2,774 research outputs found

    Undergraduate Catalog of Studies, 2023-2024

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    Graduate Catalog of Studies, 2023-2024

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    Brittle-viscous deformation cycles at the base of the seismogenic zone in the continental crust

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    The main goal of the study was to determine the dynamical cycle of ductile-brittle deformation and to characterise the fluid pathways at different scales of a brittle-viscous fault zone active at the base of the seismogenic crust. Object of analysis are samples from the sinistral strike-slip fault zone BFZ045 from Olkiluoto (SW Finland), located at the site of a deep geological repository for nuclear waste. Combined microstructural analysis, electron backscatter diffraction (EBSD), and mineral chemistry were applied to reconstruct the variations in pressure, temperature, fluid pressure, and differential stress that mediated deformation and strain localization along BFZ045 across the BDTZ. Ductile deformation took place at 400-500° C and 3-4 kbar, and recrystallized grain size piezometry for quartz document a progressive increase in differential stress during mylonitization, from ca. 50 MPa to ca. 120 MPa. The increase in differential stress was localised towards the shear zone center, which was eventually overprinted by brittle deformation in a narrowing shear zone. Cataclastic deformation occurred under lower T conditions down to T ≄ 320° C and was not further overprinted by mylonitic creep. Porosity estimates were obtained through the combination of x-ray micro-computed tomography (”CT), mercury intrusion porosimetry, He pycnometry, and microstructural analysis. Low porosity values (0.8-4.4%) for different rock type, 2-20 ”m pore size, representative of pore connectivity, and microstructural observation suggest a relationship to a dynamical cycle of fracturing and sealing mechanism, mostly controlled by ductile deformation. Similarly, the observation from fracture orientation analysis indicates that the mylonitic precursor of BFZ045 played an important role in the localization of the brittle deformation. This thesis highlights that the ductile-brittle deformation cycle in BFZ045 was controlled by transient oscillations in fluid pressure in a narrowing shear zone deforming at progressively higher differential stress during cooling

    Graduate Catalog of Studies, 2023-2024

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    Multidisciplinary perspectives on Artificial Intelligence and the law

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    This open access book presents an interdisciplinary, multi-authored, edited collection of chapters on Artificial Intelligence (‘AI’) and the Law. AI technology has come to play a central role in the modern data economy. Through a combination of increased computing power, the growing availability of data and the advancement of algorithms, AI has now become an umbrella term for some of the most transformational technological breakthroughs of this age. The importance of AI stems from both the opportunities that it offers and the challenges that it entails. While AI applications hold the promise of economic growth and efficiency gains, they also create significant risks and uncertainty. The potential and perils of AI have thus come to dominate modern discussions of technology and ethics – and although AI was initially allowed to largely develop without guidelines or rules, few would deny that the law is set to play a fundamental role in shaping the future of AI. As the debate over AI is far from over, the need for rigorous analysis has never been greater. This book thus brings together contributors from different fields and backgrounds to explore how the law might provide answers to some of the most pressing questions raised by AI. An outcome of the Católica Research Centre for the Future of Law and its interdisciplinary working group on Law and Artificial Intelligence, it includes contributions by leading scholars in the fields of technology, ethics and the law.info:eu-repo/semantics/publishedVersio

    On the robustness of Bayesian phylogenetic gene tree estimation

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    Design of new algorithms for gene network reconstruction applied to in silico modeling of biomedical data

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    Programa de Doctorado en BiotecnologĂ­a, IngenierĂ­a y TecnologĂ­a QuĂ­micaLĂ­nea de InvestigaciĂłn: IngenierĂ­a, Ciencia de Datos y BioinformĂĄticaClave Programa: DBICĂłdigo LĂ­nea: 111The root causes of disease are still poorly understood. The success of current therapies is limited because persistent diseases are frequently treated based on their symptoms rather than the underlying cause of the disease. Therefore, biomedical research is experiencing a technology-driven shift to data-driven holistic approaches to better characterize the molecular mechanisms causing disease. Using omics data as an input, emerging disciplines like network biology attempt to model the relationships between biomolecules. To this effect, gene co- expression networks arise as a promising tool for deciphering the relationships between genes in large transcriptomic datasets. However, because of their low specificity and high false positive rate, they demonstrate a limited capacity to retrieve the disrupted mechanisms that lead to disease onset, progression, and maintenance. Within the context of statistical modeling, we dove deeper into the reconstruction of gene co-expression networks with the specific goal of discovering disease-specific features directly from expression data. Using ensemble techniques, which combine the results of various metrics, we were able to more precisely capture biologically significant relationships between genes. We were able to find de novo potential disease-specific features with the help of prior biological knowledge and the development of new network inference techniques. Through our different approaches, we analyzed large gene sets across multiple samples and used gene expression as a surrogate marker for the inherent biological processes, reconstructing robust gene co-expression networks that are simple to explore. By mining disease-specific gene co-expression networks we come up with a useful framework for identifying new omics-phenotype associations from conditional expression datasets.In this sense, understanding diseases from the perspective of biological network perturbations will improve personalized medicine, impacting rational biomarker discovery, patient stratification and drug design, and ultimately leading to more targeted therapies.Universidad Pablo de Olavide de Sevilla. Departamento de Deporte e InformĂĄtic

    2023-2024 Catalog

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    The 2023-2024 Governors State University Undergraduate and Graduate Catalog is a comprehensive listing of current information regarding:Degree RequirementsCourse OfferingsUndergraduate and Graduate Rules and Regulation

    Proceedings of SIRM 2023 - The 15th European Conference on Rotordynamics

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    It was our great honor and pleasure to host the SIRM Conference after 2003 and 2011 for the third time in Darmstadt. Rotordynamics covers a huge variety of different applications and challenges which are all in the scope of this conference. The conference was opened with a keynote lecture given by Rainer Nordmann, one of the three founders of SIRM “Schwingungen in rotierenden Maschinen”. In total 53 papers passed our strict review process and were presented. This impressively shows that rotordynamics is relevant as ever. These contributions cover a very wide spectrum of session topics: fluid bearings and seals; air foil bearings; magnetic bearings; rotor blade interaction; rotor fluid interactions; unbalance and balancing; vibrations in turbomachines; vibration control; instability; electrical machines; monitoring, identification and diagnosis; advanced numerical tools and nonlinearities as well as general rotordynamics. The international character of the conference has been significantly enhanced by the Scientific Board since the 14th SIRM resulting on one hand in an expanded Scientific Committee which meanwhile consists of 31 members from 13 different European countries and on the other hand in the new name “European Conference on Rotordynamics”. This new international profile has also been emphasized by participants of the 15th SIRM coming from 17 different countries out of three continents. We experienced a vital discussion and dialogue between industry and academia at the conference where roughly one third of the papers were presented by industry and two thirds by academia being an excellent basis to follow a bidirectional transfer what we call xchange at Technical University of Darmstadt. At this point we also want to give our special thanks to the eleven industry sponsors for their great support of the conference. On behalf of the Darmstadt Local Committee I welcome you to read the papers of the 15th SIRM giving you further insight into the topics and presentations
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