PVR: Patch-to-Volume Reconstruction for Large Area Motion Correction of Fetal MRI

In this paper we present a novel method for the correction of motion artifacts that are present in fetal Magnetic Resonance Imaging (MRI) scans of the whole uterus. Contrary to current slice-to-volume registration (SVR) methods, requiring an inflexible anatomical enclosure of a single investigated organ, the proposed patch-to-volume reconstruction (PVR) approach is able to reconstruct a large field of view of non-rigidly deforming structures. It relaxes rigid motion assumptions by introducing a specific amount of redundant information that is exploited with parallelized patch-wise optimization, super-resolution, and automatic outlier rejection. We further describe and provide an efficient parallel implementation of PVR allowing its execution within reasonable time on commercially available graphics processing units (GPU), enabling its use in the clinical practice. We evaluate PVR's computational overhead compared to standard methods and observe improved reconstruction accuracy in presence of affine motion artifacts of approximately 30% compared to conventional SVR in synthetic experiments. Furthermore, we have evaluated our method qualitatively and quantitatively on real fetal MRI data subject to maternal breathing and sudden fetal movements. We evaluate peak-signal-to-noise ratio (PSNR), structural similarity index (SSIM), and cross correlation (CC) with respect to the originally acquired data and provide a method for visual inspection of reconstruction uncertainty. With these experiments we demonstrate successful application of PVR motion compensation to the whole uterus, the human fetus, and the human placenta.Comment: 10 pages, 13 figures, submitted to IEEE Transactions on Medical Imaging. v2: wadded funders acknowledgements to preprin

A Fetal Brain magnetic resonance Acquisition Numerical phantom (FaBiAN)

Accurate characterization of in utero human brain maturation is critical as it involves complex and interconnected structural and functional processes that may influence health later in life. Magnetic resonance imaging is a powerful tool to investigate equivocal neurological patterns during fetal development. However, the number of acquisitions of satisfactory quality available in this cohort of sensitive subjects remains scarce, thus hindering the validation of advanced image processing techniques. Numerical phantoms can mitigate these limitations by providing a controlled environment with a known ground truth. In this work, we present FaBiAN, an open-source Fetal Brain magnetic resonance Acquisition Numerical phantom that simulates clinical T2-weighted fast spin echo sequences of the fetal brain. This unique tool is based on a general, flexible and realistic setup that includes stochastic fetal movements, thus providing images of the fetal brain throughout maturation comparable to clinical acquisitions. We demonstrate its value to evaluate the robustness and optimize the accuracy of an algorithm for super-resolution fetal brain magnetic resonance imaging from simulated motion-corrupted 2D low-resolution series compared to a synthetic high-resolution reference volume. We also show that the images generated can complement clinical datasets to support data-intensive deep learning methods for fetal brain tissue segmentation

Magnetic Resonance Imaging of the Brain in Moving Subjects. Application of Fetal, Neonatal and Adult Brain Studies

Imaging in the presence of subject motion has been an ongoing challenge for magnetic resonance imaging (MRI). Motion makes MRI data inconsistent, causing artifacts in conventional anatomical imaging as well as invalidating diffusion tensor imaging (DTI) reconstruction. In this thesis some of the important issues regarding the acquisition and reconstruction of anatomical and DTI imaging of moving subjects are addressed; methods to achieve high resolution and high signalto- noise ratio (SNR) volume data are proposed. An approach has been developed that uses multiple overlapped dynamic single shot slice by slice imaging combined with retrospective alignment and data fusion to produce self consistent 3D volume images under subject motion. We term this method as snapshot MRI with volume reconstruction or SVR. The SVR method has been performed successfully for brain studies on subjects that cannot stay still, and in some cases were moving substantially during scanning. For example, awake neonates, deliberately moved adults and, especially, on fetuses, for which no conventional high resolution 3D method is currently available. Fine structure of the in-utero fetal brain is clearly revealed for the first time with substantially improved SNR. The SVR method has been extended to correct motion artifacts from conventional multi-slice sequences when the subject drifts in position during data acquisition. Besides anatomical imaging, the SVR method has also been further extended to DTI reconstruction when there is subject motion. This has been validated successfully from an adult who was deliberately moving and then applied to inutero fetal brain imaging, which no conventional high resolution 3D method is currently available. Excellent fetal brain 3D apparent diffusion coefficient (ADC) maps in high resolution have been achieved for the first time as well as promising fractional Anisotropy (FA) maps. Pilot clinical studies using SVR reconstructed data to study fetal brain development in-utero have been performed. Growth curves for the normally developing fetal brain have been devised by the quantification of cerebral and cerebellar volumes as well as some one dimensional measurements. A Verhulst model is proposed to describe these growth curves, and this approach has achieved a correlation over 0.99 between the fitted model and actual data

