139,344 research outputs found

    Life-cycle assessment of buildings: a Review

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    Life-Cycle Assessment (LCA) is one of various management tools for evaluating environmental concerns. This paper reviews LCA from a buildings perspective. It highlights the need for its use within the building sector, and the importance of LCA as a decision making support tool. It discusses LCA methodologies and applications within the building sector, reviewing some of the life-cycle studies applied to buildings or building materials and component combinations within the last fifteen years in Europe and the United States. It highlights the problems of a lack of an internationally comparable and agreed data inventory and assessment methodology which hinder the application of LCA within the building industry. It identifies key areas for future research as (i) the whole process of construction, (ii) the relative weighting of different environmental impacts and (iii) applications in developing countries

    Research gaps in diet and nutrition in inflammatory bowel disease. A topical review by D-ECCO Working Group (Dietitians of ECCO)

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    Although the current doctrine of IBD pathogenesis proposes an interaction between environmental factors with gut microbiota in genetically-susceptible individuals, dietary exposures have attracted recent interest and are, at least in part, likely to explain the rapid rise in disease incidence and prevalence. The D-ECCO working group along with other ECCO experts with expertise in nutrition, microbiology, physiology and medicine reviewed the evidence investigating the role of diet and nutritional therapy in the onset, perpetuation and management of IBD. A narrative topical review is presented where evidence pertinent to the topic is summarized collectively under three main thematic domains: i) the role of diet as an environmental factor in IBD aetiology; ii) the role of diet as induction and maintenance therapy in IBD; and iii) assessment of nutritional status and supportive nutritional therapy in IBD. A summary of research gaps for each of these thematic domains is proposed which is anticipated to be agenda setting for future research in the area of diet and nutrition in IBD

    Invertible Program Restructurings for Continuing Modular Maintenance

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    When one chooses a main axis of structural decompostion for a software, such as function- or data-oriented decompositions, the other axes become secondary, which can be harmful when one of these secondary axes becomes of main importance. This is called the tyranny of the dominant decomposition. In the context of modular extension, this problem is known as the Expression Problem and has found many solutions, but few solutions have been proposed in a larger context of modular maintenance. We solve the tyranny of the dominant decomposition in maintenance with invertible program transformations. We illustrate this on the typical Expression Problem example. We also report our experiments with Java and Haskell programs and discuss the open problems with our approach.Comment: 6 pages, Early Research Achievements Track; 16th European Conference on Software Maintenance and Reengineering (CSMR 2012), Szeged : Hungary (2012

    Detecting stars, galaxies, and asteroids with Gaia

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    (Abridged) Gaia aims to make a 3-dimensional map of 1,000 million stars in our Milky Way to unravel its kinematical, dynamical, and chemical structure and evolution. Gaia's on-board detection software discriminates stars from spurious objects like cosmic rays and Solar protons. For this, parametrised point-spread-function-shape criteria are used. This study aims to provide an optimum set of parameters for these filters. We developed an emulation of the on-board detection software, which has 20 free, so-called rejection parameters which govern the boundaries between stars on the one hand and sharp or extended events on the other hand. We evaluate the detection and rejection performance of the algorithm using catalogues of simulated single stars, double stars, cosmic rays, Solar protons, unresolved galaxies, and asteroids. We optimised the rejection parameters, improving - with respect to the functional baseline - the detection performance of single and double stars, while, at the same time, improving the rejection performance of cosmic rays and of Solar protons. We find that the minimum separation to resolve a close, equal-brightness double star is 0.23 arcsec in the along-scan and 0.70 arcsec in the across-scan direction, independent of the brightness of the primary. We find that, whereas the optimised rejection parameters have no significant impact on the detectability of de Vaucouleurs profiles, they do significantly improve the detection of exponential-disk profiles. We also find that the optimised rejection parameters provide detection gains for asteroids fainter than 20 mag and for fast-moving near-Earth objects fainter than 18 mag, albeit this gain comes at the expense of a modest detection-probability loss for bright, fast-moving near-Earth objects. The major side effect of the optimised parameters is that spurious ghosts in the wings of bright stars essentially pass unfiltered.Comment: Accepted for publication in A&

    Managing Madness: The ethics of identifying and treating mental illness

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    This essay analyzes different contemporary models for defining mental illness and offers a new framework that promotes the use of normative values during the clinical diagnostic process. Although ethic centric models for identifying mental illness do currently exist, these accounts are limited. Specifically, these accounts acknowledge the relationship between mental illness labels and implied responsibility in making their argument to support a normative framework, yet do not explain what capacities are necessary for an agent to have full responsibility. Recognizing this shortcoming, this paper provides an enriched model for identifying mental illness by marrying a normative conception of psychiatric dysfunction to a differential model for assigning moral responsibility. To end this paper looks at how this model may be applied in clinical practice by working through a specific case study of Alcohol Dependence Disorder. Ultimately, I conclude that a normative conception of mental illness married to an account of responsibility is a more appropriate and comprehensive model for recognizing and treating psychiatric dysfunction in clinical practice. By carefully balancing normative and pragmatic considerations, physicians can create more effective and just therapeutic regimens that are tailored to individual patients’ circumstances and needs

