18,503 research outputs found
Dynamic Construction of Stimulus Values in the Ventromedial Prefrontal Cortex
Signals representing the value assigned to stimuli at the time of choice have been repeatedly observed in ventromedial prefrontal cortex (vmPFC). Yet it remains unknown how these value representations are computed from sensory and memory representations in more posterior brain regions. We used electroencephalography (EEG) while subjects evaluated appetitive and aversive food items to study how event-related responses modulated by stimulus value evolve over time. We found that value-related activity shifted from posterior to anterior, and from parietal to central to frontal sensors, across three major time windows after stimulus onset: 150–250 ms, 400–550 ms, and 700–800 ms. Exploratory localization of the EEG signal revealed a shifting network of activity moving from sensory and memory structures to areas associated with value coding, with stimulus value activity localized to vmPFC only from 400 ms onwards. Consistent with these results, functional connectivity analyses also showed a causal flow of information from temporal cortex to vmPFC. Thus, although value signals are present as early as 150 ms after stimulus onset, the value signals in vmPFC appear relatively late in the choice process, and seem to reflect the integration of incoming information from sensory and memory related regions
Principles for the post-GWAS functional characterisation of risk loci
Several challenges lie ahead in assigning functionality to susceptibility SNPs. For example, most effect sizes are small relative to effects seen in monogenic diseases, with per allele odds ratios usually ranging from 1.15 to 1.3. It is unclear whether current molecular biology methods have enough resolution to differentiate such small effects. Our objective here is therefore to provide a set of recommendations to optimize the allocation of effort and resources in order maximize the chances of elucidating the functional contribution of specific loci to the disease phenotype. It has been estimated that 88% of currently identified disease-associated SNP are intronic or intergenic. Thus, in this paper we will focus our attention on the analysis of non-coding variants and outline a hierarchical approach for post-GWAS functional studies
Distinguishing cause from effect using observational data: methods and benchmarks
The discovery of causal relationships from purely observational data is a
fundamental problem in science. The most elementary form of such a causal
discovery problem is to decide whether X causes Y or, alternatively, Y causes
X, given joint observations of two variables X, Y. An example is to decide
whether altitude causes temperature, or vice versa, given only joint
measurements of both variables. Even under the simplifying assumptions of no
confounding, no feedback loops, and no selection bias, such bivariate causal
discovery problems are challenging. Nevertheless, several approaches for
addressing those problems have been proposed in recent years. We review two
families of such methods: Additive Noise Methods (ANM) and Information
Geometric Causal Inference (IGCI). We present the benchmark CauseEffectPairs
that consists of data for 100 different cause-effect pairs selected from 37
datasets from various domains (e.g., meteorology, biology, medicine,
engineering, economy, etc.) and motivate our decisions regarding the "ground
truth" causal directions of all pairs. We evaluate the performance of several
bivariate causal discovery methods on these real-world benchmark data and in
addition on artificially simulated data. Our empirical results on real-world
data indicate that certain methods are indeed able to distinguish cause from
effect using only purely observational data, although more benchmark data would
be needed to obtain statistically significant conclusions. One of the best
performing methods overall is the additive-noise method originally proposed by
Hoyer et al. (2009), which obtains an accuracy of 63+-10 % and an AUC of
0.74+-0.05 on the real-world benchmark. As the main theoretical contribution of
this work we prove the consistency of that method.Comment: 101 pages, second revision submitted to Journal of Machine Learning
Researc
Discovering Causal Relations and Equations from Data
Physics is a field of science that has traditionally used the scientific
method to answer questions about why natural phenomena occur and to make
testable models that explain the phenomena. Discovering equations, laws and
principles that are invariant, robust and causal explanations of the world has
been fundamental in physical sciences throughout the centuries. Discoveries
emerge from observing the world and, when possible, performing interventional
studies in the system under study. With the advent of big data and the use of
data-driven methods, causal and equation discovery fields have grown and made
progress in computer science, physics, statistics, philosophy, and many applied
fields. All these domains are intertwined and can be used to discover causal
relations, physical laws, and equations from observational data. This paper
reviews the concepts, methods, and relevant works on causal and equation
discovery in the broad field of Physics and outlines the most important
challenges and promising future lines of research. We also provide a taxonomy
for observational causal and equation discovery, point out connections, and
showcase a complete set of case studies in Earth and climate sciences, fluid
dynamics and mechanics, and the neurosciences. This review demonstrates that
discovering fundamental laws and causal relations by observing natural
phenomena is being revolutionised with the efficient exploitation of
observational data, modern machine learning algorithms and the interaction with
domain knowledge. Exciting times are ahead with many challenges and
opportunities to improve our understanding of complex systems.Comment: 137 page
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