Elevation and Deformation Extraction from TomoSAR

3D SAR tomography (TomoSAR) and 4D SAR differential tomography (Diff-TomoSAR) exploit multi-baseline SAR data stacks to provide an essential innovation of SAR Interferometry for many applications, sensing complex scenes with multiple scatterers mapped into the same SAR pixel cell. However, these are still influenced by DEM uncertainty, temporal decorrelation, orbital, tropospheric and ionospheric phase distortion and height blurring. In this thesis, these techniques are explored. As part of this exploration, the systematic procedures for DEM generation, DEM quality assessment, DEM quality improvement and DEM applications are first studied. Besides, this thesis focuses on the whole cycle of systematic methods for 3D & 4D TomoSAR imaging for height and deformation retrieval, from the problem formation phase, through the development of methods to testing on real SAR data. After DEM generation introduction from spaceborne bistatic InSAR (TanDEM-X) and airborne photogrammetry (Bluesky), a new DEM co-registration method with line feature validation (river network line, ridgeline, valley line, crater boundary feature and so on) is developed and demonstrated to assist the study of a wide area DEM data quality. This DEM co-registration method aligns two DEMs irrespective of the linear distortion model, which improves the quality of DEM vertical comparison accuracy significantly and is suitable and helpful for DEM quality assessment. A systematic TomoSAR algorithm and method have been established, tested, analysed and demonstrated for various applications (urban buildings, bridges, dams) to achieve better 3D & 4D tomographic SAR imaging results. These include applying Cosmo-Skymed X band single-polarisation data over the Zipingpu dam, Dujiangyan, Sichuan, China, to map topography; and using ALOS L band data in the San Francisco Bay region to map urban building and bridge. A new ionospheric correction method based on the tile method employing IGS TEC data, a split-spectrum and an ionospheric model via least squares are developed to correct ionospheric distortion to improve the accuracy of 3D & 4D tomographic SAR imaging. Meanwhile, a pixel by pixel orbit baseline estimation method is developed to address the research gaps of baseline estimation for 3D & 4D spaceborne SAR tomography imaging. Moreover, a SAR tomography imaging algorithm and a differential tomography four-dimensional SAR imaging algorithm based on compressive sensing, SAR interferometry phase (InSAR) calibration reference to DEM with DEM error correction, a new phase error calibration and compensation algorithm, based on PS, SVD, PGA, weighted least squares and minimum entropy, are developed to obtain accurate 3D & 4D tomographic SAR imaging results. The new baseline estimation method and consequent TomoSAR processing results showed that an accurate baseline estimation is essential to build up the TomoSAR model. After baseline estimation, phase calibration experiments (via FFT and Capon method) indicate that a phase calibration step is indispensable for TomoSAR imaging, which eventually influences the inversion results. A super-resolution reconstruction CS based study demonstrates X band data with the CS method does not fit for forest reconstruction but works for reconstruction of large civil engineering structures such as dams and urban buildings. Meanwhile, the L band data with FFT, Capon and the CS method are shown to work for the reconstruction of large manmade structures (such as bridges) and urban buildings