Tumour grading and discrimination based on class assignment and quantitative texture analysis techniques

Medical imaging represents the utilisation of technology in biology for the purpose of noninvasively revealing the internal structure of the organs of the human body. It is a way to improve the quality of the patient's life through a more precise and rapid diagnosis, and with limited side-effects, leading to an effective overall treatment procedure. The main objective of this thesis is to propose novel tumour discrimination techniques that cover both micro and macro-scale textures encountered in computed tomography (CI') and digital microscopy (DM) modalities, respectively. Image texture can provide significant information on the (ab)normality of tissue, and this thesis expands this idea to tumour texture grading and classification. The fractal dimension (FO) as a texture measure was applied to contrast enhanced CT lung tumour images in an aim to improve tumour grading accuracy from conventional CI' modality, and quantitative performance analysis showed an accuracy of 83.30% in distinguishing between advanced (aggressive) and early stage (non-aggressive) malignant tumours. A different approach was adopted for subtype discrimination of brain tumour OM images via a set of statistical and model-based texture analysis algorithms. The combined Gaussian Markov random field and run-length matrix texture measures outperformed all other combinations, achieving an overall class assignment classification accuracy of 92.50%. Also two new histopathological multi resolution approaches based on applying the FO as the best bases selection for discrete wavelet packet transform, and when fused with the Gabor filters' energy output improved the accuracy to 91.25% and 95.00%, respectively. While noise is quite common in all medical imaging modalities, the impact of noise on the applied texture measures was assessed as well. The developed lung and brain texture analysis techniques can improve the physician's ability to detect and analyse pathologies leading for a more reliable diagnosis and treatment of disease

Hierarchical Multiple Markov Chain Model for Unsupervised Texture Segmentation

International audienceIn this work, we present a novel multiscale texture model, and a related algorithm for the unsupervised segmentation of color images. Elementary textures are characterized by their spatial interactions with neighboring regions along selected directions. Such interactions are modeled in turn by means of a set of Markov chains, one for each direction, whose parameters are collected in a feature vector that synthetically describes the texture. Based on the feature vectors, the texture are then recursively merged, giving rise to larger and more complex textures, which appear at different scales of observation: accordingly, the model is named Hierarchical Multiple Markov Chain (H-MMC). The Texture Fragmentation and Reconstruction (TFR) algorithm, addresses the unsupervised segmen- tation problem based on the H-MMC model. The “fragmentation” step allows one to find the elementary textures of the model, while the “reconstruction” step defines the hierarchical image segmentation based on a probabilistic measure (texture score) which takes into account both region scale and inter-region interactions. The performance of the proposed method was assessed through the Prague segmentation benchmark, based on mosaics of real natural textures, and also tested on real-world natural and remote sensing images

Multispectral texture synthesis

Synthesizing texture involves the ordering of pixels in a 2D arrangement so as to display certain known spatial correlations, generally as described by a sample texture. In an abstract sense, these pixels could be gray-scale values, RGB color values, or entire spectral curves. The focus of this work is to develop a practical synthesis framework that maintains this abstract view while synthesizing texture with high spectral dimension, effectively achieving spectral invariance. The principle idea is to use a single monochrome texture synthesis step to capture the spatial information in a multispectral texture. The first step is to use a global color space transform to condense the spatial information in a sample texture into a principle luminance channel. Then, a monochrome texture synthesis step generates the corresponding principle band in the synthetic texture. This spatial information is then used to condition the generation of spectral information. A number of variants of this general approach are introduced. The first uses a multiresolution transform to decompose the spatial information in the principle band into an equivalent scale/space representation. This information is encapsulated into a set of low order statistical constraints that are used to iteratively coerce white noise into the desired texture. The residual spectral information is then generated using a non-parametric Markov Ran dom field model (MRF). The remaining variants use a non-parametric MRF to generate the spatial and spectral components simultaneously. In this ap proach, multispectral texture is grown from a seed region by sampling from the set of nearest neighbors in the sample texture as identified by a template matching procedure in the principle band. The effectiveness of both algorithms is demonstrated on a number of texture examples ranging from greyscale to RGB textures, as well as 16, 22, 32 and 63 band spectral images. In addition to the standard visual test that predominates the literature, effort is made to quantify the accuracy of the synthesis using informative and effective metrics. These include first and second order statistical comparisons as well as statistical divergence tests

