8,990 research outputs found
An Unsupervised Learning Model for Deformable Medical Image Registration
We present a fast learning-based algorithm for deformable, pairwise 3D
medical image registration. Current registration methods optimize an objective
function independently for each pair of images, which can be time-consuming for
large data. We define registration as a parametric function, and optimize its
parameters given a set of images from a collection of interest. Given a new
pair of scans, we can quickly compute a registration field by directly
evaluating the function using the learned parameters. We model this function
using a convolutional neural network (CNN), and use a spatial transform layer
to reconstruct one image from another while imposing smoothness constraints on
the registration field. The proposed method does not require supervised
information such as ground truth registration fields or anatomical landmarks.
We demonstrate registration accuracy comparable to state-of-the-art 3D image
registration, while operating orders of magnitude faster in practice. Our
method promises to significantly speed up medical image analysis and processing
pipelines, while facilitating novel directions in learning-based registration
and its applications. Our code is available at
https://github.com/balakg/voxelmorph .Comment: 9 pages, in CVPR 201
A fast and robust patient specific Finite Element mesh registration technique: application to 60 clinical cases
Finite Element mesh generation remains an important issue for patient
specific biomechanical modeling. While some techniques make automatic mesh
generation possible, in most cases, manual mesh generation is preferred for
better control over the sub-domain representation, element type, layout and
refinement that it provides. Yet, this option is time consuming and not suited
for intraoperative situations where model generation and computation time is
critical. To overcome this problem we propose a fast and automatic mesh
generation technique based on the elastic registration of a generic mesh to the
specific target organ in conjunction with element regularity and quality
correction. This Mesh-Match-and-Repair (MMRep) approach combines control over
the mesh structure along with fast and robust meshing capabilities, even in
situations where only partial organ geometry is available. The technique was
successfully tested on a database of 5 pre-operatively acquired complete femora
CT scans, 5 femoral heads partially digitized at intraoperative stage, and 50
CT volumes of patients' heads. The MMRep algorithm succeeded in all 60 cases,
yielding for each patient a hex-dominant, Atlas based, Finite Element mesh with
submillimetric surface representation accuracy, directly exploitable within a
commercial FE software
Prostate Biopsy Assistance System with Gland Deformation Estimation for Enhanced Precision
Computer-assisted prostate biopsies became a very active research area during
the last years. Prostate tracking makes it possi- ble to overcome several
drawbacks of the current standard transrectal ultrasound (TRUS) biopsy
procedure, namely the insufficient targeting accuracy which may lead to a
biopsy distribution of poor quality, the very approximate knowledge about the
actual location of the sampled tissues which makes it difficult to implement
focal therapy strategies based on biopsy results, and finally the difficulty to
precisely reach non-ultrasound (US) targets stemming from different modalities,
statistical atlases or previous biopsy series. The prostate tracking systems
presented so far are limited to rigid transformation tracking. However, the
gland can get considerably deformed during the intervention because of US probe
pres- sure and patient movements. We propose to use 3D US combined with
image-based elastic registration to estimate these deformations. A fast elastic
registration algorithm that copes with the frequently occurring US shadows is
presented. A patient cohort study was performed, which yielded a statistically
significant in-vivo accuracy of 0.83+-0.54mm.Comment: This version of the paper integrates a correction concerning the
local similarity measure w.r.t. the proceedings (this typing error could not
be corrected before editing the proceedings
A novel variational model for image registration using Gaussian curvature
Image registration is one important task in many image processing
applications. It aims to align two or more images so that useful information
can be extracted through comparison, combination or superposition. This is
achieved by constructing an optimal trans- formation which ensures that the
template image becomes similar to a given reference image. Although many models
exist, designing a model capable of modelling large and smooth deformation
field continues to pose a challenge. This paper proposes a novel variational
model for image registration using the Gaussian curvature as a regulariser. The
model is motivated by the surface restoration work in geometric processing
[Elsey and Esedoglu, Multiscale Model. Simul., (2009), pp. 1549-1573]. An
effective numerical solver is provided for the model using an augmented
Lagrangian method. Numerical experiments can show that the new model
outperforms three competing models based on, respectively, a linear curvature
[Fischer and Modersitzki, J. Math. Imaging Vis., (2003), pp. 81- 85], the mean
curvature [Chumchob, Chen and Brito, Multiscale Model. Simul., (2011), pp.
89-128] and the diffeomorphic demon model [Vercauteren at al., NeuroImage,
(2009), pp. 61-72] in terms of robustness and accuracy.Comment: 23 pages, 5 figures. Key words: Image registration, Non-parametric
image registration, Regularisation, Gaussian curvature, surface mappin
Framework for a low-cost intra-operative image-guided neuronavigator including brain shift compensation
In this paper we present a methodology to address the problem of brain tissue
deformation referred to as 'brain-shift'. This deformation occurs throughout a
neurosurgery intervention and strongly alters the accuracy of the
neuronavigation systems used to date in clinical routine which rely solely on
pre-operative patient imaging to locate the surgical target, such as a tumour
or a functional area. After a general description of the framework of our
intra-operative image-guided system, we describe a procedure to generate
patient specific finite element meshes of the brain and propose a biomechanical
model which can take into account tissue deformations and surgical procedures
that modify the brain structure, like tumour or tissue resection
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