Development of the Marketing Strategy of Mediahost.sk on the Czech Market

Diplomová práca sa zameriava na vývoj marketingovej stratégie firmy Mediahost.sk na slovenskom trhu. Analyzuje makro a mikro prostredie v IT priemysle, a to najmä so zameraním na webhosting. Aktuálna marketingová stratégia spoločnosti je popísaná a hlavné ovplyvňujúce faktory sú rozpoznané. Diplomová práca obsahuje návrhy zmien a odporúčania zahrnuté v novej marketingovej stratégii spoločnosti. Navyše, je navrhnutý plán a rozpočet realizácie.The diploma thesis focuses on the development of marketing strategy of company Mediahost.sk in the Czech market. Analyzes macro and micro environment in the IT industry, especially focusing on webhosting. The current marketing strategy of the company is described and main influencing factors are identified. The thesis contains proposals and recommendations included in the new marketing strategy. In addition, the proposed plan and budget are introduced.

Identifying factors likely to influence compliance with diagnostic imaging guideline recommendations for spine disorders among chiropractors in North America: a focus group study using the Theoretical Domains Framework

Background: The Theoretical Domains Framework (TDF) was developed to investigate determinants of specific clinical behaviors and inform the design of interventions to change professional behavior. This framework was used to explore the beliefs of chiropractors in an American Provider Network and two Canadian provinces about their adherence to evidence-based recommendations for spine radiography for uncomplicated back pain. The primary objective of the study was to identify chiropractors’ beliefs about managing uncomplicated back pain without xrays and to explore barriers and facilitators to implementing evidence-based recommendations on lumbar spine xrays. A secondary objective was to compare chiropractors in the United States and Canada on their beliefs regarding the use of spine x-rays. Methods: Six focus groups exploring beliefs about managing back pain without x-rays were conducted with a purposive sample. The interview guide was based upon the TDF. Focus groups were digitally recorded, transcribed verbatim, and analyzed by two independent assessors using thematic content analysis based on the TDF. Results: Five domains were identified as likely relevant. Key beliefs within these domains included the following: conflicting comments about the potential consequences of not ordering x-rays (risk of missing a pathology, avoiding adverse treatment effects, risks of litigation, determining the treatment plan, and using x-ray-driven techniques contrasted with perceived benefits of minimizing patient radiation exposure and reducing costs; beliefs about consequences); beliefs regarding professional autonomy, professional credibility, lack of standardization, and agreement with guidelines widely varied (social/professional role & identity); the influence of formal training, colleagues, and patients also appeared to be important factors (social influences); conflicting comments regarding levels of confidence and comfort in managing patients without x-rays (belief about capabilities); and guideline awareness and agreements (knowledge). Conclusions: Chiropractors’ use of diagnostic imaging appears to be influenced by a number of factors. Five key domains may be important considering the presence of conflicting beliefs, evidence of strong beliefs likely to impact the behavior of interest, and high frequency of beliefs. The results will inform the development of a theorybased survey to help identify potential targets for behavioral-change strategies

Enhancing Ontario’s Rural Infrastructure Preparedness: Inter-Community Service Sharing in a Changing Climate — Environmental Scan

Given the research that has been done in this environmental scan and the gaps found in this research, it is our aim to find out: What types of service sharing are going on in Ontario municipalities, particularly in rural/remote areas? How can inter-community service sharing (ICSS) benefit the asset management planning process in these rural/remote areas to enhance capacities for climate change resilience? Climate change (CC) will exacerbate deterioration to existing infrastructure and increase replacement costs. Improved preparedness reduces risks and increases efficiency, readiness and coping capacity. To increase the preparedness of Ontario rural communities, this project develops CC-Prepared Inter-Community Service Sharing (ICSS) as an innovative strategy that expands cost-effective solutions within Ontario’s standardized Asset Management Planning (AMP) process. Overseen by a Project Advisory Board (PAB), it identifies a suite of best practice ICSS processes and principles and a range of factors and indicators that influence the uptake of ICSS as a viable and practical opportunity targeted to enhance rural infrastructure preparedness for CC. It utilizes a multimethod, interdisciplinary approach involving an environmental scan, interviews, a survey and case studies and develops an ICSS Toolkit consisting of reports, workbook, policy brief and media kit. Knowledge translation and transfer (KTT) includes blogs, teleconferences, articles, presentations and a workshop. For small rural Ontario communities, this study enhances management of CC impacts on infrastructure through the development of a CC-Prepared ICSS strategy, increasing anticipatory, collective actions that reduce dam age and increase efficiencies. It informs sound municipal/provincial level programs and policies about innovative ICSS that benefit rural communities through the identification of Ontario-wide trends, case study best practises and action-oriented recommendations

