Combined effect of neolamarckia cadamba leaves and electroporation method on hela cell anti- proliferation process

This study suggests that natural sources may become an important tool in treating cancer. Neolamarckia cadamba (NC) leaves also well-known as “Anthocephalus Cadamba”, is a precious plant in Ayurvedic medicine. HeLa cells are one of the examples of eukaryotic cells type. It is derived from human cervical cancer cells. This experiment is conducted in different concentrations of NC Leaves (1μg/ml, 5μg/ml, 10μg/ml, 20μg/ml, 30μg/ml, 40μg/ml, 50μg/ml, 60μg/ml, 70μg/ml, 80μg/ml, 90μg/ml and 100μg/ml) for 48 hours. This experiment’s result proves that the anti-cancer properties of the extract of NC leaves are by increasing the concentration of extract, the numbers of cell viability will decrease. For contribution, the process of NC leaves extract will be combined with the electroporation process to investigate the effect on HeLa cell. Electroporation parameters used for this study were (voltage 600v/cm, pulse duration 5ms, single pulse)

Efficient reconfigurable architectures for 3D medical image compression

This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Recently, the more widespread use of three-dimensional (3-D) imaging modalities, such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound (US) have generated a massive amount of volumetric data. These have provided an impetus to the development of other applications, in particular telemedicine and teleradiology. In these fields, medical image compression is important since both efficient storage and transmission of data through high-bandwidth digital communication lines are of crucial importance. Despite their advantages, most 3-D medical imaging algorithms are computationally intensive with matrix transformation as the most fundamental operation involved in the transform-based methods. Therefore, there is a real need for high-performance systems, whilst keeping architectures exible to allow for quick upgradeability with real-time applications. Moreover, in order to obtain efficient solutions for large medical volumes data, an efficient implementation of these operations is of significant importance. Reconfigurable hardware, in the form of field programmable gate arrays (FPGAs) has been proposed as viable system building block in the construction of high-performance systems at an economical price. Consequently, FPGAs seem an ideal candidate to harness and exploit their inherent advantages such as massive parallelism capabilities, multimillion gate counts, and special low-power packages. The key achievements of the work presented in this thesis are summarised as follows. Two architectures for 3-D Haar wavelet transform (HWT) have been proposed based on transpose-based computation and partial reconfiguration suitable for 3-D medical imaging applications. These applications require continuous hardware servicing, and as a result dynamic partial reconfiguration (DPR) has been introduced. Comparative study for both non-partial and partial reconfiguration implementation has shown that DPR offers many advantages and leads to a compelling solution for implementing computationally intensive applications such as 3-D medical image compression. Using DPR, several large systems are mapped to small hardware resources, and the area, power consumption as well as maximum frequency are optimised and improved. Moreover, an FPGA-based architecture of the finite Radon transform (FRAT)with three design strategies has been proposed: direct implementation of pseudo-code with a sequential or pipelined description, and block random access memory (BRAM)- based method. An analysis with various medical imaging modalities has been carried out. Results obtained for image de-noising implementation using FRAT exhibits promising results in reducing Gaussian white noise in medical images. In terms of hardware implementation, promising trade-offs on maximum frequency, throughput and area are also achieved. Furthermore, a novel hardware implementation of 3-D medical image compression system with context-based adaptive variable length coding (CAVLC) has been proposed. An evaluation of the 3-D integer transform (IT) and the discrete wavelet transform (DWT) with lifting scheme (LS) for transform blocks reveal that 3-D IT demonstrates better computational complexity than the 3-D DWT, whilst the 3-D DWT with LS exhibits a lossless compression that is significantly useful for medical image compression. Additionally, an architecture of CAVLC that is capable of compressing high-definition (HD) images in real-time without any buffer between the quantiser and the entropy coder is proposed. Through a judicious parallelisation, promising results have been obtained with limited resources. In summary, this research is tackling the issues of massive 3-D medical volumes data that requires compression as well as hardware implementation to accelerate the slowest operations in the system. Results obtained also reveal a significant achievement in terms of the architecture efficiency and applications performance.Ministry of Higher Education Malaysia (MOHE), Universiti Tun Hussein Onn Malaysia (UTHM) and the British Counci

Mengenal pasti tahap pengetahuan pelajar tahun akhir Ijazah Sarjana Muda Kejuruteraan di KUiTTHO dalam bidang keusahawanan dari aspek pengurusan modal

