1,928 research outputs found
Feasibility of a wearable reflectometric system for sensing skin hydration
One of the major goals of Health 4.0 is to offer personalized care to patients, also through real-time, remote monitoring of their biomedical parameters. In this regard, wearable monitoring systems are crucial to deliver continuous appropriate care. For some biomedical parameters, there are a number of well established systems that offer adequate solutions for real-time, continuous patient monitoring. On the other hand, monitoring skin hydration still remains a challenging task. The continuous monitoring of this physiological parameter is extremely important in several contexts, for example for athletes, sick people, workers in hostile environments or for the elderly.
State-of-the-art systems, however, exhibit some limitations, especially related with the possibility of continuous, real-time monitoring. Starting from these considerations, in this work, the feasibility of an innovative time-domain reflectometry (TDR)-based wearable, skin hydration sensing system for real-time, continuous monitoring of skin hydration level was investigated. The applicability of the proposed system was demonstrated, first, through experimental tests on reference substances, then, directly on human skin. The obtained results demonstrate the TDR technique and the proposed system holds unexplored potential for the aforementioned purposes
Feasibility of a wearable reflectometric system for sensing skin hydration
none7noOne of the major goals of Health 4.0 is to offer personalized care to patients, also through real-time, remote monitoring of their biomedical parameters. In this regard, wearable monitoring systems are crucial to deliver continuous appropriate care. For some biomedical parameters, there are a number of well established systems that offer adequate solutions for real-time, continuous patient monitoring. On the other hand, monitoring skin hydration still remains a challenging task. The continuous monitoring of this physiological parameter is extremely important in several contexts, for example for athletes, sick people, workers in hostile environments or for the elderly. State-of-the-art systems, however, exhibit some limitations, especially related with the possibility of continuous, real-time monitoring. Starting from these considerations, in this work, the feasibility of an innovative time-domain reflectometry (TDR)-based wearable, skin hydration sensing system for real-time, continuous monitoring of skin hydration level was investigated. The applicability of the proposed system was demonstrated, first, through experimental tests on reference substances, then, directly on human skin. The obtained results demonstrate the TDR technique and the proposed system holds unexplored potential for the aforementioned purposes.openSchiavoni R.; Monti Giuseppina.; Piuzzi E.; Tarricone L.; Tedesco A.; De Benedetto E.; Cataldo A.Schiavoni, R.; Monti, Giuseppina.; Piuzzi, E.; Tarricone, L.; Tedesco, A.; De Benedetto, E.; Cataldo, A
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Review of Advances in the Measurement of Skin Hydration Based on Sensing of Optical and Electrical Tissue Properties
The presence of water in the skin is crucial for maintaining the properties and functions of the skin, in particular its outermost layer, known as the stratum corneum, which consists of a lipid barrier. External exposures can affect the skin’s hydration levels and in turn, alter its mechanical and physical properties. Monitoring these alterations in the skin’s water content can be applicable in clinical, cosmetic, athletic and personal settings. Many techniques measuring this parameter have been investigated, with electrical-based methods currently being widely used in commercial devices. Furthermore, the exploration of optical techniques to measure hydration is growing due to the outcomes observed through the penetration of light at differing levels. This paper comprehensively reviews such measurement techniques, focusing on recent experimental studies and state-of-the-art devices
Epidermal sensors for monitoring skin physiology
Wearable sensors are revolutionizing personalised healthcare and have continuously progressed over the years in both research and commercialization. However, most efforts on wearable sensors have been focused on tracking movement, spatial position and continuous monitoring of vital signs such as heart rate or respiration rate. Recently, there is a demand to obtain biochemical information from the body using wearables. This demand stems from an individuals’ desire for improved personal health awareness as well as the drive for doctors to continuously obtain medical information for a patients’ disease management. Epidermal sensors are a sub-class of wearable sensors that can intimately integrate with skin and have the potential for monitoring physical changes as well as detecting biomarkers within skin that can be related to human health. The holy grail for these types of sensors is to achieve continuous real-time monitoring of the state of an individual and the development of these sensors are paving the way towards personalised healthcare. However, skin is highly anisotropic which makes it challenging to keep epidermal sensors in consistent contact with skin. It is important that these sensors remain in contact with skin in order to measure its electrical properties and acquire high fidelity signals.
