Modeling Quasi-Periodic Signals by a Non-Parametric Model: Application on Fetal ECG Extraction

International audience— Quasi-periodic signals can be modeled by their second order statistics as Gaussian process. This work presents a non-parametric method to model such signals. ECG, as a quasi-periodic signal, can also be modeled by such method which can help to extract the fetal ECG from the maternal ECG signal, using a single source abdominal channel. The prior information on the signal shape, and on the maternal and fetal RR interval, helps to better estimate the parameters while applying the Bayesian principles. The values of the pa-rameters of the method, among which the R-peak instants, are accurately estimated using the Metropolis-Hastings algorithm. This estimation provides very precise values for the R-peaks, so that they can be located even between the existing time samples

Clifford wavelets for fetal ECG extraction

Analysis of the fetal heart rate during pregnancy is essential for monitoring the proper development of the fetus. Current fetal heart monitoring techniques lack the accuracy in fetal heart rate monitoring and features acquisition, resulting in diagnostic medical issues. The challenge lies in the extraction of the fetal ECG from the mother's ECG during pregnancy. This approach has the advantage of being a reliable and non-invasive technique. For this aim, we propose in this paper a wavelet/multi-wavelet method allowing to extract perfectly the feta ECG parameters from the abdominal mother ECG. The method is essentially due to the exploitation of Clifford wavelets as recent variants in the field. We prove that these wavelets are more efficient and performing against classical ones. The experimental results are therefore due to two basic classes of wavelets and multi-wavelets. A first-class is the classical Haar Schauder, and a second one is due to Clifford valued wavelets and multi-wavelets. These results showed that wavelets/multiwavelets are already good bases for the FECG processing, provided that Clifford ones are the best.Comment: 21 pages, 8 figures, 1 tabl

An Application of Gaussian Processes on Ocular Artifact Removal from EEG

International audienceConsequences of eye movements are one of the main inferences that distort the brain EEG recordings. In this paper, a multi-modal approach is used to estimate the ocular artifacts in the EEG: both vertical and horizontal eye movement signals recoded by an eye tracker are used as a reference to denoise the EEG. A Gaussian process, i.e. a second order statistics method, is assumed to model the link between the eye tracker signals and the EEG signals. The proposed method is thus a non-linear extension of the well-known adaptive filtering and can be applied with a single EEG signal contrary to independent component analysis (ICA) which is extensively used. The results show the applicability and the efficiency of this model on the ocular artifact removal

Extraction et débruitage de signaux ECG du foetus.

Les malformations cardiaques congénitales sont la première cause de décès liés à une anomalie congénitale. L electrocardiogramme du fœtus (ECGf), qui est censé contenir beaucoup plus d informations par rapport aux méthodes échographiques conventionnelles, peut être mesuré e par des électrodes sur l abdomen de la mère. Cependant, il est tres faible et mélangé avec plusieurs sources de bruit et interférence y compris l ECG de la mère (ECGm) dont le niveau est très fort. Dans les études précédentes, plusieurs méthodes ont été proposées pour l extraction de l ECGf à partir des signaux enregistrés par des électrodes placées à la surface du corps de la mère. Cependant, ces méthodes nécessitent un nombre de capteurs important, et s avèrent inefficaces avec un ou deux capteurs. Dans cette étude trois approches innovantes reposant sur une paramétrisation algébrique, statistique ou par variables d état sont proposées. Ces trois méthodes mettent en œuvre des modélisations différentes de la quasi-périodicité du signal cardiaque. Dans la première approche, le signal cardiaque et sa variabilité sont modélisés par un filtre de Kalman. Dans la seconde approche, le signal est découpé en fenêtres selon les battements, et l empilage constitue un tenseur dont on cherchera la décomposition. Dans la troisième approche, le signal n est pas modélisé directement, mais il est considéré comme un processus Gaussien, caractérisé par ses statistiques à l ordre deux. Dans les différentes modèles, contrairement aux études précédentes, l ECGm et le (ou les) ECGf sont modélisés explicitement. Les performances des méthodes proposées, qui utilisent un nombre minimum de capteurs, sont évaluées sur des données synthétiques et des enregistrements réels, y compris les signaux cardiaques des fœtus jumeaux.Congenital heart defects are the leading cause of birth defect-related deaths. The fetal electrocardiogram (fECG), which is believed to contain much more information as compared with conventional sonographic methods, can be measured by placing electrodes on the mother s abdomen. However, it has very low power and is mixed with several sources of noise and interference, including the strong maternal ECG (mECG). In previous studies, several methods have been proposed for the extraction of fECG signals recorded from the maternal body surface. However, these methods require a large number of sensors, and are ineffective with only one or two sensors. In this study, state modeling, statistical and deterministic approaches are proposed for capturing weak traces of fetal cardiac signals. These three methods implement different models of the quasi-periodicity of the cardiac signal. In the first approach, the heart rate and its variability are modeled by a Kalman filter. In the second approach, the signal is divided into windows according to the beats. Stacking the windows constructs a tensor that is then decomposed. In a third approach, the signal is not directly modeled, but it is considered as a Gaussian process characterized by its second order statistics. In all the different proposed methods, unlike previous studies, mECG and fECG(s) are explicitly modeled. The performances of the proposed methods, which utilize a minimal number of electrodes, are assessed on synthetic data and actual recordings including twin fetal cardiac signals.SAVOIE-SCD - Bib.électronique (730659901) / SudocGRENOBLE1/INP-Bib.électronique (384210012) / SudocGRENOBLE2/3-Bib.électronique (384219901) / SudocSudocFranceF

