Time-lapse capacitive resistivity imaging: a new technology concept for the monitoring of permafrost

The British Geological Survey, in partnership with the Universities of Sussex and Bonn, is investigating and seeking to prove a new technology concept for the non-invasive volumetric imaging and routine temporal monitoring of the thermal state of permafrost (Figure 1), a key indicator of global climate change. Capacitive Resistivity Imaging (CRI), a technique based upon a low-frequency, capacitively-coupled measurement approach (Kuras et al., 2006) is applied in order to emulate Electrical Resistivity Tomography (ERT) methodology, but without the need for galvanic contact on frozen soils or rocks. Recent work has shown that temperature-calibrated ERT using galvanic sensors (Figure 2) is capable of imaging recession and re-advance of rock permafrost in response to the ambient temperature regime. However, the use of galvanic sensors can lead to significant practical limitations on field measurements due to high levels of and large variations in contact resistances between sensors and the host material as it freezes and thaws Figure 3). The capacitive technology developed here overcomes this problem and provides a more robust means of making high-quality resistance measurements with permanently installed sensors over time. Reducing the uncertainty associated with uncontrolled noise from galvanic sensors increases the value of time-lapse ERT datasets in the context of monitoring permafrost

Finite element modelling of electrostatic fields in process tomography capacitive electrode systems for flow response evaluation

Various aspects and results of 2-D finite element (FE) modeling of electrostatic fields in 12-electrode capacitive systems for two-phase flow imaging are described. The capacitive technique relies on changes in capacitances between electrodes (mounted on the outer surface of the flow pipe) due to the change in permittivities of flow components. The measured capacitances between various electrode pairs and the field computation data are used to reconstruct the cross sectional image of the flow components. FE modeling of the electric field is necessary to optimize design variables and evaluate the system response to various flow regimes, likely to be encountered in practice. Results are presented in terms of normalized capacitances for various flow regimes. The effects of key geometric parameters of the electrode system are presented and analyzed

Thermal dosimetry for bladder hyperthermia treatment. An overview.

The urinary bladder is a fluid-filled organ. This makes, on the one hand, the internal surface of the bladder wall relatively easy to heat and ensures in most cases a relatively homogeneous temperature distribution; on the other hand the variable volume, organ motion, and moving fluid cause artefacts for most non-invasive thermometry methods, and require additional efforts in planning accurate thermal treatment of bladder cancer. We give an overview of the thermometry methods currently used and investigated for hyperthermia treatments of bladder cancer, and discuss their advantages and disadvantages within the context of the specific disease (muscle-invasive or non-muscle-invasive bladder cancer) and the heating technique used. The role of treatment simulation to determine the thermal dose delivered is also discussed. Generally speaking, invasive measurement methods are more accurate than non-invasive methods, but provide more limited spatial information; therefore, a combination of both is desirable, preferably supplemented by simulations. Current efforts at research and clinical centres continue to improve non-invasive thermometry methods and the reliability of treatment planning and control software. Due to the challenges in measuring temperature across the non-stationary bladder wall and surrounding tissues, more research is needed to increase our knowledge about the penetration depth and typical heating pattern of the various hyperthermia devices, in order to further improve treatments. The ability to better determine the delivered thermal dose will enable clinicians to investigate the optimal treatment parameters, and consequentially, to give better controlled, thus even more reliable and effective, thermal treatments

The effect of modulated electro-hyperthermia on local disease control in HIV-positive and -negative cervical cancer women in South Africa : early results from a phase III randomised controlled trial

Background : The global burden of cervical cancer remains high with the highest morbidity and mortality rates reported in developing countries. Hyperthermia as a chemo- and radiosensitiser has shown to improve treatment outcomes. This is an analysis of the local control results at six months post-treatment of patients enrolled in an ongoing study investigating the effects of the addition of modulated electro-hyperthermia (mEHT) to chemoradiotherapy for the treatment of HIV-positive and -negative cervical cancer patients in a low-resource setting. Methods : This ongoing Phase III randomised controlled trial, conducted at a state hospital in Johannesburg, South Africa, was registered with the appropriate ethics committee. After signing an informed consent, participants with FIGO stages IIB to IIIB squamous cell carcinoma of the cervix were randomised to receive chemoradiotherapy with/without mEHT using a secure online random-sampling tool (stratum: HIV status) accounting for age and stage. Reporting physicians were blind to treatment allocation. HIV-positive participants on antiretroviral treatment, or with a CD4 count >200cell/mu L were included. mEHT was administered 2/weekly immediately before external beam radiation. The primary end point is local disease control (LDC) and secondary endpoints are toxicity; quality of life analysis; and two year survival. We report on six month LDC, including nodes visualised in the radiation field on F-18-FDG PET/CT (censored for six month survival), and six month local disease free survival (LDFS) (based on intention to treat). Trial status: Recruitment closed (ClinicalTrials. gov: NCT03332069). Results : 271 participants were recruited between January 2014 and November 2017, of which 210 were randomised for trial and 202 were available for analysis at six months post-treatment (mEHT: n = 101; Control: n = 101). Six month LDFS was higher in the mEHT Group (n = 39 [38.6%]), than in the Control Group (n = 20[19.8%]); p = 0.003). LDC was also higher in the mEHT Group (n = 40[45.5%]) than the Control Group (n = 20[24.1%]); (p = 0.003). Conclusion : Our results show that mEHT is effective as a chemo-radiosensitiser for cervical cancer, even in high risk a patients and resource-constrained settings

