1,381 research outputs found
Innovative in silico approaches to address avian flu using grid technology
The recent years have seen the emergence of diseases which have spread very
quickly all around the world either through human travels like SARS or animal
migration like avian flu. Among the biggest challenges raised by infectious
emerging diseases, one is related to the constant mutation of the viruses which
turns them into continuously moving targets for drug and vaccine discovery.
Another challenge is related to the early detection and surveillance of the
diseases as new cases can appear just anywhere due to the globalization of
exchanges and the circulation of people and animals around the earth, as
recently demonstrated by the avian flu epidemics. For 3 years now, a
collaboration of teams in Europe and Asia has been exploring some innovative in
silico approaches to better tackle avian flu taking advantage of the very large
computing resources available on international grid infrastructures. Grids were
used to study the impact of mutations on the effectiveness of existing drugs
against H5N1 and to find potentially new leads active on mutated strains. Grids
allow also the integration of distributed data in a completely secured way. The
paper presents how we are currently exploring how to integrate the existing
data sources towards a global surveillance network for molecular epidemiology.Comment: 7 pages, submitted to Infectious Disorders - Drug Target
Supporting UK-wide e-clinical trials and studies
As clinical trials and epidemiological studies become increasingly large, covering wider (national) geographical areas and involving ever broader populations, the need to provide an information management infrastructure that can support such endeavours is essential. A wealth of clinical data now exists at varying levels of care (primary care, secondary care, etc.). Simple, secure access to such data would greatly benefit the key processes involved in clinical trials and epidemiological studies: patient recruitment, data collection and study management. The Grid paradigm provides one model for seamless access to such data and support of these processes.
The VOTES project (Virtual Organisations for Trials and Epidemiological Studies) is a collaboration between several UK institutions to implement a generic framework that effectively leverages the available health-care information across the UK to support more efficient gathering and processing of trial information. The structure of the information available in the health-care domain in the UK itself varies broadly in-line with the national boundaries of the constituent states (England, Scotland, Wales and Northern Ireland). Technologies must address these political boundaries and the impact these boundaries have in terms of for example, information governance, policies, and of course large-scale heterogeneous distribution of the data sets themselves.
This paper outlines the methodology in implementing the framework between three specific data sources that serve as useful case studies: Scottish data from the Scottish Care Information (SCI) Store data repository, data on the General Practice Research Database (GPRD) diabetes trial at Imperial College London, and benign prostate hypoplasia (BPH) data from the University of Nottingham. The design, implementation and wider research issues are discussed along with the technological challenges encountered in the project in the application of Grid technologies
Restructuring as a Clue to Unleashing Nigeria’s Potentials and Prosperity
The continuous misgivings about Nigeria’s developmental trajectory predate Nigeria’s independence. The clues that can unravel and demystify the mystery surrounding the continuous retardation of socio-political and economic well-being of Nigeria have over the years become a tall order. Using the qualitative method, this paper succulently highlighted restructuring as a veritable panacea for promoting peaceful co-existence amongst ethnic nationalities, and also encourages healthy competition among federating units or states. This paper further discussed restructuring as it relates to resource control by sub-national government. It recommended power devolution and deloading of the exclusive list of 1999 constitution as amended and galvanizing the states and local government towards assuming more governmental responsibilities.
Keywords: Federalism, Political Restructuring, Clue, Devolution, Autonomy
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Capturing Scientific Knowledge on Medical Risk Factors
In this paper, we describe a model for representing scientific knowledge of risk factors in medicine in an explicit format which enables its use for automated reasoning. The resulting model supports linking the conclusions of up-to-date clinical research with data relating to individual patients. This model, which we have implemented as an ontology-based system using Linked Data, enables the capture of risk factor knowledge and serves as a translational research tool to apply that knowledge to assist with patient treatment, lifestyle, and education. Knowledge captured using this model can be disseminated for other intelligent systems to use for a variety of purposes, for example, to explore the state of the available medical knowledge
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Feeling the squeeze? Tabbies or tigers: the case of social enterprises contracting in the fields of recycling and work integration
Current UK policy is encouraging the identification, emergence, transmutation or invention of third sector organisations that will have a social enterprise orientation with a particular focus on them as vehicles for the delivery of public services (Audit Commission 2005). This can be seen as part of the new governance agenda (Taylor, Wilkinson and Craig 2001, Kendal 2003, Stoker 2004) the form of which is still emergent. One view of governance refers to a 'hollowing out' of state powers (Rhodes, 1997) and a shift from state control to co-ordination using mechanisms such as networks and partnerships to bring together the public, private and third sector as well as community actors and citizens in reforming services. Local Authority white paper (2006) promised further decentralisation moving functions downwards to special purpose bodies and outwards to agencies and communities. The new Local Government White Paper emphasises the role of community engagement, partnership arrangements and devolved budgets with voluntary organisations at the local level (NCVO 2006: 2-3). Such processes are aimed both at both private and third sector providers.
