Protein folding and the robustness of cells

The intricate intracellular infrastructure of all known life forms is based on proteins. The folded shape of a protein determines both the protein’s function and the set of molecules it will bind to. This tight coupling between a protein’s function and its interconnections in the molecular interaction network has consequences for the molecular course of evolution. It is also counter to human engineering approaches. Here we report on a simulation study investigating the impact of random errors in an abstract metabolic network of 500 enzymes. Tight coupling between function and interconnectivity of nodes is compared to the case where these two properties are independent. Our results show that the model system under consideration is more robust if function and interconnection are intertwined. These findings are discussed in the context of nanosystems engineering

Semibiotic Persistence

From observation, we find four different strategies to successfully enable structures to persist over extended periods of time. If functionally relevant features are very large compared to the changes that can be effectuated by entropy, the functional structure itself has a high enough probability to erode only slowly over time. If the functionally relevant features are protected from environmental influence by sacrificial layers that absorb the impinging of the environment,deterioration can be avoided or slowed. Loss of functionality can be delayed, even for complex systems, by keeping alternate options for all required components available. Biological systems also apply information processing to actively counter the impact of entropy. The latter strategy increases the overall persistence of living systems and enables them to maintain a highly complex functional organisation during their lifetime and over generations. In contrast to the other strategies, information processing has only low material overhead. While at present engineered technology is far from achieving the self-repair of evolved systems, the semibiotic combination of biological components with conventionally engineered systems may open a path to long-term persistence of functional devices in harsh environments. We review nature’s strategies for persistence, and consider early steps taken in the laboratory to import such capabilities into engineered architectures.<br/

Forgetting To Remember : Remembering To Forget: a space for reconciliation and transformation in post-apartheid South Africa

This dissertation discusses the origin, development and implementation of the design project - a reconciliation memorial in the Schotschekloof quarry in Cape Town. The project aims to illuminate the opportunity for architecture to engender reconciliation, and therefore contribute, however subtly, towards the transformation of a society. It is applied to the South African post-Apartheid context through the lens of the Truth and Reconciliation Commission, but deals with universal themes of memory, loss and forgiveness. The project critically explores reconciliation resulting from the interplay of memory and forgetting within the spatial confines of the memorial. It explores the functional aspects of both processes expanding on the traditional definition of commemorative space in art and architecture

From prescriptive programming of solid-state devices to orchestrated self-organisation of informed matter

Achieving real-time response to complex, ambiguous, high-bandwidth data is impractical with conventional programming. Only the narrow class of compressible input-output maps can be specified with feasibly sized programs. Present computing concepts enforce formalisms that are arbitrary from the perspective of the physics underlying their implementation. Efficient physical realizations are embarrassed by the need to implement the rigidly specified instructions requisite for programmable systems. The conventional paradigm of erecting strong constraints and potential barriers that narrowly prescribe structure and precisely control system state needs to be complemented with a new approach that relinquishes detailed control and reckons with autonomous building blocks. Brittle prescriptive control will need to be replaced with resilient self-organisation to approach the robustness and efficiency afforded by natural systems. Structure-function self-consistency will be key to the spontaneous generation of functional architectures that can harness novel molecular and nano materials in an effective way for increased computational power

Strategy transformation and change : changing paradigms in Australian Catholic health and aged care

