Enhancing Upper Limb Prostheses Through Neuromorphic Sensory Feedback

Upper limb prostheses are rapidly improving in terms of both control and sensory feedback, giving rise to lifelike robotic devices that aim to restore function to amputees. Recent progress in forward control has enabled prosthesis users to make complicated grip patterns with a prosthetic hand and nerve stimulation has enabled sensations of touch in the missing hand of an amputee. A brief overview of the motivation behind the work in this thesis is given in Chapter 1, which is followed by a general overview of the field and state of the art research (Chapter 2). Chapters 3 and 4 look at the use of closed loop tactile feedback for improving prosthesis grasping functionality. This entails development of two algorithms for improving object manipulation (Chapter 3) and the first real-time implementation of neuromorphic tactile signals being used as feedback to a prosthesis controller for improved grasping (Chapter 4). The second half of the thesis (Chatpers 5 - 7) details how sensory information can be conveyed back to an amputee and how the tactile sensations can be utilized for creating a more lifelike prosthesis. Noninvasive electrical nerve stimulation was shown to provide sensations in multiple regions of the phantom hand of amputees both with and without targeted sensory reinnervation surgery (Chapter 5). A multilayered electronic dermis (e-dermis) was developed to mimic the behavior of receptors in the skin to provide, for the first time, sensations of both touch and pain back to an amputee and the prosthesis (Chapter 6). Finally, the first demonstration of sensory feedback as a key component of phantom hand movement for myoelectric pattern recognition shows that enhanced perceptions of the phantom hand can lead to improved prosthesis control (Chapter 7). This work provides the first demonstration of how amputees can perceive multiple tactile sensations through a neuromorphic stimulation paradigm. Furthermore, it describes the unique role that nerve stimulation and phantom hand activation play in the sensorimotor loop of upper limb amputees

Event-Driven Technologies for Reactive Motion Planning: Neuromorphic Stereo Vision and Robot Path Planning and Their Application on Parallel Hardware

Die Robotik wird immer mehr zu einem Schlüsselfaktor des technischen Aufschwungs. Trotz beeindruckender Fortschritte in den letzten Jahrzehnten, übertreffen Gehirne von Säugetieren in den Bereichen Sehen und Bewegungsplanung noch immer selbst die leistungsfähigsten Maschinen. Industrieroboter sind sehr schnell und präzise, aber ihre Planungsalgorithmen sind in hochdynamischen Umgebungen, wie sie für die Mensch-Roboter-Kollaboration (MRK) erforderlich sind, nicht leistungsfähig genug. Ohne schnelle und adaptive Bewegungsplanung kann sichere MRK nicht garantiert werden. Neuromorphe Technologien, einschließlich visueller Sensoren und Hardware-Chips, arbeiten asynchron und verarbeiten so raum-zeitliche Informationen sehr effizient. Insbesondere ereignisbasierte visuelle Sensoren sind konventionellen, synchronen Kameras bei vielen Anwendungen bereits überlegen. Daher haben ereignisbasierte Methoden ein großes Potenzial, schnellere und energieeffizientere Algorithmen zur Bewegungssteuerung in der MRK zu ermöglichen. In dieser Arbeit wird ein Ansatz zur flexiblen reaktiven Bewegungssteuerung eines Roboterarms vorgestellt. Dabei wird die Exterozeption durch ereignisbasiertes Stereosehen erreicht und die Pfadplanung ist in einer neuronalen Repräsentation des Konfigurationsraums implementiert. Die Multiview-3D-Rekonstruktion wird durch eine qualitative Analyse in Simulation evaluiert und auf ein Stereo-System ereignisbasierter Kameras übertragen. Zur Evaluierung der reaktiven kollisionsfreien Online-Planung wird ein Demonstrator mit einem industriellen Roboter genutzt. Dieser wird auch für eine vergleichende Studie zu sample-basierten Planern verwendet. Ergänzt wird dies durch einen Benchmark von parallelen Hardwarelösungen wozu als Testszenario Bahnplanung in der Robotik gewählt wurde. Die Ergebnisse zeigen, dass die vorgeschlagenen neuronalen Lösungen einen effektiven Weg zur Realisierung einer Robotersteuerung für dynamische Szenarien darstellen. Diese Arbeit schafft eine Grundlage für neuronale Lösungen bei adaptiven Fertigungsprozesse, auch in Zusammenarbeit mit dem Menschen, ohne Einbußen bei Geschwindigkeit und Sicherheit. Damit ebnet sie den Weg für die Integration von dem Gehirn nachempfundener Hardware und Algorithmen in die Industrierobotik und MRK