In this new distributed system of governance partnership and collaboration plays an important role in the implementation of social goods although these processes are never unproblematic (Huxham & Vangen 2000; Taylor Taylor, Wilkinson and Craig 2001). Nevertheless the contracting out processes continue to gather speed: with recycling and waste, care, leisure services, work advice, health services, prison and probation at various stages in the continuum of change.
Against this background the role and form of social enterprise organisations appears at times to be assumed to be 'heterogeneous' and 'good' with all organisations tending towards similar development trajectories with uniform support needs. What is often not distinguished so clearly are the differing types of social enterprise; the different sub-sectors of the economy they are operating in; the variety of markets and funding regimes they are involved in; the different partnership regimes they are embedded within; and their different cultures and connection to local communities. All of these factors have implications for what types of organisations (large/small social enterprise; local/national organisations, and even social enterprise or private organisation) are favoured in the contracting processes and how such processes may affect their wider mission and ethos. Social enterprises are sometimes treated by policy makers, and at times by leaders, practitioners and researchers within the sector as if they were one thing. Crudely we might say they are treated as if they are all cats when in reality some are tigers and some are tabbys – with every breed in between. Nevertheless, despite the heterogeneity of the social enterprise scene we are seeing evidence of a convergence of form in contracting processes which, we argue, tends to favour the tigers and squeeze the tabbys.
This paper reports on recent empirical research and analysis in 2 sub fields of social enterprise activity: (a) the delivery of waste and recycling services (Slater 2006) and (b) the delivery of work integration and advice activities for the disadvantaged (Aiken 2006, 2007)
Promoting universal financial protection: constraints and enabling factors in scaling-up coverage with social health insurance in Nigeria.
BACKGROUND: The National Health Insurance Scheme (NHIS) in Nigeria was launched in 2005 as part of efforts by the federal government to achieve universal coverage using financial risk protection mechanisms. However, only 4% of the population, and mainly federal government employees, are currently covered by health insurance and this is primarily through the Formal Sector Social Health Insurance Programme (FSSHIP) of the NHIS. This study aimed to understand why different state (sub-national) governments decided whether or not to adopt the FSSHIP for their employees. METHODS: This study used a comparative case study approach. Data were collected through document reviews and 48 in-depth interviews with policy makers, programme managers, health providers, and civil servant leaders. RESULTS: Although the programme's benefits seemed acceptable to state policy makers and the intended beneficiaries (employees), the feasibility of employer contributions, concerns about transparency in the NHIS and the role of states in the FSSHIP, the roles of policy champions such as state governors and resistance by employees to making contributions, all influenced the decision of state governments on adoption. Overall, the power of state governments over state-level health reforms, attributed to the prevailing system of government that allows states to deliberate on certain national-level policies, enhanced by the NHIS legislation that made adoption voluntary, enabled states to adopt or not to adopt the program. CONCLUSIONS: The study demonstrates and supports observations that even when the content of a programme is generally acceptable, context, actor roles, and the wider implications of programme design on actor interests can explain decision on policy adoption. Policy implementers involved in scaling-up the NHIS programme need to consider the prevailing contextual factors, and effectively engage policy champions to overcome known challenges in order to encourage adoption by sub-national governments. Policy makers and implementers in countries scaling-up health insurance coverage should, early enough, develop strategies to overcome political challenges inherent in the path to scaling-up, to avoid delay or stunting of the process. They should also consider the potential pitfalls of reforms that first focus on civil servants, especially when the use of public funds potentially compromises coverage for other citizens
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