Fault location and diagnosis in a medium voltage EPR power cable

This paper presents a case study on fault location, characterization and diagnosis in a length of shielded 11 kV medium voltage ethylene-propylene rubber (EPR) power cable. The defect was identified on-site as a low resistance fault occurring between the sheath and the core. A 43 m section was removed for further analysis. The fault resistance was characterized and the location of the defect pinpointed to within a few cm using a combination of time-difference-of-arrival location and infra-red imaging. A combination of X-ray computed tomography, scanning electron microscopy and energy dispersive X-ray spectroscopy were then applied to characterize any abnormalities in the dielectric surrounding the breakdown region. A significant number of high density contaminants were found to be embedded in the dielectric layer, having an average diameter of the order of 100 um, a maximum diameter of 310 um and an average density of 1 particle per 2.28 mm3 . Scanning electron microscopy and energy-dispersive X-ray spectroscopy were used to determine the geometry and elemental composition of some initial contaminant samples. It was concluded that contamination of the EPR layer, combined with an observed eccentricity of the cable’s core and sheath resulting in a reduced insulation gap, may have led to an electric field concentration in the region of the defect sufficient to initiate breakdown. Preventative strategies are discussed for similar families of cables, including more stringent dielectric testing requirements at the manufacturing stage and PD monitoring to detect incipient failure

RTM production monitoring of the A380 hinge arm droop nose mechanism: a multi-sensor approach

his research presents a case study of production monitoring on an aerospace composite component: the hinge arm of the droop nose mechanism on the Airbus A380 wing leading edge. A sensor network composed of Fibre Bragg Gratings, capacitive sensors for cure monitoring and thermocouples was embedded in its fibre reinforced lay-up and measurements were acquired throughout its Resin Transfer Moulding production process. Two main challenges had to be overcome: first, the integration of the sensor lines in the existing Resin Transfer Moulding mould without modifying it; second, the demoulding of the component without damaging the sensor lines. The proposed embedding solution has proved successful. The wavelength shifts of the Fibre Bragg Gratings were observed from the initial production stages, over the resin injection, the complete curing of the resin and the cooling-down prior to demoulding. The sensors proved to be sensitive to detecting the resin flow front, vacuum and pressure increase into the mould and the temperature increase caused by the resin curing. Measurements were also acquired during the post-curing cycle. Residual strains during all steps of the process were derived from the sensors’ wavelength shift, showing values up to 0.2% in compression. Moreover, the capacitive sensors were able to follow-up the curing degree during the production process. The sensors proved able to detect the resin flow front, whereas thermocouples could not measure an appreciable increase of temperature due to the fact that the resin had the same temperature as the mould

Single-Shot Waterless Low-Profile Photoacoustic System: Near-Field Volumetric Imaging In Vivo for Blood Vessels Based on Capacitive Micromachined Ultrasonic Transducer (CMUT)

Intensive research on photoacoustics (PA) for imaging of the living human body, including the skin, vessels, and tumors, has recently been conducted. We propose a PA measurement system based on a capacitive micromachined ultrasonic transducer (CMUT) with waterless coupling, short measurement time (��1 s), backward light irradiation, and a low-profile ultrasonic receiver unit (��1 cm). We fabricate a 64-element CMUT ring array with 6.2 mm diameter and 10.4 MHz center frequency in air, and 100% yield and uniform element response. To validate the PA tissue characterization, we employ pencil lead and red ink as solid and liquid models, respectively, and a living body to target moles and vessels. The system implements a near-field imaging system consisting of a 6 mm polydimethylsiloxane (PDMS) matching layer between the object and CMUT, which has a 3.7 MHz center frequency in PDMS. Experiments were performed in a waterless contact on the PDMS and the laser was irradiated with a 1 cm diameter. The experimental results show the feasibility of this near-field PA imaging system for position and depth detection of skin, mole, vessel cells, etc. Therefore, a system applicable to a low-profile compact biomedical device is presented.National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP, Ministry of Science, ICT & Future Planning) (No. 2016R1E1A2915630); National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIT) (No. 2018R1A5A7025522)

Simplifying the hardware requirements for fast neural EIT of peripheral nerves

OBJECTIVE: The main objective of this study was to assess the feasibility of lowering the hardware requirements for fast neural EIT in order to support the distribution of this technique. Specifically, the feasibility of replacing the commercial modules present in the existing high-end setup with compact and cheap customized circuitry was assessed. APPROACH: Nerve EIT imaging was performed on rat sciatic nerves with both our standard ScouseTom setup and a customized version in which commercial benchtop current sources were replaced by custom circuitry. Electrophysiological data and images collected in the same experimental conditions with the two setups were compared. Data from the customized setup was subject to a down-sampling analysis to simulate the use of a recording module with lower specifications. MAIN RESULTS: Compound action potentials (573±287µV and 487±279µV, p=0.28) and impedance changes (36±14µV and 31±16µV, p=0.49) did not differ significantly when measured using commercial high-end current sources or our custom circuitry, respectively. Images reconstructed from both setups showed neglibile (<1voxel, i.e. 40µm) difference in peak location and a high degree of correlation (R2=0.97). When down-sampling from 24 to 16 bits ADC resolution and from 100KHz to 50KHz sampling frequency, signal-to-noise ratio showed acceptable decrease (<-20%), and no meaningful image quality loss was detected (peak location difference <1voxel, pixel-by-pixel correlation R2=0.99). SIGNIFICANCE: The technology developed for this study greatly reduces the cost and size of a fast neural EIT setup without impacting quality and thus promotes the adoption of this technique by the neuroscience research community