Research on the Application of E-commerce to Small and Medium Enterprises (SMEs): the Case of India

SMEs account for a large proportion and play an important role in the development of each country in the world, including India. The globalization will bring many advantages for enterprises however SMEs will face fierce competition at the local, national and International level. In order to maintain and promote the important role of SMEs in the context of increased competition, SMEs have to change and adopt new technologies. E-commerce and digital technologies are bringing opportunities to help SMEs improve their competitiveness, narrow the gap with big enterprises thanks to their fairness and flexibility of the digital business environment.       According to UNIDO (2017), India is one of the countries successfully applying e-commerce to SMEs. Contributing to this success is the important role of the Indian government. Therefore, this paper focuses on researching the application of e-commerce to SMEs in terms of the role of government in promoting and creating an ecosystem for SMEs and e-commerce development

AMPK in the central nervous system: physiological roles and pathological implications

5′ AMP-activated protein kinase (AMPK) is considered the master metabolic regulator in all eukaryotes, as it maintains cellular energy homeostasis in a variety of tissues, including the brain. In humans, alterations in AMPK activity can lead to a wide spectrum of metabolic disorders. The relevance of this protein kinase in the pathogenesis of diabetes and metabolic syndrome is now well established. On the contrary, correlations between AMPK and brain physiopathology are still poorly characterized. The aim of this review is to summarize and discuss the current knowledge about the prospective involvement of AMPK in the onset and the progression of different neurological diseases

The oral microbiome of denture wearers is influenced by natural dentition

Objectives: The composition of dental plaque has been well defined, whereas currently there is limited understanding of the composition of denture plaque and how it directly influences denture related stomatitis (DS). The aims of this study were to compare the microbiomes of denture wearers, and to understand the implications of these towards inter-kingdom and host-pathogen interactions within the oral cavity. Methods: Swab samples were obtained from 123 participants wearing either a complete or partial denture; the bacterial composition of each sample was determined using bar-coded illumina MiSeq sequencing of the bacterial hypervariable V4 region of 16S rDNA. Sequencing data processing was undertaken using QIIME, clustered in Operational Taxonomic Units (OTUs) and assigned to taxonomy. The dentures were sonicated to remove the microbial flora residing on the prosthesis, sonicate was then cultured using diagnostic colorex Candida media. Samples of unstimulated saliva were obtained and antimicrobial peptides (AMP) levels were measured by ELISA. Results: We have shown that dental and denture plaques are significantly distinct both in composition and diversity and that the oral microbiome composition of a denture wearer is variable and is influenced by the location within the mouth. Dentures and mucosa were predominantly made up of Bacilli and Actinobacteria. Moreover, the presence of natural teeth has a significant impact on the overall microbial composition, when compared to the fully edentulous. Furthermore, increasing levels of Candida spp. positively correlate with Lactobacillus spp. AMPs were quantified, though showed no specific correlations. Conclusions: This is the first study to provide a detailed understanding of the oral microbiome of denture wearers and has provided evidence that DS development is more complex than simply a candidal infection. Both fungal and bacterial kingdoms clearly play a role in defining the progression of DS, though we were unable to show a defined role for AMPs

Could gestational diabetes mellitus be managed through dietary bioactive compounds? Current knowledge and future perspectives

Gestational diabetes mellitus (GDM) is a serious problem growing worldwide that needs to be addressed with urgency in consideration of the resulting severe complications for both mother and fetus. Growing evidence indicates that a healthy diet rich in fruit, vegetables, nuts, extra-virgin olive oil and fish has beneficial effects in both the prevention and management of several human diseases and metabolic disorders. In this review, we discuss the latest data concerning the effects of dietary bioactive compounds such as polyphenols and PUFA on the molecular mechanisms regulating glucose homoeostasis. Several studies, mostly based on in vitro and animal models, indicate that dietary polyphenols, mainly flavonoids, positively modulate the insulin signalling pathway by attenuating hyperglycaemia and insulin resistance, reducing inflammatory adipokines, and modifying microRNA (miRNA) profiles. Very few data about the influence of dietary exposure on GDM outcomes are available, although this approach deserves careful consideration. Further investigation, which includes exploring the 'omics' world, is needed to better understand the complex interaction between dietary compounds and GDM