The key objective of this thesis is to develop thin conformable, stretchable epidermal sensors for tracking changes in skin physiology. The initial iteration of the screen printed epidermal sensor comprised of a flexible silver film. Impedance spectroscopy was used to understand the electrical signals generated on skin and it was used to measure relative changes due to varying water content. However, this iteration was more suited for single use. The next chapters explore different ink formulations and adherence methodologies to enhance the epidermal sensors adherence to skin. Impedance spectroscopy was used to characterise the electrical signals from these different epidermal sensor iterations, while tensile testing and on-body assessment was used to characterise its mechanical properties. The final chapter focused on investigating the use of phenyl boronic acid (PBA) functionalized hydrogels to modify the epidermal sensor with responsive hydrogel materials to enable chemical sensing of analytes relevant to skin physiology. Impedance spectroscopy was used to characterise and understand the electrical signals generated by the binding interaction of the PBA and analytes using the sensor. Overall, the work demonstrates the challenges of developing these epidermal sensors as well as presenting their potential for continuous monitoring of human skin in the future
Study of the Characteristics of Scalp Electroencephalography Sensing
Ph.DDOCTOR OF PHILOSOPH
Advances in materials strategies, circuit designs, and informatics for wearable, flexible and stretchable electronics with medical and robotic applications
The future of medical electronics should be flexible, stretchable and skin-integrated. While modern electronics become increasing smaller, faster and energy efficient, the designs remain bulky and rigid due to materials and processing limitations. The miniaturization of health monitoring devices in wearable form resembles a significant progress towards the next-generation medical electronics. However, there are still key challenges in these wearable electronics associated with medical-grade sensing precision, reliable wireless powering, and materials strategy for skin-integration. Here, I present a series of systematic studies from materials strategies, circuit design to signal processing on skin-mounted electronic wearable devices. Several types of Epidermal Electronic Systems (EES) develop applications in dermatology, cardiology, rehabilitation, and wireless powering. For skin hydration measurement, fundamental studies of electrode configurations and skin-electrode impedance reveal the optimal sensor design. Furthermore, wireless operation of hydration sensor was made possible with direct integration on skin, and on porous substrates that collect and analyze sweats. Additionally, I present an epidermal multi-functional sensing platform that could provide a control-feedback loop through electromyogram and current stimulation; and a mechano-acoustic device that could capture vibrations from muscle, heart, and throat as diagnostic tools or human-machine interface. I developed a modularized epidermal radio-frequency energy transfer epidermal device to eliminate batteries and power cables for wearable electronics. Finally, I present a clinical study that validates a commercialized ESS on patients with nerve disorders for electromyography monitoring during peripheral nerve and spinal cord surgeries
Innovative IoT Solutions and Wearable Sensing Systems for Monitoring Human Biophysical Parameters: A Review
none3noDigital and information technologies are heavily pervading several aspects of human activities, improving our life quality. Health systems are undergoing a real technological revolution, radically changing how medical services are provided, thanks to the wide employment of the Internet of Things (IoT) platforms supporting advanced monitoring services and intelligent inferring systems.
This paper reports, at first, a comprehensive overview of innovative sensing systems for monitoring
biophysical and psychophysical parameters, all suitable for integration with wearable or portable
accessories. Wearable devices represent a headstone on which the IoT-based healthcare platforms
are based, providing capillary and real-time monitoring of patient’s conditions. Besides, a survey of
modern architectures and supported services by IoT platforms for health monitoring is presented,
providing useful insights for developing future healthcare systems. All considered architectures
employ wearable devices to gather patient parameters and share them with a cloud platform where
they are processed to provide real-time feedback. The reported discussion highlights the structural
differences between the discussed frameworks, from the point of view of network configuration, data
management strategy, feedback modality, etc.Article Number: 1660openRoberto De Fazio; Massimo De Vittorio; Paolo ViscontiDE FAZIO, Roberto; DE VITTORIO, Massimo; Visconti, Paol
Design, characterization and validation of integrated bioelectronics for cellular studies: from inkjet-printed sensors to organic actuators
Mención Internacional en el título de doctorAdvances in bioinspired and biomimetic electronics have enabled
coupling engineering devices to biological systems with unprecedented
integration levels. Major efforts, however, have been devoted to interface
malleable electronic devices externally to the organs and tissues. A promising
alternative is embedding electronics into living tissues/organs or,
turning the concept inside out, lading electronic devices with soft living
matters which may accomplish remote monitoring and control of tissue’s
functions from within. This endeavor may unleash the ability to engineer
“living electronics” for regenerative medicine and biomedical applications.
In this context, it remains a challenge to insert electronic devices efficiently
with living cells in a way that there are minimal adverse reactions
in the biological host while the electronics maintaining the engineered
functionalities. In addition, investigating in real-time and with minimal
invasion the long-term responses of biological systems that are brought
in contact with such bioelectronic devices is desirable.
In this work we introduce the development (design, fabrication and
characterization) and validation of sensors and actuators mechanically
soft and compliant to cells able to properly operate embedded into a
cell culture environment, specifically of a cell line of human epithelial
keratinocytes. For the development of the sensors we propose moving from conventional microtechnology approaches to techniques compatible
with bioprinting in a way to support the eventual fabrication of tissues
and electronic sensors in a single hybrid plataform simultaneously. For
the actuators we explore the use of electroactive, organic, printing-compatible
polymers to induce cellular responses as a drug-free alternative
to the classic chemical route in a way to gain eventual control of biological
behaviors electronically. In particular, the presented work introduces
inkjet-printed interdigitated electrodes to monitor label-freely and
non-invasively cellular migration, proliferation and cell-sensor adhesions
of epidermal cells (HaCaT cells) using impedance spectroscopy and the
effects of (dynamic) mechanical stimulation on proliferation, migration
and morphology of keratinocytes by varying the magnitude, frequency
and duration of mechanical stimuli exploiting the developed biocompatible
actuator.
