clusters included the right corticospinal tract (cerebral peduncle part) and the right body of the corpus callosum. Verbal creativity did not show any significant correlation. As a whole, these findings suggest that widespread WM integrity is involved in creative performance of patients with schizophrenia. Many of these areas have also been related to creativity in healthy people. In addition, some of these regions have shown to be particularly impaired in schizophrenia, suggesting that these WM alterations could be underlying the worse creative performance found in this pathology.This study has been supported by the Spanish Ministry of Economy and Competitiveness (PI16/01022) and the Department of Education and Science of the Basque Government (Team A) (IT946-16). AS was supported by a fellowship from the Fundacion Tatiana Perez de Guzman el Bueno. AG-G was supported by a fellowship from the Education, Language, Politics and Culture Department of the Basque Government (PRE_2015_1_0444). The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript

Divergent thinking abilities in frontotemporal dementia: A mini-review

A large number of studies, including single case and case series studies, have shown that patients with different types of frontotemporal dementia (FTD) are characterized by the emergence of artistic abilities. This led to the hypothesis of enhanced creative thinking skills as a function of these pathological conditions. However, in the last years, it has been argued that these brain pathologies lead only to an augmented \u201cdrive to produce\u201d rather than to the emergence of creativity. Moreover, only a few studies analyzed specific creative skills, such as divergent thinking (DT), by standardized tests. This Mini-Review aimed to examine the extent to which DT abilities are preserved in patients affected by FTD. Results showed that DT abilities (both verbal and figural) are altered in different ways according to the specific anatomical and functional changes associated with the diverse forms of FTD. On the one hand, patients affected by the behavioral form of FTD can produce many ideas because of unimpaired access to memory stores (i.e., episodic and semantic), but are not able to recombine flexibly the information to produce original ideas because of damages in the pre-frontal cortex. On the other hand, patients affected by the semantic variant are impaired also in terms of fluency because of the degradation of their semantic memory store. Potential implications, limitations, and future research directions are discussed

Acute Exercise and Creativity: Embodied Cognition Approaches

This dissertation manuscript is the culmination of three years of research examining several unique, exercise-induced mechanisms underlying creativity. This collection of work addresses historical and current empirical concepts of creativity in a narrative review, providing recommendations for future research. Several reviews follow this introduction, highlighting the proposed effects of exercise on creativity, putative mechanisms for creativity, and the effects of exercise and embodied manipulations on creative behavior. Multiple experiments utilizing moderate-intensity exercise as a theoretical stimulus for higher-order cognitions were conducted to investigate associations between exercise and creativity, which lead to the final dissertation experiment. The dissertation experiment was the first to provide statistically significant evidence for acute, moderate-intensity treadmill exercise coupled with anagram problem-solving to prime subsequent RAT completion compared to a non-exercise, priming only condition. We emphasize that the additive effects of exercise plus priming may be a viable strategy for enhancing verbal convergent creativity. Future research is warranted to explore a variety of priming effects on the relationship between exercise, embodied interventions, and creativityThis dissertation manuscript is the culmination of three years of research examining several unique, exercise-induced mechanisms underlying creativity. This collection of work addresses historical and current empirical concepts of creativity in a narrative review, providing recommendations for future research. Several reviews follow this introduction, highlighting the proposed effects of exercise on creativity, putative mechanisms for creativity, and the effects of exercise and embodied manipulations on creative behavior. Multiple experiments utilizing moderate-intensity exercise as a theoretical stimulus for higher-order cognitions were conducted to investigate associations between exercise and creativity, which lead to the final dissertation experiment. The dissertation experiment was the first to provide statistically significant evidence for acute, moderate-intensity treadmill exercise coupled with anagram problem-solving to prime subsequent RAT completion compared to a non-exercise, priming only condition. We emphasize that the additive effects of exercise plus priming may be a viable strategy for enhancing verbal convergent creativity. Future research is warranted to explore a variety of priming effects on the relationship between exercise, embodied interventions, and creativit

Synchronised neural signature of creative mental imagery in reality and augmented reality

