362 research outputs found
Biomedical relation extraction:from binary to complex
Biomedical relation extraction aims to uncover high-quality relations from life science literature with high accuracy and efficiency. Early biomedical relation extraction tasks focused on capturing binary relations, such as protein-protein interactions, which are crucial for virtually every process in a living cell. Information about these interactions provides the foundations for new therapeutic approaches. In recent years, more interests have been shifted to the extraction of complex relations such as biomolecular events. While complex relations go beyond binary relations and involve more than two arguments, they might also take another relation as an argument. In the paper, we conduct a thorough survey on the research in biomedical relation extraction. We first present a general framework for biomedical relation extraction and then discuss the approaches proposed for binary and complex relation extraction with focus on the latter since it is a much more difficult task compared to binary relation extraction. Finally, we discuss challenges that we are facing with complex relation extraction and outline possible solutions and future directions
The Materials Science Procedural Text Corpus: Annotating Materials Synthesis Procedures with Shallow Semantic Structures
Materials science literature contains millions of materials synthesis
procedures described in unstructured natural language text. Large-scale
analysis of these synthesis procedures would facilitate deeper scientific
understanding of materials synthesis and enable automated synthesis planning.
Such analysis requires extracting structured representations of synthesis
procedures from the raw text as a first step. To facilitate the training and
evaluation of synthesis extraction models, we introduce a dataset of 230
synthesis procedures annotated by domain experts with labeled graphs that
express the semantics of the synthesis sentences. The nodes in this graph are
synthesis operations and their typed arguments, and labeled edges specify
relations between the nodes. We describe this new resource in detail and
highlight some specific challenges to annotating scientific text with shallow
semantic structure. We make the corpus available to the community to promote
further research and development of scientific information extraction systems.Comment: Accepted as a long paper at the Linguistic Annotation Workshop (LAW)
at ACL 201
A text-mining system for extracting metabolic reactions from full-text articles
Background: Increasingly biological text mining research is focusing on the extraction of complex relationships
relevant to the construction and curation of biological networks and pathways. However, one important category of
pathway—metabolic pathways—has been largely neglected.
Here we present a relatively simple method for extracting metabolic reaction information from free text that scores
different permutations of assigned entities (enzymes and metabolites) within a given sentence based on the presence
and location of stemmed keywords. This method extends an approach that has proved effective in the context of the
extraction of protein–protein interactions.
Results: When evaluated on a set of manually-curated metabolic pathways using standard performance criteria, our
method performs surprisingly well. Precision and recall rates are comparable to those previously achieved for the
well-known protein-protein interaction extraction task.
Conclusions: We conclude that automated metabolic pathway construction is more tractable than has often been
assumed, and that (as in the case of protein–protein interaction extraction) relatively simple text-mining approaches can prove surprisingly effective. It is hoped that these results will provide an impetus to further research and act as a useful benchmark for judging the performance of more sophisticated methods that are yet to be developed
An analysis of gene/protein associations at PubMed scale
<p>Abstract</p> <p>Background</p> <p>Event extraction following the GENIA Event corpus and BioNLP shared task models has been a considerable focus of recent work in biomedical information extraction. This work includes efforts applying event extraction methods to the entire PubMed literature database, far beyond the narrow subdomains of biomedicine for which annotated resources for extraction method development are available.</p> <p>Results</p> <p>In the present study, our aim is to estimate the coverage of all statements of gene/protein associations in PubMed that existing resources for event extraction can provide. We base our analysis on a recently released corpus automatically annotated for gene/protein entities and syntactic analyses covering the entire PubMed, and use named entity co-occurrence, shortest dependency paths and an unlexicalized classifier to identify likely statements of gene/protein associations. A set of high-frequency/high-likelihood association statements are then manually analyzed with reference to the GENIA ontology.</p> <p>Conclusions</p> <p>We present a first estimate of the overall coverage of gene/protein associations provided by existing resources for event extraction. Our results suggest that for event-type associations this coverage may be over 90%. We also identify several biologically significant associations of genes and proteins that are not addressed by these resources, suggesting directions for further extension of extraction coverage.</p