Malaysia ialah sebuah negara membangun di dunia. Dalam proses pembangunan ini, hasrat negara untuk melahirkan bakal usahawan beijaya tidak boleh dipandang ringan. Oleh itu, pengetahuan dalam bidang keusahawanan perlu diberi perhatian dengan sewajarnya; antara aspek utama dalam keusahawanan ialah modal. Pengurusan modal yang tidak cekap menjadi punca utama kegagalan usahawan. Menyedari hakikat ini, kajian berkaitan Pengurusan Modal dijalankan ke atas 100 orang pelajar Tahun Akhir Kejuruteraan di KUiTTHO. Sampel ini dipilih kerana pelajar-pelajar ini akan menempuhi alam pekeijaan di mana mereka boleh memilih keusahawanan sebagai satu keijaya. Walau pun mereka bukanlah pelajar dari jurusan perniagaan, namun mereka mempunyai kemahiran dalam mereka cipta produk yang boleh dikomersialkan. Hasil dapatan kajian membuktikan bahawa pelajar-pelajar ini berminat dalam bidang keusahawanan namun masih kurang pengetahuan tentang pengurusan modal terutamanya dalam menentukan modal permulaan, pengurusan modal keija dan caracara menentukan pembiayaan kewangan menggunakan kaedah jualan harian. Oleh itu, satu garis panduan Pengurusan Modal dibina untuk memberi pendedahan kepada mereka

A multimedia courseware for human heart anatomical and functional illustration

Advances in computer science have provided unique opportunities to apply Interactive Multimedia (IMM) courseware to a wide variety of medical and health care functions. Courseware can be called an easy to learn, teachable and course materials which is an important in Information Communication Technology world today. It helps the learners/students to improve their knowledge, skills and creativity. One area which holds the high ability for using computer systems is medical and health science education. This paper describes the design of an IMM courseware for learning about Human Heart. It proposes a Human Heart Anatomical and Functional Illustration (HHAFI) courseware for students, health officials and everyone interested in having a healthy heart. The HHAFI courseware is implemented by Toolbook Instructor and presented on Windows platform. The courseware includes an introduction that describes the heart and recall such as mechanisms of the heart, heart diseases, healthy tips and living a healthy lifestyle. The HHAFI courseware is tested with the student to identify the improvement in their knowledge and measure the level of interest in the topic. The HHAFI courseware provides learning and interactive training functions for interested individuals

Efficient architectures of heterogeneous fpga-gpu for 3-d medical image compression

The advent of development in three-dimensional (3-D) imaging modalities have generated a massive amount of volumetric data in 3-D images such as magnetic resonance imaging (MRI), computed tomography (CT), positron emission tomography (PET), and ultrasound (US). Existing survey reveals the presence of a huge gap for further research in exploiting reconfigurable computing for 3-D medical image compression. This research proposes an FPGA based co-processing solution to accelerate the mentioned medical imaging system. The HWT block implemented on the sbRIO-9632 FPGA board is Spartan 3 (XC3S2000) chip prototyping board. Analysis and performance evaluation of the 3-D images were been conducted. Furthermore, a novel architecture of context-based adaptive binary arithmetic coder (CABAC) is the advanced entropy coding tool employed by main and higher profiles of H.264/AVC. This research focuses on GPU implementation of CABAC and comparative study of discrete wavelet transform (DWT) and without DWT for 3-D medical image compression systems. Implementation results on MRI and CT images, showing GPU significantly outperforming single-threaded CPU implementation. Overall, CT and MRI modalities with DWT outperform in term of compression ratio, peak signal to noise ratio (PSNR) and latency compared with images without DWT process. For heterogeneous computing, MRI images with various sizes and format, such as JPEG and DICOM was implemented. Evaluation results are shown for each memory iteration, transfer sizes from GPU to CPU consuming more bandwidth or throughput. For size 786, 486 bytes JPEG format, both directions consumed bandwidth tend to balance. Bandwidth is relative to the transfer size, the larger sizing will take more latency and throughput. Next, OpenCL implementation for concurrent task via dedicated FPGA. Finding from implementation reveals, OpenCL on batch procession mode with AOC techniques offers substantial results where the amount of logic, area, register and memory increased proportionally to the number of batch. It is because of the kernel will copy the kernel block refer to batch number. Therefore memory bank increased periodically related to kernel block. It was found through comparative study that the tree balance and unroll loop architecture provides better achievement, in term of local memory, latency and throughput

Survey of FPGA applications in the period 2000 – 2015 (Technical Report)

Romoth J, Porrmann M, Rückert U. Survey of FPGA applications in the period 2000 – 2015 (Technical Report).; 2017.Since their introduction, FPGAs can be seen in more and more different fields of applications. The key advantage is the combination of software-like flexibility with the performance otherwise common to hardware. Nevertheless, every application field introduces special requirements to the used computational architecture. This paper provides an overview of the different topics FPGAs have been used for in the last 15 years of research and why they have been chosen over other processing units like e.g. CPUs

In search for the best wavelet for denoising low SNR RF Signal for FMCW Radar Altimeter