Creativity, transforming imaginative thinking into reality, is a mental imagery simulation in essence. It can be incorporeal, concerns sophisticated and/or substantial thinking, and involves objects. In the present study, a mental imagery task consisting of creating a scene using familiar (FA) or abstract (AB) physical or virtual objects in real (RMI) and augmented reality (VMI) environments, and an execution task involving effectively creating a scene in augmented reality (VE), were utilised. The beta and gamma neural oscillations of healthy participants were recorded via a 32 channel wireless 10/20 international EGG system. In real and augmented environments and for both the mental imagery and execution tasks, the participants displayed a similar cortico-cortical neural signature essentially based on synchronous vs asynchronous beta and gamma oscillatory activities between anterior (i.e. frontal) and posterior (i.e. parietal, occipito-parietal and occipito-temporal) areas bilaterally. The findings revealed a transient synchronised neural architecture that appears to be consistent with the hypothesis according to which, creativity, because of its inherent complexity, cannot be confined to a single brain area but engages various interconnected networks

Beyond neurons and spikes: cognon, the hierarchical dynamical unit of thought

From the dynamical point of view, most cognitive phenomena are hierarchical, transient and sequential. Such cognitive spatio-temporal processes can be represented by a set of sequential metastable dynamical states together with their associated transitions: The state is quasi-stationary close to one metastable state before a rapid transition to another state. Hence, we postulate that metastable states are the central players in cognitive information processing. Based on the analogy of quasiparticles as elementary units in physics, we introduce here the quantum of cognitive information dynamics, which we term ‘‘cognon’’. A cognon, or dynamical unit of thought, is represented by a robust finite chain of metastable neural states. Cognons can be organized at multiple hierarchical levels and coordinate complex cognitive information representations. Since a cognon is an abstract conceptualization, we link this abstraction to brain sequential dynamics that can be measured using common modalities and argue that cognons and brain rhythms form binding spatiotemporal complexes to keep simultaneous dynamical information which relate the ‘what’, ‘where’ and ‘when’This work was supported by Grants PGC2018- 095895-B-I00 and PID2021-122347NB-I00 funded by MCIN/AEI/ 10.13039/501100011033 and ERDF –‘‘A way of making Europe’

Design spaces and EEG frequency band power in constrained and open design

Design space is a common abstraction used in the investigation of design cognition. Characteristic properties of design spaces and how they change are underexplored. Design spaces can vary with the design task and its constraints, which are assumed to result in differences in neurocognitive processes. We review general cognition, creative cognition and design neurocognition EEG studies. We analyzed the brain activity of 32 professional mechanical engineers and industrial designers while performing constrained and open design tasks. The neurophysiological activations during reading the task, earliest reaction, and open externalization stages of constrained and open design are compared based on EEG frequency band power. Significant differences between constrained and open design for the beta bands were found in the earliest reaction stage. Significant differences between constrained and open design for alpha 2 and the beta bands were found in the open externalization stage. We discuss the results and relate the higher brain activity and significant differences in open design to cognitive functions of interest to design cognition. We show that EEG brain activation is sensitive to the level of constraints in designing, in particular alpha 2 and beta bands can act as proxies of the change and expansion of design spaces

The Dynamics of Creative Ideation: Introducing a New Assessment Paradigm

Despite six decades of creative cognition research, measures of creative ideation have heavily relied on divergent thinking tasks, which still suffer from conceptual, design, and psychometric shortcomings. These shortcomings have greatly impeded the accurate study of creative ideation, its dynamics, development, and integration as part of a comprehensive psychological assessment. After a brief overview of the historical and current anchoring of creative ideation measurement, overlooked challenges in its most common operationalization (i.e., divergent thinking tasks framework) are discussed. They include (1) the reliance on a single stimulus as a starting point of the creative ideation process (stimulus-dependency), (2) the analysis of response quality based on a varying number of observations across test-takers (fluency-dependency), and (3) the production of “static” cumulative performance indicators. Inspired from an emerging line of work from the field of cognitive neuroscience of creativity, this paper introduces a new assessment framework referred to as “Multi-Trial Creative Ideation” (MTCI). This framework shifts the current measurement paradigm by (1) offering a variety of stimuli presented in a well-defined set of ideation “trials,” (2) reinterprets the concept of ideational fluency using a time-analysis of idea generation, and (3) captures individual dynamics in the ideation process (e.g., modeling the effort-time required to reach a response of maximal uncommonness) while controlling for stimulus-specific sources of variation. Advantages of the MTCI framework over the classic divergent thinking paradigm are discussed in light of current directions in the field of creativity research

A Meta-Analysis of Functional Magnetic Resonance Imaging Studies of Divergent thinking using Activation Likelihood Estimation