    Functional Neuroimaging Investigation of the Neural Mechanisms for Successful Feeling-of-Knowing Judgments

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    A feeling-of-knowing (FOK) is a sense of knowing that an item would be recognizable if seen again later, despite one’s current inability to recall that item from memory. An FOK judgment occurs after a memory search and is a prediction of future recognition. The current study aimed to: (1) determine the brain regions involved in successful (accurate) and unsuccessful (inaccurate) episodic FOKs; (2) replicate the ability of FOKs to predict recognition outcomes and recollection/know (R/K) judgments; (3) explore the different effects of familiarity and recollection on high and low FOKs; and (4) determine the effect of overlearning on FOKs and their ability to predict recognition and R/K outcomes. Nine younger adults (ages 18-26) participated in 2 experimental sessions (encoding and testing), separated by a 48-hour delay (n = 4 for fMRI data). The amount of exposure to the studied items (1 versus 3 presentations) was manipulated. Statistically significant results include (1) a repetition effect such that the words that were repeated during encoding have higher mean recall, mean FOK rating, mean recognition accuracy, and mean R/K than those words presented only once; (2) activity in the ventral lateral prefrontal cortex (PFC) for successful or accurate FOKs; (3) activity in the anterior PFC for accurate high FOKs; and (4) activity in the PFC and anterior cingulate for correctly recognized and remembered items. In future, additional participants are necessary to conduct further and more detailed analyses.Hertzog, Chris - Faculty Mentor ; Schumacher, Eric - Committee Member/Second Reade

    Acquiring and Applying Knowledge in Transnational Teams: The Roles of Cosmopolitans and Locals

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    This paper examines the roles of cosmopolitans and locals in transnational teams that work on knowledge-intensive projects. I propose that cosmopolitan and local team members can help their teams to acquire and apply knowledge more effectively, by bringing both internal and external knowledge to their teams and enabling them to more successfully transform this knowledge into improved project performance. Findings from a study of 96 project teams at an international development agency reveal that the roles of cosmopolitans and locals were complex and sometimes valuable, but cosmopolitans offered greater benefits than locals and too many of each could hurt. Implications for theory and research on international management, virtual teams, exploration and exploitation, and organizational knowledge are discussed

    Systematic innovation and the underlying principles behind TRIZ and TOC

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    Innovative developments in the design of product and manufacturing systems are often marked by simplicity, at least in retrospect, that has previously been shrouded by restrictive mental models or limited knowledge transfer. These innovative developments are often associated with the breaking of long established trade-off compromises, as in the paradigm shift associated with JIT & TQM, or the resolution of design contradictions, as in the case of the dual cyclone vacuum cleaner. The rate of change in technology and the commercial environment suggests the opportunity for innovative developments is accelerating, but what systematic support is there to guide this innovation process. This paper brings together two parallel, but independent theories on inventive problem solving; one in mechanical engineering, namely the Russian Theory of Inventive Problem Solving (TRIZ) and the other originating in manufacturing management as the Theory of Constraints (TOC). The term systematic innovation is used to describe the use of common underlying principles within these two approaches. The paper focuses on the significance of trade-off contradictions to innovation in these two fields and explores their relationship with manufacturing strategy development

    Hierarchical coexistence of universality and diversity controls robustness and multi-functionality in intermediate filament protein networks

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    Proteins constitute the elementary building blocks of a vast variety of biological materials such as cellular protein networks, spider silk or bone, where they create extremely robust, multi-functional materials by self-organization of structures over many length- and time scales, from nano to macro. Some of the structural features are commonly found in a many different tissues, that is, they are highly conserved. Examples of such universal building blocks include alpha-helices, beta-sheets or tropocollagen molecules. In contrast, other features are highly specific to tissue types, such as particular filament assemblies, beta-sheet nanocrystals in spider silk or tendon fascicles. These examples illustrate that the coexistence of universality and diversity – in the following referred to as the universality-diversity paradigm (UDP) – is an overarching feature in protein materials. This paradigm is a paradox: How can a structure be universal and diverse at the same time? In protein materials, the coexistence of universality and diversity is enabled by utilizing hierarchies, which serve as an additional dimension beyond the 3D or 4D physical space. This may be crucial to understand how their structure and properties are linked, and how these materials are capable of combining seemingly disparate properties such as strength and robustness. Here we illustrate how the UDP enables to unify universal building blocks and highly diversified patterns through formation of hierarchical structures that lead to multi-functional, robust yet highly adapted structures. We illustrate these concepts in an analysis of three types of intermediate filament proteins, including vimentin, lamin and keratin
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