When I was younger I always conceived of a room where all these (strategic) concepts were worked out for the whole, company. Later I didn't find any such room .... The strategy (of the company) may not even exist in the mind of one man. I certainly don't know where it is written down. It is simply transmitted in the series of decisions made (Quinn 1978: 7). How do organisations in the Australian Catholic Health and Aged Care sector transform shared strategic thinking into formulated strategy? This research has investigated strategy formation, which can be defined as the process whereby the insights and thoughts of the key players in Catholic health and aged care are converted into formulated strategies. Specifically, the research analysed a major strategic amalgamation of the health and aged care operations of the Catholic Church in Australia, identified as Integration 2000. The concept of social constructs of meaning for the key actors is the fundamental perspective of this research. This required a constructivist ontology. The epistemology is interpretivist, and set out to provide a description of perceptions of the key actors as they engage in the formation of strategy. Defenders of interpretivism argued that the human sciences aim to understand human action (Schwandt, 2000:191). A qualitative methodology has been used to provide a plausible interpretation of the conversion process commonly referred to as strategy formation.A purposive sample was obtained. The data collection methods included qualitative interviews, attendance as an observer at two of the three day National Conferences of Catholic Health Australia and document analysis (see Chapter Three).A key focus of the research was the identification of planning models used to set the strategic context of organisations in Catholic health. The research showed that the prescriptive design and planning models were not used to plan broad strategy, but to implement strategies already formed by an emergent/learning process which, in Mintzberg et al's (1998) terms, would fit the learning, cultural and environmental schools of thought. Pinpointing a strategy school may not be a particularly fruitful exercise in this particular arena. It assumes that the distinctive act of deciding the future shape and the strategic management context of organisations charged with fulfilling a sacred mission can be classified into one school or another. The research also explored the perceptions of the Integration 2000 process, including the compatibility between the espoused philosophies and values of Catholic health and aged care and the behaviours evidenced during the Integration 2000 process. A diagnostic model was used to perform this evaluation. Rather than uncovering major discrepancies, this revealed some differences and some potential challenges.The espoused philosophies and values of Catholic health and aged care are those of compassion, collaboration, sense of community and, of course, financial viability. Pre-Integration 2000, particularly in health care, theories of organising and practices reflected values of independence and competitiveness, both between and even within religious orders. The findings from post-Integration 2000 suggested that theories of organising and practices were becoming more aligned with the original and continuing values, at the same time as responsibility for sustaining these values was being handed over from religious to lay trusteeship. There are still some outstanding issues before the Integration 2000 process achieves its objectives. The progress to date in bringing together so many components of such a disparate sector attests to the strength of the underlying value systems of Catholic health and aged care

Internet of Things. Information Processing in an Increasingly Connected World

This open access book constitutes the refereed post-conference proceedings of the First IFIP International Cross-Domain Conference on Internet of Things, IFIPIoT 2018, held at the 24th IFIP World Computer Congress, WCC 2018, in Poznan, Poland, in September 2018. The 12 full papers presented were carefully reviewed and selected from 24 submissions. Also included in this volume are 4 WCC 2018 plenary contributions, an invited talk and a position paper from the IFIP domain committee on IoT. The papers cover a wide range of topics from a technology to a business perspective and include among others hardware, software and management aspects, process innovation, privacy, power consumption, architecture, applications

Exploring the landscapes of "computing": digital, neuromorphic, unconventional -- and beyond

The acceleration race of digital computing technologies seems to be steering toward impasses -- technological, economical and environmental -- a condition that has spurred research efforts in alternative, "neuromorphic" (brain-like) computing technologies. Furthermore, since decades the idea of exploiting nonlinear physical phenomena "directly" for non-digital computing has been explored under names like "unconventional computing", "natural computing", "physical computing", or "in-materio computing". This has been taking place in niches which are small compared to other sectors of computer science. In this paper I stake out the grounds of how a general concept of "computing" can be developed which comprises digital, neuromorphic, unconventional and possible future "computing" paradigms. The main contribution of this paper is a wide-scope survey of existing formal conceptualizations of "computing". The survey inspects approaches rooted in three different kinds of background mathematics: discrete-symbolic formalisms, probabilistic modeling, and dynamical-systems oriented views. It turns out that different choices of background mathematics lead to decisively different understandings of what "computing" is. Across all of this diversity, a unifying coordinate system for theorizing about "computing" can be distilled. Within these coordinates I locate anchor points for a foundational formal theory of a future computing-engineering discipline that includes, but will reach beyond, digital and neuromorphic computing.Comment: An extended and carefully revised version of this manuscript has now (March 2021) been published as "Toward a generalized theory comprising digital, neuromorphic, and unconventional computing" in the new open-access journal Neuromorphic Computing and Engineerin