Real-time Neuromorphic Visual Pre-Processing and Dynamic Saliency

The human brain is by far the most computationally complex, efficient, and reliable computing system operating under such low-power, small-size, and light-weight specifications. Within the field of neuromorphic engineering, we seek to design systems with facsimiles to that of the human brain with means to reach its desirable properties. In this doctoral work, the focus is within the realm of vision, specifically visual saliency and related visual tasks with bio-inspired, real-time processing. The human visual system, from the retina through the visual cortical hierarchy, is responsible for extracting visual information and processing this information, forming our visual perception. This visual information is transmitted through these various layers of the visual system via spikes (or action potentials), representing information in the temporal domain. The objective is to exploit this neurological communication protocol and functionality within the systems we design. This approach is essential for the advancement of autonomous, mobile agents (i.e. drones/MAVs, cars) which must perform visual tasks under size and power constraints in which traditional CPU or GPU implementations to not suffice. Although the high-level objective is to design a complete visual processor with direct physical and functional correlates to the human visual system, we focus on three specific tasks. The first focus of this thesis is the integration of motion into a biologically-plausible proto-object-based visual saliency model. Laurent Itti, one of the pioneers in the field, defines visual saliency as ``the distinct subjective perceptual quality which makes some items in the world stand out from their neighbors and immediately grab our attention.'' From humans to insects, visual saliency is important for the extraction of only interesting regions of visual stimuli for further processing. Prior to this doctoral work, Russel et al. \cite{russell2014model} designed a model of proto-object-based visual saliency with biological correlates. This model was designed for computing saliency only on static images. However, motion is a naturally occurring phenomena that plays an essential role in both human and animal visual processing. Henceforth, the most ideal model of visual saliency should consider motion that may be exhibited within the visual scene. In this work a novel dynamic proto-object-based visual saliency is described which extends the Russel et. al. saliency model to consider not only static, but also temporal information. This model was validated by using metrics for determining how accurate the model is in predicting human eye fixations and saccades on a public dataset of videos with attached eye tracking data. This model outperformed other state-of-the-art visual saliency models in computing dynamic visual saliency. Such a model that can accurately predict where humans look, can serve as a front-end component to other visual processors performing tasks such as object detection and recognition, or object tracking. In doing so it can reduce throughput and increase processing speed for such tasks. Furthermore, it has more obvious applications in artificial intelligence in mimicking the functionality of the human visual system. The second focus of this thesis is the implementation of this visual saliency model on an FPGA (Field Programmable Gate Array) for real-time processing. Initially, this model was designed within MATLAB, a software-based approach running on a CPU, which limits the processing speed and consumes unnecessary amounts of power due to overhead. This is detrimental for integration with an autonomous, mobile system which must operate in real-time. This novel FPGA implementation allows for a low-power, high-speed approach to computing visual saliency. There are a few existing FPGA-based implementations of visual saliency, and of those, none are based on the notion of proto-objects. This work presents the first, to our knowledge, FPGA implementation of an object-based visual saliency model. Such an FPGA implementation allows for the low-power, light-weight, and small-size specifications that we seek within the field of neuromorphic engineering. For validating the FPGA model, the same metrics are used for determining the extent to which it predicts human eye saccades and fixations. We compare this hardware implementation to the software model for validation. The third focus of this thesis is the design of a generic neuromorphic platform both on FPGA and VLSI (Very-Large-Scale-Integration) technology for performing visual tasks, including those necessary in the computation of the visual saliency. Visual processing tasks such as image filtering and image dewarping are demonstrated via this novel neuromorphic technology consisting of an array of hardware-based generalized integrate-and-fire neurons. It allows the visual saliency model's computation to be offloaded onto this hardware-based architecture. We first demonstrate an emulation of this neuromorphic system on FPGA demonstrating its capability of dewarping and filtering tasks as well as integration with a neuromorphic camera called the ATIS (Asynchronous Time-based Image Sensor). We then demonstrate the neuromorphic platform implemented in CMOS technology, specifically designed for low-mismatch, high-density, and low-power. Such a VLSI technology-based platform further bridges the gap between engineering and biology and moves us closer towards developing a complete neuromorphic visual processor

Enabling rapid iterative model design within the laboratory environment

This thesis presents a proof of concept study for the better integration of the electrophysiological and modelling aspects of neuroscience. Members of these two sub-disciplines collaborate regularly, but due to differing resource requirements, and largely incompatible spheres of knowledge, cooperation is often impeded by miscommunication and delays. To reduce the model design time, and provide a platform for more efficient experimental analysis, a rapid iterative model design method is proposed. The main achievement of this work is the development of a rapid model evaluation method based on parameter estimation, utilising a combination of evolutionary algorithms (EAs) and graphics processing unit (GPU) hardware acceleration. This method is the primary force behind the better integration of modelling and laboratorybased electrophysiology, as it provides a generic model evaluation method that does not require prior knowledge of model structure, or expertise in modelling, mathematics, or computer science. If combined with a suitable intuitive and user targeted graphical user interface, the ideas presented in this thesis could be developed into a suite of tools that would enable new forms of experimentation to be performed. The latter part of this thesis investigates the use of excitability-based models as the basis of an iterative design method. They were found to be computationally and structurally simple, easily extensible, and able to reproduce a wide range of neural behaviours whilst still faithfully representing underlying cellular mechanisms. A case study was performed to assess the iterative design process, through the implementation of an excitability-based model. The model was extended iteratively, using the rapid model evaluation method, to represent a vasopressin releasing neuron. Not only was the model implemented successfully, but it was able to suggest the existence of other more subtle cell mechanisms, in addition to highlighting potential failings in previous implementations of the class of neuron

