NeuroSVM: A Graphical User Interface for Identification of Liver Patients

Diagnosis of liver infection at preliminary stage is important for better treatment. In todays scenario devices like sensors are used for detection of infections. Accurate classification techniques are required for automatic identification of disease samples. In this context, this study utilizes data mining approaches for classification of liver patients from healthy individuals. Four algorithms (Naive Bayes, Bagging, Random forest and SVM) were implemented for classification using R platform. Further to improve the accuracy of classification a hybrid NeuroSVM model was developed using SVM and feed-forward artificial neural network (ANN). The hybrid model was tested for its performance using statistical parameters like root mean square error (RMSE) and mean absolute percentage error (MAPE). The model resulted in a prediction accuracy of 98.83%. The results suggested that development of hybrid model improved the accuracy of prediction. To serve the medicinal community for prediction of liver disease among patients, a graphical user interface (GUI) has been developed using R. The GUI is deployed as a package in local repository of R platform for users to perform prediction.Comment: 9 pages, 6 figure

Machine Learning Algorithms Based Non Alcoholic Fatty Liver Disease Prediction

The early stage liver diseases prediction is an important health related research and using this kind of research easily can predict the diseases and take the remedies. The liver diseases are classified into different types such as liver cancer, liver tumor, fatty liver, hepatitis, cirrhosis etc. Non-Alcoholic Fatty Liver Disease is a kind of chronic disease which rigorous prediction is quite difficult at early stages. The prediction of fatty liver plays significant role in treating the disease and also constraining the next health consequences. This paper presents Machine Learning Algorithms based Non Alcoholic Fatty Liver Disease (NAFLD) prediction. The main objective of this project is to identify the potential factors causing NAFLD by using Machine Learning algorithms like Decision Tree (DT) classifier, Support Vector Machine (SVM) classifier, Random Forest (RF) classifier, Logistic regression (LR). Accuracy is used parameter for performance analysis evaluation. The findings of this paper show that random forest model accurately predicts a non-alcoholic fatty liver disease patient.Published By: Blue Eyes Intelligence Engineering and Sciences Publication (BEIESP) © Copyright: All rights reserved

Predicting and elucidating the etiology of fatty liver disease : A machine learning modeling and validation study in the IMI DIRECT cohorts

Background Non-alcoholic fatty liver disease (NAFLD) is highly prevalent and causes serious health complications in individuals with and without type 2 diabetes (T2D). Early diagnosis of NAFLD is important, as this can help prevent irreversible damage to the liver and, ultimately, hepatocellular carcinomas. We sought to expand etiological understanding and develop a diagnostic tool for NAFLD using machine learning. Methods and findings We utilized the baseline data from IMI DIRECT, a multicenter prospective cohort study of 3,029 European-ancestry adults recently diagnosed with T2D (n= 795) or at high risk of developing the disease (n= 2,234). Multi-omics (genetic, transcriptomic, proteomic, and metabolomic) and clinical (liver enzymes and other serological biomarkers, anthropometry, measures of beta-cell function, insulin sensitivity, and lifestyle) data comprised the key input variables. The models were trained on MRI-image-derived liver fat content (= 5%) available for 1,514 participants. We applied LASSO (least absolute shrinkage and selection operator) to select features from the different layers of omics data and random forest analysis to develop the models. The prediction models included clinical and omics variables separately or in combination. A model including all omics and clinical variables yielded a cross-validated receiver operating characteristic area under the curve (ROCAUC) of 0.84 (95% CI 0.82, 0.86;p = 5%) rather than a continuous one. Conclusions In this study, we developed several models with different combinations of clinical and omics data and identified biological features that appear to be associated with liver fat accumulation. In general, the clinical variables showed better prediction ability than the complex omics variables. However, the combination of omics and clinical variables yielded the highest accuracy. We have incorporated the developed clinical models into a web interface (see:) and made it available to the community.Peer reviewe

IMPROVING CORONARY HEART DISEASE PREDICTION BY OUTLIER ELIMINATION

Nowadays, heart disease is the major cause of deaths globally. According to a survey conducted by the World Health Organization, almost 18 million people die of heart diseases (or cardiovascular diseases) every day. So, there should be a system for early detection and prevention of heart disease. Detection of heart disease mostly depends on the huge pathological and clinical data that is quite complex. So, researchers and other medical professionals are showing keen interest in accurate prediction of heart disease.  Heart disease is a general term for a large number of medical conditions related to heart and one of them is the coronary heart disease (CHD). Coronary heart disease is caused by the amassing of plaque on the artery walls. In this paper, various machine learning base and ensemble classifiers have been applied on heart disease dataset for efficient prediction of coronary heart disease. Various machine learning classifiers that have been employed include k-nearest neighbor, multilayer perceptron, multinomial naïve bayes, logistic regression, decision tree, random forest and support vector machine classifiers. Ensemble classifiers that have been used include majority voting, weighted average, bagging and boosting classifiers. The dataset used in this study is obtained from the Framingham Heart Study which is a long-term, ongoing cardiovascular study of people from the Framingham city in Massachusetts, USA. To evaluate the performance of the classifiers, various evaluation metrics including accuracy, precision, recall and f1 score have been used. According to our results, the best accuracy was achieved by logistic regression, random forest, majority voting, weighted average and bagging classifiers but the highest accuracy among these was achieved using weighted average ensemble classifier.&nbsp

