Human metabolic adaptations and prolonged expensive neurodevelopment: A review

1.	After weaning, human hunter-gatherer juveniles receive substantial (≈3.5-7 MJ day^-1^), extended (≈15 years) and reliable (kin and nonkin food pooling) energy provision.
2.	The childhood (pediatric) and the adult human brain takes a very high share of both basal metabolic rate (BMR) (child: 50-70%; adult: ≈20%) and total energy expenditure (TEE) (child: 30-50%; adult: ≈10%).
3.	The pediatric brain for an extended period (≈4-9 years-of-age) consumes roughly 50% more energy than the adult one, and after this, continues during adolescence, at a high but declining rate. Within the brain, childhood cerebral gray matter has an even higher 1.9 to 2.2-fold increased energy consumption. 
4.	This metabolic expensiveness is due to (i) the high cost of synapse activation (74% of brain energy expenditure in humans), combined with (ii), a prolonged period of exuberance in synapse numbers (up to double the number present in adults). Cognitive development during this period associates with volumetric changes in gray matter (expansion and contraction due to metabolic related size alterations in glial cells and capillary vascularization), and in white matter (expansion due to myelination). 
5.	Amongst mammals, anatomically modern humans show an unique pattern in which very slow musculoskeletal body growth is followed by a marked adolescent size/stature spurt. This pattern of growth contrasts with nonhuman primates that have a sustained fast juvenile growth with only a minor period of puberty acceleration. The existence of slow childhood growth in humans has been shown to date back to 160,000 BP. 
6.	Human children physiologically have a limited capacity to protect the brain from plasma glucose fluctuations and other metabolic disruptions. These can arise in adults, during prolonged strenuous exercise when skeletal muscle depletes plasma glucose, and produces other metabolic disruptions upon the brain (hypoxia, hyperthermia, dehydration and hyperammonemia). These are proportional to muscle mass.
7.	Children show specific adaptations to minimize such metabolic disturbances. (i) Due to slow body growth and resulting small body size, they have limited skeletal muscle mass. (ii) They show other adaptations such as an exercise specific preference for free fatty acid metabolism. (iii) While children are generally more active than adolescents and adults, they avoid physically prolonged intense exertion. 
8.	Childhood has a close relationship to high levels of energy provision and metabolic adaptations that support prolonged synaptic neurodevelopment. 
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Characterizing slope instability kinematics by integrating multi-sensor satellite remote sensing observations

Over the past few decades, the occurrence and intensity of geological hazards, such as landslides, have substantially risen due to various factors, including global climate change, seismic events, rapid urbanization and other anthropogenic activities. Landslide disasters pose a significant risk in both urban and rural areas, resulting in fatalities, infrastructure damages, and economic losses. Nevertheless, conventional ground-based monitoring techniques are often costly, time-consuming, and require considerable resources. Moreover, some landslide incidents occur in remote or hazardous locations, making ground-based observation and field investigation challenging or even impossible. Fortunately, the advancements in spaceborne remote sensing technology have led to the availability of large-scale and high-quality imagery, which can be utilized for various landslide-related applications, including identification, monitoring, analysis, and prediction. This efficient and cost-effective technology allows for remote monitoring and assessment of landslide risks and can significantly contribute to disaster management and mitigation efforts. Consequently, spaceborne remote sensing techniques have become vital for geohazard management in many countries, benefiting society by providing reliable downstream services. However, substantial effort is required to ensure that such benefits are provided. For establishing long-term data archives and reliable analyses, it is essential to maintain consistent and continued use of multi-sensor spaceborne remote sensing techniques. This will enable a more thorough understanding of the physical mechanisms responsible for slope instabilities, leading to better decision-making and development of effective mitigation strategies. Ultimately, this can reduce the impact of landslide hazards on the general public. The present dissertation contributes to this effort from the following perspectives: 1. To obtain a comprehensive understanding of spaceborne remote sensing techniques for landslide monitoring, we integrated multi-sensor methods to monitor the entire life cycle of landslide dynamics. We aimed to comprehend the landslide evolution under complex cascading events by utilizing various spaceborne remote sensing techniques, e.g., the precursory deformation before catastrophic failure, co-failure procedures, and post-failure evolution of slope instability. 2. To address the discrepancies between spaceborne optical and radar imagery, we present a methodology that models four-dimensional (4D) post-failure landslide kinematics using a decaying mathematical model. This approach enables us to represent the stress relaxation for the landslide body dynamics after failure. By employing this methodology, we can overcome the weaknesses of the individual sensor in spaceborne optical and radar imaging. 3. We assessed the effectiveness of a newly designed small dihedral corner reflector for landslide monitoring. The reflector is compatible with both ascending and descending satellite orbits, while it is also suitable for applications with both high-resolution and medium-resolution satellite imagery. Furthermore, although its echoes are not as strong as those of conventional reflectors, the cost of the newly designed reflectors is reduced, with more manageable installation and maintenance. To overcome this limitation, we propose a specific selection strategy based on a probability model to identify the reflectors in satellite images

8th Annual Jackson School of Geosciences Student Research Symposium, February 2, 2019

ConocoPhillipsGeological Science