Insights on Lymphedema Self-Care Knowledge and Practice in Filariasis and Podoconiosis-Endemic Communities in Bangladesh and Ethiopia

Lymphedema is a life-long sequelae to several neglected tropical diseases (NTD). In Bangladesh the main cause is lymphatic filariasis (LF) and Ethiopia is endemic for both LF and podoconiosis. The World Health Organization (WHO) recommends daily self-care including meticulous washing and drying of affected skin and attention to entry lesions, limb exercises and elevation. Adherence to this regime reduces secondary infections which cause disabling episodes of acute dermato-lymphangitis (ADL). Self-care practices must be integrated into family life, supported by community and monitored by health staff; however, little is known about the influence of personal and socio-demographic factors on adherence. People affected by lymphedema (n=272), adult caregivers (n=272), and health workers (n=68) in Bangladesh and Ethiopia were trained in lymphedema management according to WHO recommendations. Surveys on the causes and management of lymphedema were collected at baseline and 24-weeks, and patients completed a daily journal of self-care activities and symptoms. At baseline knowledge on causes and management of lymphedema was greater among health workers (&amp;gt;70%) than patients and caregivers (&amp;lt;20%) in both countries, and there were significant between-country differences in patient reported use of limb washing (Bangladesh = 7.7%. Ethiopia = 51.1%, p = 0.001). At 24-weeks knowledge on lymphedema causes and management had increased significantly among patients and caregivers, there was &amp;lt;70% adherence to limb washing and exercises, but lesser use of limb elevation in both countries. A range of patient characteristics were associated with significant variation in self-care, except for limb washing. Performance of fewer leg exercises was significantly associated with increased age or severe lymphedema in Bangladesh, and with being female or in paid work in Ethiopia. Patient journals recorded ADL symptoms and working days lost due to lymphedema more frequently than were reported by recall during the 24-week survey. Core elements of lymphedema self-care education, training and monitoring are the same for multiple etiologies. This creates opportunities for cross-cutting implementation of integrated service delivery across several skin NTDs. Sustainability will depend on community level ownership and research on factors affecting adherence to lymphedema self-care are urgently needed.</jats:p

Antimicrobial Peptides and Skin: A Paradigm of Translational Medicine

Antimicrobial peptides (AMPs) are small, cationic, amphiphilic peptides with broad-spectrum microbicidal activity against both bacteria and fungi. In mammals, AMPs form the first line of host defense against infections and generally play an important role as effector agents of the innate immune system. The AMP era was born more than 6 decades ago when the first cationic cyclic peptide antibiotics, namely polymyxins and tyrothricin, found their way into clinical use. Due to the good clinical experience in the treatment of, for example, infections of mucus membranes as well as the subsequent understanding of mode of action, AMPs are now considered for treatment of inflammatory skin diseases and for improving healing of infected wounds. Based on the preclinical findings, including pathobiochemistry and molecular medicine, targeted therapy strategies are developed and first results indicate that AMPs influence processes of diseased skin. Importantly, in contrast to other antibiotics, AMPs do not seem to propagate the development of antibiotic-resistant micro-organisms. Therefore, AMPs should be tested in clinical trials for their efficacy and tolerability in inflammatory skin diseases and chronic wounds. Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a `two-way road' - from bench to bedside and backwards from bedside to bench. Copyright (c) 2012 S. Karger AG, Base

Determinants of Financial Performance of Commercial Dairy Farms.

Data from the 1993 Farm Costs and Returns Survey were used in a multi-variate analysis framework to determine factors associated with the financial performance of commercial dairy farm operations. Statistical equivalency tests revealed regional differences in the way extensive indebtedness, size of operation, and labor cost affect net farm incomes. Regional differences were also found in terms of how milk production per cow, per-unit cost of purchased feed, and level of adoption of capital intensive technologies affect per-unit returns. Examination of the variation in the net farm income of commercial dairy farms using the method of coefficients of separate determination identified the size of the operation, regardless of the location of the farm business, as the factor contributing the most to the variability in net farm income. On a per-unit-of-returns basis, factors found most important in explaining the variation in net returns per hundredweight of milk sold were cow's productivity, and per-cow forage production and purchased feed costs.financial performance, net farm income, technological adoption, Lorenz curve, Gini coefficient, Agricultural Finance, Livestock Production/Industries,