Automated Machine Learning (AutoML)-Derived Preconception Predictive Risk Model to Guide Early Intervention for Gestational Diabetes Mellitus

The increasing prevalence of gestational diabetes mellitus (GDM) is contributing to the rising global burden of type 2 diabetes (T2D) and intergenerational cycle of chronic metabolic disorders. Primary lifestyle interventions to manage GDM, including second trimester dietary and exercise guidance, have met with limited success due to late implementation, poor adherence and generic guidelines. In this study, we aimed to build a preconception-based GDM predictor to enable early intervention. We also assessed the associations of top predictors with GDM and adverse birth outcomes. Our evolutionary algorithm-based automated machine learning (AutoML) model was implemented with data from 222 Asian multi-ethnic women in a preconception cohort study, Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO). A stacked ensemble model with a gradient boosting classifier and linear support vector machine classifier (stochastic gradient descent training) was derived using genetic programming, achieving an excellent AUC of 0.93 based on four features (glycated hemoglobin A(1c) (HbA(1c)), mean arterial blood pressure, fasting insulin, triglycerides/HDL ratio). The results of multivariate logistic regression model showed that each 1 mmol/mol increase in preconception HbA(1c) was positively associated with increased risks of GDM (p = 0.001, odds ratio (95% CI) 1.34 (1.13-1.60)) and preterm birth (p = 0.011, odds ratio 1.63 (1.12-2.38)). Optimal control of preconception HbA(1c) may aid in preventing GDM and reducing the incidence of preterm birth. Our trained predictor has been deployed as a web application that can be easily employed in GDM intervention programs, prior to conception.Peer reviewe

Recent Advances in Machine Learning Applied to Ultrasound Imaging

Machine learning (ML) methods are pervading an increasing number of fields of application because of their capacity to effectively solve a wide variety of challenging problems. The employment of ML techniques in ultrasound imaging applications started several years ago but the scientific interest in this issue has increased exponentially in the last few years. The present work reviews the most recent (2019 onwards) implementations of machine learning techniques for two of the most popular ultrasound imaging fields, medical diagnostics and non-destructive evaluation. The former, which covers the major part of the review, was analyzed by classifying studies according to the human organ investigated and the methodology (e.g., detection, segmentation, and/or classification) adopted, while for the latter, some solutions to the detection/classification of material defects or particular patterns are reported. Finally, the main merits of machine learning that emerged from the study analysis are summarized and discussed. © 2022 by the authors. Licensee MDPI, Basel, Switzerland

Network of Interactions Between Gut Microbiome, Host Biomarkers, and Urine Metabolome in Carotid Atherosclerosis

Comprehensive analyses of multi-omics data may provide insights into interactions between different biological layers concerning distinct clinical features. We integrated data on the gut microbiota, blood parameters and urine metabolites of treatment-naive individuals presenting a wide range of metabolic disease phenotypes to delineate clinically meaningful associations. Trans-omics correlation networks revealed that candidate gut microbial biomarkers and urine metabolite feature were covaried with distinct clinical phenotypes. Integration of the gut microbiome, the urine metabolome and the phenome revealed that variations in one of these three systems correlated with changes in the other two. In a specific note about clinical parameters of liver function, we identified Eubacteriumeligens, Faecalibacteriumprausnitzii and Ruminococcuslactaris to be associated with a healthy liver function, whereas Clostridium bolteae, Tyzzerellanexills, Ruminococcusgnavus, Blautiahansenii, and Atopobiumparvulum were associated with blood biomarkers for liver diseases. Variations in these microbiota features paralleled changes in specific urine metabolites. Network modeling yielded two core clusters including one large gut microbe-urine metabolite close-knit cluster and one triangular cluster composed of a gut microbe-blood-urine network, demonstrating close inter-system crosstalk especially between the gut microbiome and the urine metabolome. Distinct clinical phenotypes are manifested in both the gut microbiome and the urine metabolome, and inter-domain connectivity takes the form of high-dimensional networks. Such networks may further our understanding of complex biological systems, and may provide a basis for identifying biomarkers for diseases. Deciphering the complexity of human physiology and disease requires a holistic and trans-omics approach integrating multi-layer data sets, including the gut microbiome and profiles of biological fluids. By studying the gut microbiome on carotid atherosclerosis, we identified microbial features associated with clinical parameters, and we observed that groups of urine metabolites correlated with groups of clinical parameters. Combining the three data sets, we revealed correlations of entities across the three systems, suggesting that physiological changes are reflected in each of the omics. Our findings provided insights into the interactive network between the gut microbiome, blood clinical parameters and the urine metabolome concerning physiological variations, and showed the promise of trans-omics study for biomarker discovery.publishedVersio