The results of this thesis contribute to the envision of three-dimensional
laboratory-growth tissues with built-in electronics, paving exciting
avenues towards the idea of living smart cyborg-skin substitutes.En los útimos años los avances en el desarrollo de dispositivos
electrónicos diseñados imitando las propiedades de sistemas vivos han
logrado acoplar sistemas electrónicos y órganos/tejidos biológicos con
un nivel de integración sin precedentes. Convencionalmente, la forma
en que estos sistemas bioelectrónicos son integrados con órganos o tejidos
ha sido a través del contacto superficial entre ambos sistemas, es
decir acoplando la electrónica externamente al tejido. Lamentablemente
estas aproximaciones no contemplan escenarios donde ha habido una
pérdida o daño del tejido con el cual interactuar, como es el caso de daños
en la piel debido a quemaduras, úlceras u otras lesiones genéticas
o producidas. Una alternativa prometedora para ingeniería de tejidos y
medicina regenerativa, y en particular para implantes de piel, es embeber
la electrónica dentro del tejido, o presentado de otra manera, cargar
el sistema electrónico con células vivas y tejidos fabricados por ingeniería
de tejidos como parte innata del propio dispositivo. Este concepto
permitiría no solo una monitorización remota y un control basado en
señalizaciones eléctricas (sin químicos) de tejidos biológicos fabricados
mediante técnicas de bioingeniería desde dentro del propio tejido, sino
también la fabricación de una “electrónica viva”, biológica y eléctricamente
funcional. En este contexto, es un desafío insertar de manera
eficiente dispositivos electrónicos con células vivas sin desencadenar
reacciones adversas en el sistema biológico receptor ni en el sistema
electrónico diseñado. Además, es deseable monitorizar en tiempo real
y de manera mínimamente invasiva las respuestas de dichos sistemas
biológicos que se han añadido a tales dispositivos bioelectrónicos.
En este trabajo presentamos el desarrollo (diseño, fabricación y caracterización)
y validación de sensores y actuadores mecánicamente suaves y
compatibles con células capaces de funcionar correctamente dentro de un
entorno de cultivo celular, específicamente de una línea celular de células epiteliales
humanas. Para el desarrollo de los sensores hemos propuesto utilizar
técnicas compatibles con la bioimpresión, alejándonos de la micro fabricación
tradicionalmente usada para la manufactura de sensores electrónicos, con el
objetivo a largo plazo de promover la fabricación de los tejidos y los sensores
electrónicos simultáneamente en un mismo sistema de impresión híbrido.
Para el desarrollo de los actuadores hemos explorado el uso de polímeros
electroactivos y compatibles con impresión y hemos investigado el efecto
de estímulos mecánicos dinámicos en respuestas celulares con el objetivo a
largo plazo de autoinducir comportamientos biológicos controlados de forma
electrónica. En concreto, este trabajo presenta sensores basados en electrodos
interdigitados impresos por inyección de tinta para monitorear la migración
celular, proliferación y adhesiones célula-sustrato de una línea celular de
células epiteliales humanas (HaCaT) en tiempo real y de manera no invasiva
mediante espectroscopía de impedancia. Por otro lado, este trabajo presenta
actuadores biocompatibles basados en el polímero piezoeléctrico fluoruro de
poli vinilideno y ha investigado los efectos de estimular mecánicamente células
epiteliales en relación con la proliferación, migración y morfología celular
mediante variaciones dinámicas de la magnitud, frecuencia y duración de
estímulos mecánicos explotando el actuador biocompatible propuesto.
Ambos sistemas presentados como resultado de esta tesis doctoral
contribuyen al desarrollo de tejidos 3D con electrónica incorporada,
promoviendo una investigación hacia la fabricación de sustitutos equivalentes
de piel mitad orgánica mitad electrónica como tejidos funcionales
biónicos inteligentes.The main works presented in this thesis have been
conducted in the facilities of the Universidad Carlos III
de Madrid with support from the program Formación del
Profesorado Universitario FPU015/06208 granted by Spanish Ministry
of Education, Culture and Sports. Some of the work has been also
developed in the facilities of the Fraunhofer-Institut für Zuverlässigkeit
und Mikrointegration (IZM) and University of Applied Sciences (HTW) in
Berlin, under the supervision of Prof. Dr. Ing. H-D. Ngo during a research
visit funded by the Mobility Fellows Program by the Spanish Ministry of
Education, Culture, and Sports.
This work has been developed in the framework of the projects
BIOPIELTEC-CM (P2018/BAA-4480), funded by Comunidad de Madrid,
and PARAQUA (TEC2017-86271-R) funded by Ministerio de Ciencia e
Innovación.Programa de Doctorado en Ingeniería Eléctrica, Electrónica y Automática por la Universidad Carlos III de MadridPresidente: José Antonio García Souto.- Secretario: Carlos Elvira Pujalte.- Vocal: María Dimak
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