19,885 research outputs found
Indexing large genome collections on a PC
Motivation: The availability of thousands of invidual genomes of one species
should boost rapid progress in personalized medicine or understanding of the
interaction between genotype and phenotype, to name a few applications. A key
operation useful in such analyses is aligning sequencing reads against a
collection of genomes, which is costly with the use of existing algorithms due
to their large memory requirements.
Results: We present MuGI, Multiple Genome Index, which reports all
occurrences of a given pattern, in exact and approximate matching model,
against a collection of thousand(s) genomes. Its unique feature is the small
index size fitting in a standard computer with 16--32\,GB, or even 8\,GB, of
RAM, for the 1000GP collection of 1092 diploid human genomes. The solution is
also fast. For example, the exact matching queries are handled in average time
of 39\,s and with up to 3 mismatches in 373\,s on the test PC with
the index size of 13.4\,GB. For a smaller index, occupying 7.4\,GB in memory,
the respective times grow to 76\,s and 917\,s.
Availability: Software and Suuplementary material:
\url{http://sun.aei.polsl.pl/mugi}
String Indexing for Patterns with Wildcards
We consider the problem of indexing a string of length to report the
occurrences of a query pattern containing characters and wildcards.
Let be the number of occurrences of in , and the size of
the alphabet. We obtain the following results.
- A linear space index with query time .
This significantly improves the previously best known linear space index by Lam
et al. [ISAAC 2007], which requires query time in the worst case.
- An index with query time using space , where is the maximum number of wildcards allowed in the pattern.
This is the first non-trivial bound with this query time.
- A time-space trade-off, generalizing the index by Cole et al. [STOC 2004].
We also show that these indexes can be generalized to allow variable length
gaps in the pattern. Our results are obtained using a novel combination of
well-known and new techniques, which could be of independent interest
Improved Approximate String Matching and Regular Expression Matching on Ziv-Lempel Compressed Texts
We study the approximate string matching and regular expression matching
problem for the case when the text to be searched is compressed with the
Ziv-Lempel adaptive dictionary compression schemes. We present a time-space
trade-off that leads to algorithms improving the previously known complexities
for both problems. In particular, we significantly improve the space bounds,
which in practical applications are likely to be a bottleneck
Indexing, browsing and searching of digital video
Video is a communications medium that normally brings together moving pictures with a synchronised audio track into a discrete piece or pieces of information. The size of a âpiece â of video can variously be referred to as a frame, a shot, a scene, a clip, a programme or an episode, and these are distinguished by their lengths and by their composition. We shall return to the definition of each of these in section 4 this chapter. In modern society, video is ver
Dynamic Relative Compression, Dynamic Partial Sums, and Substring Concatenation
Given a static reference string and a source string , a relative
compression of with respect to is an encoding of as a sequence of
references to substrings of . Relative compression schemes are a classic
model of compression and have recently proved very successful for compressing
highly-repetitive massive data sets such as genomes and web-data. We initiate
the study of relative compression in a dynamic setting where the compressed
source string is subject to edit operations. The goal is to maintain the
compressed representation compactly, while supporting edits and allowing
efficient random access to the (uncompressed) source string. We present new
data structures that achieve optimal time for updates and queries while using
space linear in the size of the optimal relative compression, for nearly all
combinations of parameters. We also present solutions for restricted and
extended sets of updates. To achieve these results, we revisit the dynamic
partial sums problem and the substring concatenation problem. We present new
optimal or near optimal bounds for these problems. Plugging in our new results
we also immediately obtain new bounds for the string indexing for patterns with
wildcards problem and the dynamic text and static pattern matching problem
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