4,632 research outputs found

    Computing Petaflops over Terabytes of Data: The Case of Genome-Wide Association Studies

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    In many scientific and engineering applications, one has to solve not one but a sequence of instances of the same problem. Often times, the problems in the sequence are linked in a way that allows intermediate results to be reused. A characteristic example for this class of applications is given by the Genome-Wide Association Studies (GWAS), a widely spread tool in computational biology. GWAS entails the solution of up to trillions (101210^{12}) of correlated generalized least-squares problems, posing a daunting challenge: the performance of petaflops (101510^{15} floating-point operations) over terabytes of data. In this paper, we design an algorithm for performing GWAS on multi-core architectures. This is accomplished in three steps. First, we show how to exploit the relation among successive problems, thus reducing the overall computational complexity. Then, through an analysis of the required data transfers, we identify how to eliminate any overhead due to input/output operations. Finally, we study how to decompose computation into tasks to be distributed among the available cores, to attain high performance and scalability. With our algorithm, a GWAS that currently requires the use of a supercomputer may now be performed in matter of hours on a single multi-core node. The discussion centers around the methodology to develop the algorithm rather than the specific application. We believe the paper contributes valuable guidelines of general applicability for computational scientists on how to develop and optimize numerical algorithms

    Faster Mutation Analysis via Equivalence Modulo States

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    Mutation analysis has many applications, such as asserting the quality of test suites and localizing faults. One important bottleneck of mutation analysis is scalability. The latest work explores the possibility of reducing the redundant execution via split-stream execution. However, split-stream execution is only able to remove redundant execution before the first mutated statement. In this paper we try to also reduce some of the redundant execution after the execution of the first mutated statement. We observe that, although many mutated statements are not equivalent, the execution result of those mutated statements may still be equivalent to the result of the original statement. In other words, the statements are equivalent modulo the current state. In this paper we propose a fast mutation analysis approach, AccMut. AccMut automatically detects the equivalence modulo states among a statement and its mutations, then groups the statements into equivalence classes modulo states, and uses only one process to represent each class. In this way, we can significantly reduce the number of split processes. Our experiments show that our approach can further accelerate mutation analysis on top of split-stream execution with a speedup of 2.56x on average.Comment: Submitted to conferenc
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