Exploring Biomolecular Literature with EVEX: Connecting Genes through Events, Homology, and Indirect Associations
Technological advancements in the field of genetics have led not only to an abundance of experimental data, but also caused an exponential increase of the number of published biomolecular studies. Text mining is widely accepted as a promising technique to help researchers in the life sciences deal with the amount of available literature. This paper presents a freely available web application built on top of 21.3 million detailed biomolecular events extracted from all PubMed abstracts. These text mining results were generated by a state-of-the-art event extraction system and enriched with gene family associations and abstract generalizations, accounting for lexical variants and synonymy. The EVEX resource locates relevant literature on phosphorylation, regulation targets, binding partners, and several other biomolecular events and assigns confidence values to these events. The search function accepts official gene/protein symbols as well as common names from all species. Finally, the web application is a powerful tool for generating homology-based hypotheses as well as novel, indirect associations between genes and proteins such as coregulators
Biomedical Event Extraction with Machine Learning
Biomedical natural language processing (BioNLP) is a subfield of natural
language processing, an area of computational linguistics concerned with
developing programs that work with natural language: written texts and
speech. Biomedical relation extraction concerns the detection of semantic
relations such as protein-protein interactions (PPI) from scientific texts.
The aim is to enhance information retrieval by detecting relations between
concepts, not just individual concepts as with a keyword search.
In recent years, events have been proposed as a more detailed alternative
for simple pairwise PPI relations. Events provide a systematic, structural
representation for annotating the content of natural language texts. Events
are characterized by annotated trigger words, directed and typed arguments
and the ability to nest other events. For example, the sentence “Protein A
causes protein B to bind protein C” can be annotated with the nested event
structure CAUSE(A, BIND(B, C)). Converted to such formal representations,
the information of natural language texts can be used by computational
applications. Biomedical event annotations were introduced by the
BioInfer and GENIA corpora, and event extraction was popularized by the
BioNLP'09 Shared Task on Event Extraction.
In this thesis we present a method for automated event extraction, implemented
as the Turku Event Extraction System (TEES). A unified graph
format is defined for representing event annotations and the problem of
extracting complex event structures is decomposed into a number of independent
classification tasks. These classification tasks are solved using SVM
and RLS classifiers, utilizing rich feature representations built from full dependency
parsing. Building on earlier work on pairwise relation extraction
and using a generalized graph representation, the resulting TEES system is
capable of detecting binary relations as well as complex event structures.
We show that this event extraction system has good performance, reaching
the first place in the BioNLP'09 Shared Task on Event Extraction.
Subsequently, TEES has achieved several first ranks in the BioNLP'11 and
BioNLP'13 Shared Tasks, as well as shown competitive performance in the
binary relation Drug-Drug Interaction Extraction 2011 and 2013 shared
tasks.
The Turku Event Extraction System is published as a freely available
open-source project, documenting the research in detail as well as making
the method available for practical applications. In particular, in this thesis
we describe the application of the event extraction method to PubMed-scale
text mining, showing how the developed approach not only shows good
performance, but is generalizable and applicable to large-scale real-world
text mining projects.
Finally, we discuss related literature, summarize the contributions of the
work and present some thoughts on future directions for biomedical event
extraction. This thesis includes and builds on six original research publications.
