Certification of Bounds of Non-linear Functions: the Templates Method

The aim of this work is to certify lower bounds for real-valued multivariate functions, defined by semialgebraic or transcendental expressions. The certificate must be, eventually, formally provable in a proof system such as Coq. The application range for such a tool is widespread; for instance Hales' proof of Kepler's conjecture yields thousands of inequalities. We introduce an approximation algorithm, which combines ideas of the max-plus basis method (in optimal control) and of the linear templates method developed by Manna et al. (in static analysis). This algorithm consists in bounding some of the constituents of the function by suprema of quadratic forms with a well chosen curvature. This leads to semialgebraic optimization problems, solved by sum-of-squares relaxations. Templates limit the blow up of these relaxations at the price of coarsening the approximation. We illustrate the efficiency of our framework with various examples from the literature and discuss the interfacing with Coq.Comment: 16 pages, 3 figures, 2 table

Towards a better approximation for sparsest cut?

We give a new $(1+\epsilon)$-approximation for sparsest cut problem on graphs where small sets expand significantly more than the sparsest cut (sets of size $n/r$ expand by a factor $\sqrt{\log n\log r}$ bigger, for some small $r$; this condition holds for many natural graph families). We give two different algorithms. One involves Guruswami-Sinop rounding on the level-$r$ Lasserre relaxation. The other is combinatorial and involves a new notion called {\em Small Set Expander Flows} (inspired by the {\em expander flows} of ARV) which we show exists in the input graph. Both algorithms run in time $2^{O(r)} \mathrm{poly}(n)$. We also show similar approximation algorithms in graphs with genus $g$ with an analogous local expansion condition. This is the first algorithm we know of that achieves $(1+\epsilon)$-approximation on such general family of graphs

A New Regularity Lemma and Faster Approximation Algorithms for Low Threshold Rank Graphs

Kolla and Tulsiani [KT07,Kolla11} and Arora, Barak and Steurer [ABS10] introduced the technique of subspace enumeration, which gives approximation algorithms for graph problems such as unique games and small set expansion; the running time of such algorithms is exponential in the threshold-rank of the graph. Guruswami and Sinop [GS11,GS12], and Barak, Raghavendra, and Steurer [BRS11] developed an alternative approach to the design of approximation algorithms for graphs of bounded threshold-rank, based on semidefinite programming relaxations in the Lassere hierarchy and on novel rounding techniques. These algorithms are faster than the ones based on subspace enumeration and work on a broad class of problems. In this paper we develop a third approach to the design of such algorithms. We show, constructively, that graphs of bounded threshold-rank satisfy a weak Szemeredi regularity lemma analogous to the one proved by Frieze and Kannan [FK99] for dense graphs. The existence of efficient approximation algorithms is then a consequence of the regularity lemma, as shown by Frieze and Kannan. Applying our method to the Max Cut problem, we devise an algorithm that is faster than all previous algorithms, and is easier to describe and analyze

Mixed-integer Nonlinear Optimization: a hatchery for modern mathematics

The second MFO Oberwolfach Workshop on Mixed-Integer Nonlinear Programming (MINLP) took place between 2nd and 8th June 2019. MINLP refers to one of the hardest Mathematical Programming (MP) problem classes, involving both nonlinear functions as well as continuous and integer decision variables. MP is a formal language for describing optimization problems, and is traditionally part of Operations Research (OR), which is itself at the intersection of mathematics, computer science, engineering and econometrics. The scientific program has covered the three announced areas (hierarchies of approximation, mixed-integer nonlinear optimal control, and dealing with uncertainties) with a variety of tutorials, talks, short research announcements, and a special "open problems'' session

Scalable computation of intracellular metabolite concentrations

Current mathematical frameworks for predicting the flux state and macromolecular composition of the cell do not rely on thermodynamic constraints to determine the spontaneous direction of reactions. These predictions may be biologically infeasible as a result. Imposing thermodynamic constraints requires accurate estimations of intracellular metabolite concentrations. These concentrations are constrained within physiologically possible ranges to enable an organism to grow in extreme conditions and adapt to its environment. Here, we introduce tractable computational techniques to characterize intracellular metabolite concentrations within a constraint-based modeling framework. This model provides a feasible concentration set, which can generally be nonconvex and disconnected. We examine three approaches based on polynomial optimization, random sampling, and global optimization. We leverage the sparsity and algebraic structure of the underlying biophysical models to enhance the computational efficiency of these techniques. We then compare their performance in two case studies, showing that the global-optimization formulation exhibits more desirable scaling properties than the random-sampling and polynomial-optimization formulation, and, thus, is a promising candidate for handling large-scale metabolic networks