This research project / thesis proposes the best wavelet for Denoising under low Signal to Noise Ratio (SNR) conditions and Discrete Wavelet Transform Architecture based design for RF signal denoising, targeting the real time applications like FMCW (Frequency Modulated Continuous Wave) Radar Altimeter used in Anti-Radiation Missiles, Smart Bombs, Fighter aircrafts, Helicopters etc., and other Defense and RF carrier based applications like Cellular communication. DWT (Discrete Wavelet Transform) & IDWT(Inverse DWT) Architecture Models designed in MATLAB for the wavelets under study like dmey, coif1, sym2, & debouches db1, db2, db3, db4, db6. The reconstructed signal results after denoising are compared in various aspects. The results show that db3 is the best wavelet for denoising application point of view. Finally the db3 based architecture design implemented in VHDL(VHSIC Hardware Description Language) and the simulation results compared, synthesis has been done using Xilinx ISE Design suite targeting an FPGA. This project involves study and implementation of De-noising algorithms using Discrete Wavelet Transform. In a system the signal to noise ratio (SNR) is important for reliable information retrieval. Analysis of signals with poor SNR may lead to wrong interpretation of results. Conventional techniques like filtering in time domain and frequency domain has its own limitations in estimating and characterizing noise. Wavelet transforms is a very useful tool in the analysis of non-stationary signals. Wavelet transform has been used in signal processing fields such as de noising or data compression. This method consists of decomposing the data recursively into a sum of details and approximations at different levels of resolution. The details represent the high frequency components while the approximations represent the low frequency components of the signal

Pattern Recognition

Pattern recognition is a very wide research field. It involves factors as diverse as sensors, feature extraction, pattern classification, decision fusion, applications and others. The signals processed are commonly one, two or three dimensional, the processing is done in real- time or takes hours and days, some systems look for one narrow object class, others search huge databases for entries with at least a small amount of similarity. No single person can claim expertise across the whole field, which develops rapidly, updates its paradigms and comprehends several philosophical approaches. This book reflects this diversity by presenting a selection of recent developments within the area of pattern recognition and related fields. It covers theoretical advances in classification and feature extraction as well as application-oriented works. Authors of these 25 works present and advocate recent achievements of their research related to the field of pattern recognition

Real-time Ultrasound Signals Processing: Denoising and Super-resolution

Ultrasound acquisition is widespread in the biomedical field, due to its properties of low cost, portability, and non-invasiveness for the patient. The processing and analysis of US signals, such as images, 2D videos, and volumetric images, allows the physician to monitor the evolution of the patient's disease, and support diagnosis, and treatments (e.g., surgery). US images are affected by speckle noise, generated by the overlap of US waves. Furthermore, low-resolution images are acquired when a high acquisition frequency is applied to accurately characterise the behaviour of anatomical features that quickly change over time. Denoising and super-resolution of US signals are relevant to improve the visual evaluation of the physician and the performance and accuracy of processing methods, such as segmentation and classification. The main requirements for the processing and analysis of US signals are real-time execution, preservation of anatomical features, and reduction of artefacts. In this context, we present a novel framework for the real-time denoising of US 2D images based on deep learning and high-performance computing, which reduces noise while preserving anatomical features in real-time execution. We extend our framework to the denoise of arbitrary US signals, such as 2D videos and 3D images, and we apply denoising algorithms that account for spatio-temporal signal properties into an image-to-image deep learning model. As a building block of this framework, we propose a novel denoising method belonging to the class of low-rank approximations, which learns and predicts the optimal thresholds of the Singular Value Decomposition. While previous denoise work compromises the computational cost and effectiveness of the method, the proposed framework achieves the results of the best denoising algorithms in terms of noise removal, anatomical feature preservation, and geometric and texture properties conservation, in a real-time execution that respects industrial constraints. The framework reduces the artefacts (e.g., blurring) and preserves the spatio-temporal consistency among frames/slices; also, it is general to the denoising algorithm, anatomical district, and noise intensity. Then, we introduce a novel framework for the real-time reconstruction of the non-acquired scan lines through an interpolating method; a deep learning model improves the results of the interpolation to match the target image (i.e., the high-resolution image). We improve the accuracy of the prediction of the reconstructed lines through the design of the network architecture and the loss function. %The design of the deep learning architecture and the loss function allow the network to improve the accuracy of the prediction of the reconstructed lines. In the context of signal approximation, we introduce our kernel-based sampling method for the reconstruction of 2D and 3D signals defined on regular and irregular grids, with an application to US 2D and 3D images. Our method improves previous work in terms of sampling quality, approximation accuracy, and geometry reconstruction with a slightly higher computational cost. For both denoising and super-resolution, we evaluate the compliance with the real-time requirement of US applications in the medical domain and provide a quantitative evaluation of denoising and super-resolution methods on US and synthetic images. Finally, we discuss the role of denoising and super-resolution as pre-processing steps for segmentation and predictive analysis of breast pathologies