ECG Signal Reconstruction on the IoT-Gateway and Efficacy of Compressive Sensing Under Real-time Constraints

Remote health monitoring is becoming indispensable, though, Internet of Things (IoTs)-based solutions have many implementation challenges, including energy consumption at the sensing node, and delay and instability due to cloud computing. Compressive sensing (CS) has been explored as a method to extend the battery lifetime of medical wearable devices. However, it is usually associated with computational complexity at the decoding end, increasing the latency of the system. Meanwhile, mobile processors are becoming computationally stronger and more efficient. Heterogeneous multicore platforms (HMPs) offer a local processing solution that can alleviate the limitations of remote signal processing. This paper demonstrates the real-time performance of compressed ECG reconstruction on ARM's big.LITTLE HMP and the advantages they provide as the primary processing unit of the IoT architecture. It also investigates the efficacy of CS in minimizing power consumption of a wearable device under real-time and hardware constraints. Results show that both the orthogonal matching pursuit and subspace pursuit reconstruction algorithms can be executed on the platform in real time and yield optimum performance on a single A15 core at minimum frequency. The CS extends the battery life of wearable medical devices up to 15.4% considering ECGs suitable for wellness applications and up to 6.6% for clinical grade ECGs. Energy consumption at the gateway is largely due to an active internet connection; hence, processing the signals locally both mitigates system's latency and improves gateway's battery life. Many remote health solutions can benefit from an architecture centered around the use of HMPs, a step toward better remote health monitoring systems.Peer reviewedFinal Published versio

Analog Reconfigurable Circuits

The aim of this paper is to present an overview of a new branch of analog electronics represented by analog reconfigurable circuits. The reconfiguration of analog circuits has been known and used since the beginnings of electronics, but the universal reconfigurable circuits called Field Programmable Analog Arrays (FPAA) have been developed over the last two decades. This paper presents the classification of analog circuit reconfiguration, examples of FPAA solutions obtained as academic projects and commercially available ones, as well as some application examples of the dynamic reconfiguration of FPAA.

