Subthreshold rho^0 photoproduction on 3He

A large reduction of the rho^0 mass in the nuclear medium is reported, inferred from dipion photoproduction spectra in the 1 GeV region, for the reaction 3He(gamma,pi+ pi-)X with a 10% duty factor tagged-photon beam and the TAGX multi-particle spectrometer. The energy range covered (800 < E(gamma) < 1120 MeV) lies mostly below the free rho^0 production threshold, a region which is believed sensitive to modifications of light vector-meson properties at nuclear-matter densities. The rho^0 masses extracted from the MC fitting of the data, m*(rho^0) = 642 +/- 40, 669 +/- 32, and 682 +/- 56 MeV/c^2 for E(gamma) in the 800-880, 880-960, and 960-1040 MeV regions respectively, are independently corroborated by a measured, assumption-free, kinematical observable. This mass shift, far exceeding current mean-field driven theoretical predictions, may be suggestive of rho^0 decay within the range of the nucleonic field.Comment: 40 pages, 13 figures, submitted to Phys. Rev.

Comparing ion conductance recordings of synthetic lipid bilayers with cell membranes containing TRP channels

In this article we compare electrical conductance events from single channel recordings of three TRP channel proteins (TRPA1, TRPM2 and TRPM8) expressed in human embryonic kidney cells with channel events recorded on synthetic lipid membranes close to melting transitions. Ion channels from the TRP family are involved in a variety of sensory processes including thermo- and mechano-reception. Synthetic lipid membranes close to phase transitions display channel-like events that respond to stimuli related to changes in intensive thermodynamic variables such as pressure and temperature. TRP channel activity is characterized by typical patterns of current events dependent on the type of protein expressed. Synthetic lipid bilayers show a wide spectrum of electrical phenomena that are considered typical for the activity of protein ion channels. We find unitary currents, burst behavior, flickering, multistep-conductances, and spikes behavior in both preparations. Moreover, we report conductances and lifetimes for lipid channels as described for protein channels. Non-linear and asymmetric current-voltage relationships are seen in both systems. Without further knowledge of the recording conditions, no easy decision can be made whether short current traces originate from a channel protein or from a pure lipid membraneComment: 13 pages, 9 Figure

Overview and Meaning of Identification/Individualization

This article presents two common accounts of the question of inference of source in forensic science. The first, the classic view, leads to direct opinions about source propositions, either categorically or in terms of graded conclusions. The second account focuses on assessing the value of the findings with respect to competing source propositions. It is based on probability theory and represents a preliminary to the most recent, decision-theoretic conceptualization of individualization. This account allows one to critically expose and resolve shortcomings, limitations and scientific drawbacks of the classic view, and to clarify the distinct duties and roles of experts and fact finders

A hybrid BAC physical map of potato: a framework for sequencing a heterozygous genome

<p>Abstract</p> <p>Background</p> <p>Potato is the world's third most important food crop, yet cultivar improvement and genomic research in general remain difficult because of the heterozygous and tetraploid nature of its genome. The development of physical map resources that can facilitate genomic analyses in potato has so far been very limited. Here we present the methods of construction and the general statistics of the first two genome-wide BAC physical maps of potato, which were made from the heterozygous diploid clone RH89-039-16 (RH).</p> <p>Results</p> <p>First, a gel electrophoresis-based physical map was made by AFLP fingerprinting of 64478 BAC clones, which were aligned into 4150 contigs with an estimated total length of 1361 Mb. Screening of BAC pools, followed by the KeyMaps <it>in silico </it>anchoring procedure, identified 1725 AFLP markers in the physical map, and 1252 BAC contigs were anchored the ultradense potato genetic map. A second, sequence-tag-based physical map was constructed from 65919 whole genome profiling (WGP) BAC fingerprints and these were aligned into 3601 BAC contigs spanning 1396 Mb. The 39733 BAC clones that overlap between both physical maps provided anchors to 1127 contigs in the WGP physical map, and reduced the number of contigs to around 2800 in each map separately. Both physical maps were 1.64 times longer than the 850 Mb potato genome. Genome heterozygosity and incomplete merging of BAC contigs are two factors that can explain this map inflation. The contig information of both physical maps was united in a single table that describes hybrid potato physical map.</p> <p>Conclusions</p> <p>The AFLP physical map has already been used by the Potato Genome Sequencing Consortium for sequencing 10% of the heterozygous genome of clone RH on a BAC-by-BAC basis. By layering a new WGP physical map on top of the AFLP physical map, a genetically anchored genome-wide framework of 322434 sequence tags has been created. This reference framework can be used for anchoring and ordering of genomic sequences of clone RH (and other potato genotypes), and opens the possibility to finish sequencing of the RH genome in a more efficient way via high throughput next generation approaches.</p

Was He Guilty as Charged? An Alternative Narrative Based on the Circumstantial Evidence from \u3cem\u3e12 Angry Men\u3c/em\u3e

This essay argues that while 12 Angry Men is typically viewed as a vindication of innocence, careful consideration of the evidence suggests that the jury probably reached the wrong verdict: the circumstantial evidence pointed to guilt! The authors use this insight to discuss the potential impact of circumstantial versus direct evidence on real juries and perhaps the ways that cases are litigated. The essay suggests a number of questions requiring empirical research

Automatic generation of benchmarks for plagiarism detection tools using grammatical evolution

This is the author's version of the work. It is posted here for your personal use. Not for redistribution. The definitive Version of Record was published in {Source Publication}, http://dx.doi.org/10.1145/10.1145/1276958.1277388An extended version of this poster is available at arXiv‘. See: http://arxiv.org/abs/cs/0703134v4Student plagiarism is a major problem in universities worldwide. In this paper, we focus on plagiarism in answers to computer programming assignments, where students mix and/or modify one or more original solutions to obtain counterfeits. Although several software tools have been developed to help the tedious and time consuming task of detecting plagiarism, little has been done to assess their quality, because determining the real authorship of the whole submission corpus is practically impossible for graders. In this article we present a Grammatical Evolution technique which generates benchmarks for testing plagiarism detection tools. Given a programming language, our technique generates a set of original solutions to an assignment, together with a set of plagiarisms of the former set which mimic the basic plagiarism techniques performed by students. The authorship of the submission corpus is predefined by the user, providing a base for the assessment and further comparison of copy-catching tools. We give empirical evidence of the suitability of our approach by studying the behavior of one state-of-the-art detection tool (AC) on four benchmarks coded in APL2, generated with our technique.Work supported by grant TSI2005-08255-C07-06 of the Spanish Ministry of Education and Science