A Practical Hardware Implementation of Systemic Computation

It is widely accepted that natural computation, such as brain computation, is far superior to typical computational approaches addressing tasks such as learning and parallel processing. As conventional silicon-based technologies are about to reach their physical limits, researchers have drawn inspiration from nature to found new computational paradigms. Such a newly-conceived paradigm is Systemic Computation (SC). SC is a bio-inspired model of computation. It incorporates natural characteristics and defines a massively parallel non-von Neumann computer architecture that can model natural systems efficiently. This thesis investigates the viability and utility of a Systemic Computation hardware implementation, since prior software-based approaches have proved inadequate in terms of performance and flexibility. This is achieved by addressing three main research challenges regarding the level of support for the natural properties of SC, the design of its implied architecture and methods to make the implementation practical and efficient. Various hardware-based approaches to Natural Computation are reviewed and their compatibility and suitability, with respect to the SC paradigm, is investigated. FPGAs are identified as the most appropriate implementation platform through critical evaluation and the first prototype Hardware Architecture of Systemic computation (HAoS) is presented. HAoS is a novel custom digital design, which takes advantage of the inbuilt parallelism of an FPGA and the highly efficient matching capability of a Ternary Content Addressable Memory. It provides basic processing capabilities in order to minimize time-demanding data transfers, while the optional use of a CPU provides high-level processing support. It is optimized and extended to a practical hardware platform accompanied by a software framework to provide an efficient SC programming solution. The suggested platform is evaluated using three bio-inspired models and analysis shows that it satisfies the research challenges and provides an effective solution in terms of efficiency versus flexibility trade-off

A Practical Investigation into Achieving Bio-Plausibility in Evo-Devo Neural Microcircuits Feasible in an FPGA

Many researchers has conjectured, argued, or in some cases demonstrated, that bio-plausibility can bring about emergent properties such as adaptability, scalability, fault-tolerance, self-repair, reliability, and autonomy to bio-inspired intelligent systems. Evolutionary-developmental (evo-devo) spiking neural networks are a very bio-plausible mixture of such bio-inspired intelligent systems that have been proposed and studied by a few researchers. However, the general trend is that the complexity and thus the computational cost grow with the bio-plausibility of the system. FPGAs (Field- Programmable Gate Arrays) have been used and proved to be one of the flexible and cost efficient hardware platforms for research' and development of such evo-devo systems. However, mapping a bio-plausible evo-devo spiking neural network to an FPGA is a daunting task full of different constraints and trade-offs that makes it, if not infeasible, very challenging. This thesis explores the challenges, trade-offs, constraints, practical issues, and some possible approaches in achieving bio-plausibility in creating evolutionary developmental spiking neural microcircuits in an FPGA through a practical investigation along with a series of case studies. In this study, the system performance, cost, reliability, scalability, availability, and design and testing time and complexity are defined as measures for feasibility of a system and structural accuracy and consistency with the current knowledge in biology as measures for bio-plausibility. Investigation of the challenges starts with the hardware platform selection and then neuron, cortex, and evo-devo models and integration of these models into a whole bio-inspired intelligent system are examined one by one. For further practical investigation, a new PLAQIF Digital Neuron model, a novel Cortex model, and a new multicellular LGRN evo-devo model are designed, implemented and tested as case studies. Results and their implications for the researchers, designers of such systems, and FPGA manufacturers are discussed and concluded in form of general trends, trade-offs, suggestions, and recommendations

Dynamical Systems in Spiking Neuromorphic Hardware

Dynamical systems are universal computers. They can perceive stimuli, remember, learn from feedback, plan sequences of actions, and coordinate complex behavioural responses. The Neural Engineering Framework (NEF) provides a general recipe to formulate models of such systems as coupled sets of nonlinear differential equations and compile them onto recurrently connected spiking neural networks – akin to a programming language for spiking models of computation. The Nengo software ecosystem supports the NEF and compiles such models onto neuromorphic hardware. In this thesis, we analyze the theory driving the success of the NEF, and expose several core principles underpinning its correctness, scalability, completeness, robustness, and extensibility. We also derive novel theoretical extensions to the framework that enable it to far more effectively leverage a wide variety of dynamics in digital hardware, and to exploit the device-level physics in analog hardware. At the same time, we propose a novel set of spiking algorithms that recruit an optimal nonlinear encoding of time, which we call the Delay Network (DN). Backpropagation across stacked layers of DNs dramatically outperforms stacked Long Short-Term Memory (LSTM) networks—a state-of-the-art deep recurrent architecture—in accuracy and training time, on a continuous-time memory task, and a chaotic time-series prediction benchmark. The basic component of this network is shown to function on state-of-the-art spiking neuromorphic hardware including Braindrop and Loihi. This implementation approaches the energy-efficiency of the human brain in the former case, and the precision of conventional computation in the latter case