1,384 research outputs found
Exploring Contextual Relationships for Cervical Abnormal Cell Detection
Cervical abnormal cell detection is a challenging task as the morphological
discrepancies between abnormal and normal cells are usually subtle. To
determine whether a cervical cell is normal or abnormal, cytopathologists
always take surrounding cells as references to identify its abnormality. To
mimic these behaviors, we propose to explore contextual relationships to boost
the performance of cervical abnormal cell detection. Specifically, both
contextual relationships between cells and cell-to-global images are exploited
to enhance features of each region of interest (RoI) proposals. Accordingly,
two modules, dubbed as RoI-relationship attention module (RRAM) and global RoI
attention module (GRAM), are developed and their combination strategies are
also investigated. We establish a strong baseline by using Double-Head Faster
R-CNN with feature pyramid network (FPN) and integrate our RRAM and GRAM into
it to validate the effectiveness of the proposed modules. Experiments conducted
on a large cervical cell detection dataset reveal that the introduction of RRAM
and GRAM both achieves better average precision (AP) than the baseline methods.
Moreover, when cascading RRAM and GRAM, our method outperforms the
state-of-the-art (SOTA) methods. Furthermore, we also show the proposed feature
enhancing scheme can facilitate both image-level and smear-level
classification. The code and trained models are publicly available at
https://github.com/CVIU-CSU/CR4CACD.Comment: 10 pages, 14 tables, and 3 figure
Multi-class Cervical Cancer Classification using Transfer Learning-based Optimized SE-ResNet152 model in Pap Smear Whole Slide Images
Among the main factors contributing to death globally is cervical cancer, regardless of whether it can be avoided and treated if the afflicted tissues are removed early. Cervical screening programs must be made accessible to everyone and effectively, which is a difficult task that necessitates, among other things, identifying the population\u27s most vulnerable members. Therefore, we present an effective deep-learning method for classifying the multi-class cervical cancer disease using Pap smear images in this research. The transfer learning-based optimized SE-ResNet152 model is used for effective multi-class Pap smear image classification. The reliable significant image features are accurately extracted by the proposed network model. The network\u27s hyper-parameters are optimized using the Deer Hunting Optimization (DHO) algorithm. Five SIPaKMeD dataset categories and six CRIC dataset categories constitute the 11 classes for cervical cancer diseases. A Pap smear image dataset with 8838 images and various class distributions is used to evaluate the proposed method. The introduction of the cost-sensitive loss function throughout the classifier\u27s learning process rectifies the dataset\u27s imbalance. When compared to prior existing approaches on multi-class Pap smear image classification, 99.68% accuracy, 98.82% precision, 97.86% recall, and 98.64% F1-Score are achieved by the proposed method on the test set. For automated preliminary diagnosis of cervical cancer diseases, the proposed method produces better identification results in hospitals and cervical cancer clinics due to the positive classification results
LESS: Label-efficient Multi-scale Learning for Cytological Whole Slide Image Screening
In computational pathology, multiple instance learning (MIL) is widely used
to circumvent the computational impasse in giga-pixel whole slide image (WSI)
analysis. It usually consists of two stages: patch-level feature extraction and
slide-level aggregation. Recently, pretrained models or self-supervised
learning have been used to extract patch features, but they suffer from low
effectiveness or inefficiency due to overlooking the task-specific supervision
provided by slide labels. Here we propose a weakly-supervised Label-Efficient
WSI Screening method, dubbed LESS, for cytological WSI analysis with only
slide-level labels, which can be effectively applied to small datasets. First,
we suggest using variational positive-unlabeled (VPU) learning to uncover
hidden labels of both benign and malignant patches. We provide appropriate
supervision by using slide-level labels to improve the learning of patch-level
features. Next, we take into account the sparse and random arrangement of cells
in cytological WSIs. To address this, we propose a strategy to crop patches at
multiple scales and utilize a cross-attention vision transformer (CrossViT) to
combine information from different scales for WSI classification. The
combination of our two steps achieves task-alignment, improving effectiveness
and efficiency. We validate the proposed label-efficient method on a urine
cytology WSI dataset encompassing 130 samples (13,000 patches) and FNAC 2019
dataset with 212 samples (21,200 patches). The experiment shows that the
proposed LESS reaches 84.79%, 85.43%, 91.79% and 78.30% on a urine cytology WSI
dataset, and 96.88%, 96.86%, 98.95%, 97.06% on FNAC 2019 dataset in terms of
accuracy, AUC, sensitivity and specificity. It outperforms state-of-the-art MIL
methods on pathology WSIs and realizes automatic cytological WSI cancer
screening.Comment: This paper was submitted to Medical Image Analysis. It is under
revie
Nuclei & Glands Instance Segmentation in Histology Images: A Narrative Review
Instance segmentation of nuclei and glands in the histology images is an
important step in computational pathology workflow for cancer diagnosis,
treatment planning and survival analysis. With the advent of modern hardware,
the recent availability of large-scale quality public datasets and the
community organized grand challenges have seen a surge in automated methods
focusing on domain specific challenges, which is pivotal for technology
advancements and clinical translation. In this survey, 126 papers illustrating
the AI based methods for nuclei and glands instance segmentation published in
the last five years (2017-2022) are deeply analyzed, the limitations of current
approaches and the open challenges are discussed. Moreover, the potential
future research direction is presented and the contribution of state-of-the-art
methods is summarized. Further, a generalized summary of publicly available
datasets and a detailed insights on the grand challenges illustrating the top
performing methods specific to each challenge is also provided. Besides, we
intended to give the reader current state of existing research and pointers to
the future directions in developing methods that can be used in clinical
practice enabling improved diagnosis, grading, prognosis, and treatment
planning of cancer. To the best of our knowledge, no previous work has reviewed
the instance segmentation in histology images focusing towards this direction.Comment: 60 pages, 14 figure
Machine Learning Techniques for Cervigram Image Analysis
Machine learning is a popular technology widely used to solve a lot of problems in various areas in recent decades. In this work, we applied machine learning techniques to the problems of medical image analysis, especially cervigram image analysis. Combined with techniques developed in computer vision, we represent cervigram image data in the form of a combination of texture feature vector and color feature vector. We treat the task of detecting Cervical Intraepithelial Neoplasia (CIN) level as a classification problem in the view of machine learning and apply several popular machine learning classifiers to predict the categories. Furthermore, under receiver operating characteristic (ROC) curve as our performance measure, we do a comprehensive comparison among seven machine learning classification algorithms to see which ones might be suitable models for this kind of problems. From our experiments, we conjecture that the machine learning techniques can be a useful tool and ensemble-tree based models like Random Forest, Gradient Boosting Decision Tree and Adaboost outperform other algorithms for this task
Spinal cord gray matter segmentation using deep dilated convolutions
Gray matter (GM) tissue changes have been associated with a wide range of
neurological disorders and was also recently found relevant as a biomarker for
disability in amyotrophic lateral sclerosis. The ability to automatically
segment the GM is, therefore, an important task for modern studies of the
spinal cord. In this work, we devise a modern, simple and end-to-end fully
automated human spinal cord gray matter segmentation method using Deep
Learning, that works both on in vivo and ex vivo MRI acquisitions. We evaluate
our method against six independently developed methods on a GM segmentation
challenge and report state-of-the-art results in 8 out of 10 different
evaluation metrics as well as major network parameter reduction when compared
to the traditional medical imaging architectures such as U-Nets.Comment: 13 pages, 8 figure
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