18,707 research outputs found
Variational Bayes model averaging for graphon functions and motif frequencies inference in W-graph models
W-graph refers to a general class of random graph models that can be seen as
a random graph limit. It is characterized by both its graphon function and its
motif frequencies. In this paper, relying on an existing variational Bayes
algorithm for the stochastic block models along with the corresponding weights
for model averaging, we derive an estimate of the graphon function as an
average of stochastic block models with increasing number of blocks. In the
same framework, we derive the variational posterior frequency of any motif. A
simulation study and an illustration on a social network complete our work
Learning a Hybrid Architecture for Sequence Regression and Annotation
When learning a hidden Markov model (HMM), sequen- tial observations can
often be complemented by real-valued summary response variables generated from
the path of hid- den states. Such settings arise in numerous domains, includ-
ing many applications in biology, like motif discovery and genome annotation.
In this paper, we present a flexible frame- work for jointly modeling both
latent sequence features and the functional mapping that relates the summary
response variables to the hidden state sequence. The algorithm is com- patible
with a rich set of mapping functions. Results show that the availability of
additional continuous response vari- ables can simultaneously improve the
annotation of the se- quential observations and yield good prediction
performance in both synthetic data and real-world datasets.Comment: AAAI 201
Detecting and Describing Dynamic Equilibria in Adaptive Networks
We review modeling attempts for the paradigmatic contact process (or SIS
model) on adaptive networks. Elaborating on one particular proposed mechanism
of topology change (rewiring) and its mean field analysis, we obtain a
coarse-grained view of coevolving network topology in the stationary active
phase of the system. Introducing an alternative framework applicable to a wide
class of adaptive networks, active stationary states are detected, and an
extended description of the resulting steady-state statistics is given for
three different rewiring schemes. We find that slight modifications of the
standard rewiring rule can result in either minuscule or drastic change of
steady-state network topologies.Comment: 14 pages, 10 figures; typo in the third of Eqs. (1) correcte
Three-Dimensional Structure of the Complexin/SNARE Complex
During neurotransmitter release, the neuronal SNARE proteins synaptobrevin/VAMP, syntaxin, and SNAP-25 form a four-helix bundle, the SNARE complex, that pulls the synaptic vesicle and plasma membranes together possibly causing membrane fusion. Complexin binds tightly to the SNARE complex and is essential for efficient Ca2+-evoked neurotransmitter release. A combined X-ray and TROSY-based NMR study now reveals the atomic structure of the complexin/SNARE complex. Complexin binds in an antiparallel α-helical conformation to the groove between the synaptobrevin and syntaxin helices. This interaction stabilizes the interface between these two helices, which bears the repulsive forces between the apposed membranes. These results suggest that complexin stabilizes the fully assembled SNARE complex as a key step that enables the exquisitely high speed of Ca2+-evoked neurotransmitter release
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