There are conflicting findings regarding brain regions and networks underpinning creativity, with divergent thinking tasks commonly used to study this. A handful of meta‐analyses have attempted to synthesise findings on neural mechanisms of divergent thinking. With the rapid proliferation of research and recent developments in fMRI meta‐analysis approaches, it is timely to reassess the regions activated during divergent thinking creativity tasks. Of particular interest is examining the evidence regarding large‐scale brain networks proposed to be key in divergent thinking and extending this work to consider the role of the semantic control network. Studies utilising fMRI with healthy participants completing divergent thinking tasks were systematically identified, with 20 studies meeting the criteria. Activation Likelihood Estimation was then used to integrate the neuroimaging results across studies. This revealed four clusters: the left inferior parietal lobe; the left inferior frontal and precentral gyrus; the superior and medial frontal gyrus and the right cerebellum. These regions are key in the semantic network, important for flexible retrieval of stored knowledge, highlighting the role of this network in divergent thinking.A meta‐analysis of fMRI studies into divergent thinking, with a comparison to default mode, multiple demand and semantic control networks. This found four clusters; the left inferior parietal lobe; the left inferior frontal and precentral gyrus; the superior and medial frontal gyrus and the right cerebellum. The largest overlap is with the semantic control network, highlighting the role of this network in divergent thinking

A mixed methods analysis of how executive control processes contribute, positively and negatively, to children’s creativity

Creativity is one of humanity’s most important assets. Training it in children is seen as a crucial component of ‘21stcentury skills. ’Executive control (EC)comprises a suite of processes shown to improve life chances, from educational attainment to greater health and wealth. This thesis explores the relationship between these two key capabilities, specifically addressing the question of whether training children in EC reduces their creativity. The first study was a cross-sectional, quantitative investigation of the development of creativity and EC in 45children aged 5-11 years. Findings showed that while EC measures improved, most creativity measures did not, surprising given expected developmental trajectories for complex cognition. The second, qualitative study involved a subset of the same children and used stimulated recall interviews to elicit descriptions of their mental processes while completing a creativity activity at home. Their verbal reports suggested wide variation in how they deployed EC in their creativity, with differences in the levels of spontaneous(EC independent)and control (EC dependent) processes and in the flexibility to modulate between them. Triangulation of findings showed that greater spontaneity tended to be positively associated with creativity, while extremes of control were negatively associated-the first suggestion that better EC might have negative side effects. The second set of studies moved from correlation to study causation. A large nested school-based intervention involving 156 children, was designed to train and improve EC in children aged 8-10. Children were randomized by class to the EC group or a matched, active control group and were tested on EC and creativity measures before and after training. The intervention brought about EC improvements in both EC training and control classes, with EC performance improving similarly and significantly in both. The transfer effects to creative performance, also similar across groups, were mixed; while fluency improved, originality declined. After training to improve EC, children produced more, worse ideas. The final studies investigated training effects qualitatively, with a subset of children involved in the intervention. This time, they all completed the same activity (as each other and as used in pre and post intervention assessments) to stimulate recall of their thought process while creating. Their qualitative reports formed the basis for defining creative sub types, based on differing cognitive approaches. Triangulation analysis investigated whether the qualitative assessment of the relative degree of control, spontaneity, and flexibility that children deployed in their creativity associated with their performance in quantitative tests. Were there, in short, better or worse ways of ‘doing creativity’? Flexibility emerged as a key ingredient to creative success –with more flexible children seeing greater fluency gains after training and less substantial originality losses. The discussion addresses the question of whether, in our enthusiasm to promote EC training, insufficient consideration has been given to its possible side effects, specifically in demoting original creative thinking. It broadens out to look at the relevance of the current research to education, aligning findings here with an existing conflict between performativity and creativity. Finally, suggestions are made for how to effectively teach children so that their creativity, as well as their EC, can thrive

Functional neuroimaging of visual creativity: a systematic review and meta-analysis

Introduction: The generation of creative visual imagery contributes to technological and scientific innovation, and production of visual art. The underlying cognitive and neural processes are however poorly understood. Methods: This review synthesises functional neuroimaging studies of visual creativity. Seven functional magnetic resonance imaging (fMRI) and 19 electroencephalography (EEG) studies were included, comprising 27 experiments and around 800 participants. Results: Activation likelihood estimation meta-analysis of the fMRI studies comparing visual creativity to non-rest control tasks yielded significant clusters in thalamus, left fusiform gyrus, and right middle and inferior frontal gyri. The EEG studies revealed a tendency for decreased alpha power during visual creativity compared to baseline, but comparisons of visual creativity to non-rest control tasks revealed inconsistent findings. Conclusions: The findings are consistent with suggested contributions to visual creativity of prefrontally-mediated inhibition, evaluation and working memory, as well as visual imagery processes. Findings are discussed in relation to prominent theories of the neural basis of creativity