Role based behavior analysis

Tese de mestrado, Segurança Informática, Universidade de Lisboa, Faculdade de Ciências, 2009Nos nossos dias, o sucesso de uma empresa depende da sua agilidade e capacidade de se adaptar a condições que se alteram rapidamente. Dois requisitos para esse sucesso são trabalhadores proactivos e uma infra-estrutura ágil de Tecnologias de Informacão/Sistemas de Informação (TI/SI) que os consiga suportar. No entanto, isto nem sempre sucede. Os requisitos dos utilizadores ao nível da rede podem nao ser completamente conhecidos, o que causa atrasos nas mudanças de local e reorganizações. Além disso, se não houver um conhecimento preciso dos requisitos, a infraestrutura de TI/SI poderá ser utilizada de forma ineficiente, com excessos em algumas áreas e deficiências noutras. Finalmente, incentivar a proactividade não implica acesso completo e sem restrições, uma vez que pode deixar os sistemas vulneráveis a ameaças externas e internas. O objectivo do trabalho descrito nesta tese é desenvolver um sistema que consiga caracterizar o comportamento dos utilizadores do ponto de vista da rede. Propomos uma arquitectura de sistema modular para extrair informação de fluxos de rede etiquetados. O processo é iniciado com a criação de perfis de utilizador a partir da sua informação de fluxos de rede. Depois, perfis com características semelhantes são agrupados automaticamente, originando perfis de grupo. Finalmente, os perfis individuais são comprados com os perfis de grupo, e os que diferem significativamente são marcados como anomalias para análise detalhada posterior. Considerando esta arquitectura, propomos um modelo para descrever o comportamento de rede dos utilizadores e dos grupos. Propomos ainda métodos de visualização que permitem inspeccionar rapidamente toda a informação contida no modelo. O sistema e modelo foram avaliados utilizando um conjunto de dados reais obtidos de um operador de telecomunicações. Os resultados confirmam que os grupos projectam com precisão comportamento semelhante. Além disso, as anomalias foram as esperadas, considerando a população subjacente. Com a informação que este sistema consegue extrair dos dados em bruto, as necessidades de rede dos utilizadores podem sem supridas mais eficazmente, os utilizadores suspeitos são assinalados para posterior análise, conferindo uma vantagem competitiva a qualquer empresa que use este sistema.In our days, the success of a corporation hinges on its agility and ability to adapt to fast changing conditions. Proactive workers and an agile IT/IS infrastructure that can support them is a requirement for this success. Unfortunately, this is not always the case. The user’s network requirements may not be fully understood, which slows down relocation and reorganization. Also, if there is no grasp on the real requirements, the IT/IS infrastructure may not be efficiently used, with waste in some areas and deficiencies in others. Finally, enabling proactivity does not mean full unrestricted access, since this may leave the systems vulnerable to outsider and insider threats. The purpose of the work described on this thesis is to develop a system that can characterize user network behavior. We propose a modular system architecture to extract information from tagged network flows. The system process begins by creating user profiles from their network flows’ information. Then, similar profiles are automatically grouped into clusters, creating role profiles. Finally, the individual profiles are compared against the roles, and the ones that differ significantly are flagged as anomalies for further inspection. Considering this architecture, we propose a model to describe user and role network behavior. We also propose visualization methods to quickly inspect all the information contained in the model. The system and model were evaluated using a real dataset from a large telecommunications operator. The results confirm that the roles accurately map similar behavior. The anomaly results were also expected, considering the underlying population. With the knowledge that the system can extract from the raw data, the users network needs can be better fulfilled, the anomalous users flagged for inspection, giving an edge in agility for any company that uses it