Improving Maternal and Fetal Cardiac Monitoring Using Artificial Intelligence

Early diagnosis of possible risks in the physiological status of fetus and mother during pregnancy and delivery is critical and can reduce mortality and morbidity. For example, early detection of life-threatening congenital heart disease may increase survival rate and reduce morbidity while allowing parents to make informed decisions. To study cardiac function, a variety of signals are required to be collected. In practice, several heart monitoring methods, such as electrocardiogram (ECG) and photoplethysmography (PPG), are commonly performed. Although there are several methods for monitoring fetal and maternal health, research is currently underway to enhance the mobility, accuracy, automation, and noise resistance of these methods to be used extensively, even at home. Artificial Intelligence (AI) can help to design a precise and convenient monitoring system. To achieve the goals, the following objectives are defined in this research: The first step for a signal acquisition system is to obtain high-quality signals. As the first objective, a signal processing scheme is explored to improve the signal-to-noise ratio (SNR) of signals and extract the desired signal from a noisy one with negative SNR (i.e., power of noise is greater than signal). It is worth mentioning that ECG and PPG signals are sensitive to noise from a variety of sources, increasing the risk of misunderstanding and interfering with the diagnostic process. The noises typically arise from power line interference, white noise, electrode contact noise, muscle contraction, baseline wandering, instrument noise, motion artifacts, electrosurgical noise. Even a slight variation in the obtained ECG waveform can impair the understanding of the patient's heart condition and affect the treatment procedure. Recent solutions, such as adaptive and blind source separation (BSS) algorithms, still have drawbacks, such as the need for noise or desired signal model, tuning and calibration, and inefficiency when dealing with excessively noisy signals. Therefore, the final goal of this step is to develop a robust algorithm that can estimate noise, even when SNR is negative, using the BSS method and remove it based on an adaptive filter. The second objective is defined for monitoring maternal and fetal ECG. Previous methods that were non-invasive used maternal abdominal ECG (MECG) for extracting fetal ECG (FECG). These methods need to be calibrated to generalize well. In other words, for each new subject, a calibration with a trustable device is required, which makes it difficult and time-consuming. The calibration is also susceptible to errors. We explore deep learning (DL) models for domain mapping, such as Cycle-Consistent Adversarial Networks, to map MECG to fetal ECG (FECG) and vice versa. The advantages of the proposed DL method over state-of-the-art approaches, such as adaptive filters or blind source separation, are that the proposed method is generalized well on unseen subjects. Moreover, it does not need calibration and is not sensitive to the heart rate variability of mother and fetal; it can also handle low signal-to-noise ratio (SNR) conditions. Thirdly, AI-based system that can measure continuous systolic blood pressure (SBP) and diastolic blood pressure (DBP) with minimum electrode requirements is explored. The most common method of measuring blood pressure is using cuff-based equipment, which cannot monitor blood pressure continuously, requires calibration, and is difficult to use. Other solutions use a synchronized ECG and PPG combination, which is still inconvenient and challenging to synchronize. The proposed method overcomes those issues and only uses PPG signal, comparing to other solutions. Using only PPG for blood pressure is more convenient since it is only one electrode on the finger where its acquisition is more resilient against error due to movement. The fourth objective is to detect anomalies on FECG data. The requirement of thousands of manually annotated samples is a concern for state-of-the-art detection systems, especially for fetal ECG (FECG), where there are few publicly available FECG datasets annotated for each FECG beat. Therefore, we will utilize active learning and transfer-learning concept to train a FECG anomaly detection system with the least training samples and high accuracy. In this part, a model is trained for detecting ECG anomalies in adults. Later this model is trained to detect anomalies on FECG. We only select more influential samples from the training set for training, which leads to training with the least effort. Because of physician shortages and rural geography, pregnant women's ability to get prenatal care might be improved through remote monitoring, especially when access to prenatal care is limited. Increased compliance with prenatal treatment and linked care amongst various providers are two possible benefits of remote monitoring. If recorded signals are transmitted correctly, maternal and fetal remote monitoring can be effective. Therefore, the last objective is to design a compression algorithm that can compress signals (like ECG) with a higher ratio than state-of-the-art and perform decompression fast without distortion. The proposed compression is fast thanks to the time domain B-Spline approach, and compressed data can be used for visualization and monitoring without decompression owing to the B-spline properties. Moreover, the stochastic optimization is designed to retain the signal quality and does not distort signal for diagnosis purposes while having a high compression ratio. In summary, components for creating an end-to-end system for day-to-day maternal and fetal cardiac monitoring can be envisioned as a mix of all tasks listed above. PPG and ECG recorded from the mother can be denoised using deconvolution strategy. Then, compression can be employed for transmitting signal. The trained CycleGAN model can be used for extracting FECG from MECG. Then, trained model using active transfer learning can detect anomaly on both MECG and FECG. Simultaneously, maternal BP is retrieved from the PPG signal. This information can be used for monitoring the cardiac status of mother and fetus, and also can be used for filling reports such as partogram

Human Health Engineering Volume II

In this Special Issue on “Human Health Engineering Volume II”, we invited submissions exploring recent contributions to the field of human health engineering, i.e., technology for monitoring the physical or mental health status of individuals in a variety of applications. Contributions could focus on sensors, wearable hardware, algorithms, or integrated monitoring systems. We organized the different papers according to their contributions to the main parts of the monitoring and control engineering scheme applied to human health applications, namely papers focusing on measuring/sensing physiological variables, papers highlighting health-monitoring applications, and examples of control and process management applications for human health. In comparison to biomedical engineering, we envision that the field of human health engineering will also cover applications for healthy humans (e.g., sports, sleep, and stress), and thus not only contribute to the development of technology for curing patients or supporting chronically ill people, but also to more general disease prevention and optimization of human well-being

Advanced Sensing and Image Processing Techniques for Healthcare Applications

This Special Issue aims to attract the latest research and findings in the design, development and experimentation of healthcare-related technologies. This includes, but is not limited to, using novel sensing, imaging, data processing, machine learning, and artificially intelligent devices and algorithms to assist/monitor the elderly, patients, and the disabled population