Functional Brain Imaging with Multi-Objective Multi-Modal Evolutionary Optimization

Functional brain imaging is a source of spatio-temporal data mining problems. A new framework hybridizing multi-objective and multi-modal optimization is proposed to formalize these data mining problems, and addressed through Evolutionary Computation (EC). The merits of EC for spatio-temporal data mining are demonstrated as the approach facilitates the modelling of the experts' requirements, and flexibly accommodates their changing goals

Machine Learning for Fluid Mechanics

The field of fluid mechanics is rapidly advancing, driven by unprecedented volumes of data from field measurements, experiments and large-scale simulations at multiple spatiotemporal scales. Machine learning offers a wealth of techniques to extract information from data that could be translated into knowledge about the underlying fluid mechanics. Moreover, machine learning algorithms can augment domain knowledge and automate tasks related to flow control and optimization. This article presents an overview of past history, current developments, and emerging opportunities of machine learning for fluid mechanics. It outlines fundamental machine learning methodologies and discusses their uses for understanding, modeling, optimizing, and controlling fluid flows. The strengths and limitations of these methods are addressed from the perspective of scientific inquiry that considers data as an inherent part of modeling, experimentation, and simulation. Machine learning provides a powerful information processing framework that can enrich, and possibly even transform, current lines of fluid mechanics research and industrial applications.Comment: To appear in the Annual Reviews of Fluid Mechanics, 202

Multi-Class Classifier in Parkinson’s Disease Using an Evolutionary Multi-Objective Optimization Algorithm

This work was funded by the Spanish Ministry of Sciences, Innovation and Universities under Project RTI-2018-101674-B-I00 and the projects from Junta de Andalucia B-TIC-414, A-TIC-530-UGR20 and P20-00163.In this contribution, a novel methodology for multi-class classification in the field of Parkinson’s disease is proposed. The methodology is structured in two phases. In a first phase, the most relevant volumes of interest (VOI) of the brain are selected by means of an evolutionary multi-objective optimization (MOE) algorithm. Each of these VOIs are subjected to volumetric feature extraction using the Three-Dimensional Discrete Wavelet Transform (3D-DWT). When applying 3D-DWT, a high number of coefficients is obtained, requiring the use of feature selection/reduction algorithms to find the most relevant features. The method used in this contribution is based on Mutual Redundancy (MI) and Minimum Maximum Relevance (mRMR) and PCA. To optimize the VOI selection, a first group of 550 MRI was used for the 5 classes: PD, SWEDD, Prodromal, GeneCohort and Normal. Once the Pareto Front of the solutions is obtained (with varying degrees of complexity, reflected in the number of selected VOIs), these solutions are tested in a second phase. In order to analyze the SVM classifier accuracy, a test set of 367 MRI was used. The methodology obtains relevant results in multi-class classification, presenting several solutions with different levels of complexity and precision (Pareto Front solutions), reaching a result of 97% as the highest precision in the test data.Spanish Government RTI-2018-101674-B-I00Junta de Andalucia B-TIC-414 A-TIC-530-UGR20 P20-0016

The nonhuman primate neuroimaging and neuroanatomy project

Multi-modal neuroimaging projects such as the Human Connectome Project (HCP) and UK Biobank are advancing our understanding of human brain architecture, function, connectivity, and their variability across individuals using high-quality non-invasive data from many subjects. Such efforts depend upon the accuracy of non-invasive brain imaging measures. However, ‘ground truth’ validation of connectivity using invasive tracers is not feasible in humans. Studies using nonhuman primates (NHPs) enable comparisons between invasive and non-invasive measures, including exploration of how “functional connectivity” from fMRI and “tractographic connectivity” from diffusion MRI compare with long-distance connections measured using tract tracing. Our NonHuman Primate Neuroimaging & Neuroanatomy Project (NHP_NNP) is an international effort (6 laboratories in 5 countries) to: (i) acquire and analyze high-quality multi-modal brain imaging data of macaque and marmoset monkeys using protocols and methods adapted from the HCP; (ii) acquire quantitative invasive tract-tracing data for cortical and subcortical projections to cortical areas; and (iii) map the distributions of different brain cell types with immunocytochemical stains to better define brain areal boundaries. We are acquiring high-resolution structural, functional, and diffusion MRI data together with behavioral measures from over 100 individual macaques and marmosets in order to generate non-invasive measures of brain architecture such as myelin and cortical thickness maps, as well as functional and diffusion tractography-based connectomes. We are using classical and next-generation anatomical tracers to generate quantitative connectivity maps based on brain-wide counting of labeled cortical and subcortical neurons, providing ground truth measures of connectivity. Advanced statistical modeling techniques address the consistency of both kinds of data across individuals, allowing comparison of tracer-based and non-invasive MRI-based connectivity measures. We aim to develop improved cortical and subcortical areal atlases by combining histological and imaging methods. Finally, we are collecting genetic and sociality-associated behavioral data in all animals in an effort to understand how genetic variation shapes the connectome and behavior

A Comparison of Archiving Strategies for Characterization of Nearly Optimal Solutions under Multi-Objective Optimization

[EN] In a multi-objective optimization problem, in addition to optimal solutions, multimodal and/or nearly optimal alternatives can also provide additional useful information for the decision maker. However, obtaining all nearly optimal solutions entails an excessive number of alternatives. Therefore, to consider the nearly optimal solutions, it is convenient to obtain a reduced set, putting the focus on the potentially useful alternatives. These solutions are the alternatives that are close to the optimal solutions in objective space, but which differ significantly in the decision space. To characterize this set, it is essential to simultaneously analyze the decision and objective spaces. One of the crucial points in an evolutionary multi-objective optimization algorithm is the archiving strategy. This is in charge of keeping the solution set, called the archive, updated during the optimization process. The motivation of this work is to analyze the three existing archiving strategies proposed in the literature (ArchiveUpdateP(Q,epsilon)D(xy), Archive_nevMOGA, and targetSelect) that aim to characterize the potentially useful solutions. The archivers are evaluated on two benchmarks and in a real engineering example. The contribution clearly shows the main differences between the three archivers. This analysis is useful for the design of evolutionary algorithms that consider nearly optimal solutions.This work was supported in part by the Ministerio de Ciencia, Innovacion y Universidades (Spain) (grant number RTI2018-096904-B-I00), by the Generalitat Valenciana regional government through project AICO/2019/055 and by the Universitat Politecnica de Valencia (grant number SP20200109).Pajares-Ferrando, A.; Blasco, X.; Herrero Durá, JM.; Martínez Iranzo, MA. (2021). A Comparison of Archiving Strategies for Characterization of Nearly Optimal Solutions under Multi-Objective Optimization. Mathematics. 9(9):1-28. https://doi.org/10.3390/math9090999S1289