The first of these introduces the analysis of dependency parses that
leads to development of TEES. The entries in the three BioNLP Shared
Tasks, as well as in the DDIExtraction 2011 task are covered in four publications,
and the sixth one demonstrates the application of the system to
PubMed-scale text mining.Siirretty Doriast
Semantically linking molecular entities in literature through entity relationships
Background Text mining tools have gained popularity to process the vast amount of available research articles in the biomedical literature. It is crucial that such tools extract information with a sufficient level of detail to be applicable in real life scenarios. Studies of mining non-causal molecular relations attribute to this goal by formally identifying the relations between genes, promoters, complexes and various other molecular entities found in text. More importantly, these studies help to enhance integration of text mining results with database facts. Results We describe, compare and evaluate two frameworks developed for the prediction of non-causal or 'entity' relations (REL) between gene symbols and domain terms. For the corresponding REL challenge of the BioNLP Shared Task of 2011, these systems ranked first (57.7% F-score) and second (41.6% F-score). In this paper, we investigate the performance discrepancy of 16 percentage points by benchmarking on a related and more extensive dataset, analysing the contribution of both the term detection and relation extraction modules. We further construct a hybrid system combining the two frameworks and experiment with intersection and union combinations, achieving respectively high-precision and high-recall results. Finally, we highlight extremely high-performance results (F-score > 90%) obtained for the specific subclass of embedded entity relations that are essential for integrating text mining predictions with database facts. Conclusions The results from this study will enable us in the near future to annotate semantic relations between molecular entities in the entire scientific literature available through PubMed. The recent release of the EVEX dataset, containing biomolecular event predictions for millions of PubMed articles, is an interesting and exciting opportunity to overlay these entity relations with event predictions on a literature-wide scale
Biomedical Event Extraction with Machine Learning
Biomedical natural language processing (BioNLP) is a subfield of natural
language processing, an area of computational linguistics concerned
with developing programs that work with natural language: written texts and
speech. Biomedical relation extraction concerns the detection of
semantic relations such as protein--protein interactions (PPI) from scientific
texts. The aim is to enhance information retrieval by detecting relations
between concepts, not just individual concepts as with a keyword search.
In recent years, events have been proposed as a more detailed alternative for
simple pairwise PPI relations. Events provide a systematic, structural
representation for annotating the content of natural language texts. Events are
characterized by annotated trigger words, directed and typed arguments and the
ability to nest other events. For example, the sentence ``Protein A causes
protein B to bind protein C'' can be annotated with the nested event structure
CAUSE(A, BIND(B, C)). Converted to such formal representations, the
information of natural language texts can be used by computational
applications. Biomedical event annotations were introduced by the BioInfer and
GENIA corpora, and event extraction was popularized by the BioNLP'09 Shared Task
on Event Extraction.
In this thesis we present a method for automated event extraction, implemented
as the Turku Event Extraction System (TEES). A unified graph format is defined
for representing event annotations and the problem of extracting complex event
structures is decomposed into a number of independent classification tasks.
These classification tasks are solved using SVM and RLS classifiers, utilizing
rich feature representations built from full dependency parsing. Building on
earlier work on pairwise relation extraction and using a generalized graph
representation, the resulting TEES system is capable of detecting binary
relations as well as complex event structures.
We show that this event extraction system has good performance,
reaching the first place in the BioNLP'09 Shared Task on Event Extraction. Subsequently,
TEES has achieved several first ranks in the BioNLP'11 and BioNLP'13 Shared
Tasks, as well as shown competitive performance in the binary relation Drug-Drug
Interaction Extraction 2011 and 2013 shared tasks.
The Turku Event Extraction System is published as a freely available open-source
project, documenting the research in detail as well as making the method
available for practical applications. In particular, in this thesis we
describe the application of the event extraction method to PubMed-scale text
mining, showing how the developed approach not only shows good performance, but
is generalizable and applicable to large-scale real-world text mining projects.
Finally, we discuss related literature, summarize the contributions of the work
and present some thoughts on future directions for biomedical event extraction.
This thesis includes and builds on six original research publications. The first
of these introduces the analysis of dependency parses that leads to
development of TEES. The entries in the three BioNLP Shared Tasks, as well as
in the DDIExtraction 2011 task are covered in four publications, and the sixth
one demonstrates the application of the system to PubMed-scale text mining.</p
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