The Limits to Competition in the Jamaican Urban Bus Service.

In the context of best practice with regards to the market structure and organization of urban public transport over the last 30 years or so would reveal the popularity of a hybrid transport model, that is a model in which the public and the private sector share responsibilities for the delivery of the service. A more careful review would reveal an evolving consensus with respect to the optimal degree and form of government intervention in this hybrid model. We look at the Chilean model, which has had similar experiences to us in a similar time period to see if Jamaican policy makers can enhance our system, the JUTC (Jamaican Urban Transport System) by their experiences.

The Chawton House Experience - Augmenting the Grounds of a Historic Manor House

Museum research is a burgeoning area of research where ubiquitous computing has already made an impact in enhancing user experiences. The goal of the Chawton House project is to extend this work by introducing ubicomp not to a museum as such, but a historic English manor house and its grounds. This presents a number of novel challenges relating to the kinds of visitors, the nature of visits, the specific character of the estate, the creation of a persistent and evolving system, and the process of developing it together with Chawton House staff

Exploration of applying a theory-based user classification model to inform personalised content-based image retrieval system design

© ACM, 2016. This is the author's version of the work. It is posted here by permission of ACM for your personal use. Not for redistribution. The definitive version was published at http://dl.acm.org/citation.cfm?id=2903636To better understand users and create more personalised search experiences, a number of user models have been developed, usually based on different theories or empirical data study. After developing the user models, it is important to effectively utilise them in the design, development and evaluation of search systems to improve users’ overall search experiences. However there is a lack of research has been done on the utilisation of the user models especially theory-based models, because of the challenges on the utilization methodologies when applying the model to different search systems. This paper explores and states how to apply an Information Foraging Theory (IFT) based user classification model called ISE to effectively identify user’s search characteristics and create user groups, based on an empirically-driven methodology for content-based image retrieval (CBIR) systems and how the preferences of different user types inform the personalized design of the CBIR systems

MAIT cells come to the rescue in cancer immunotherapy?

Recent progress in immunobiology has led to the observation that, among cells classically categorized as the typical representatives of the adaptive immune system, i.e., T cells, some possess the phenotype of innate cells. Invariant T cells are characterized by T cell receptors recognizing a limited range of non-peptide antigens, presented only in the context of particular molecules. Mucosal-associated invariant T cells (MAIT cells) are an example of such unconventional cells. In humans, they constitute between 1% and 8% of the peripheral blood T lymphocytes and are further enriched in mucosal tissues, mesenteric lymph nodes, and liver, where they can account for even 40% of all the T cells. MAIT cells recognize antigens in the context of major histocompatibility complex class I-related protein (MR1). Upon activation, they instantly release pro-inflammatory cytokines and mediate cytolytic function towards bacterially infected cells. As such, they have been a rapidly evolving research topic not only in the field of infectious diseases but also in the context of many chronic inflammatory diseases and, more recently, in immuno-oncology. Novel findings suggest that MAIT cells function could also be modulated by endogenous ligands and drugs, making them an attractive target for therapeutic approaches. In this review, we summarize the current understanding of MAIT cell biology, their role in health and disease and discuss their future potential in cancer immunotherapy. This is discussed through the prism of knowledge and experiences with invariant natural killer T cells (iNKT)—another prominent unconventional T cell subset that shares many features with MAIT cells

Uptake of BIM and IPD within the UK AEC Industry: the evolving role of the architectural technologist

Building Information Modelling is not only a tool, but also the process of creation, maintenance, distribution and co-ordination of an integrated database that collaboratively stores 2D and 3D information, with embedded physical and functional data within a project-building model. The uptake of BIM within the UK Architecture, Engineering and Construction (AEC) industry has been slow since the 1980’s, but over recent years, adoptions have increased. The increased collaborative nature of BIM, external data sharing techniques and progressively complex building design, promotes requirements for design teams to coordinate and communicate more effectively to achieve project goals. To manage this collaboration, new or evolved job roles may emerge. This research examined the current use of BIM, Integrated Project Delivery (IPD) and collaborative working in the UK AEC industry and job roles that have evolved or been created to cater for them. Using semi-structured interviews the interviewees indicated while several of the key enablers of IPD were being used, IPD itself had not been fully adopted. BIM was being used with some success but improvements could be made. New job roles such as the BIM Engineer and BIM Coordinator had been seen in the industry and evidence that the Architectural Technologist (AT) role is evolving into a more multidisciplinary role; this reflects similar findings of recent research

Wave Function Ontology

I argue that the wave function ontology for quantum mechanics is an undesirable ontology. This ontology holds that the fundamental space in which entities evolve is not three-dimensional, but instead 3N-dimensional, where N is the number of particles standardly thought to exist in three-dimensional space. I show that the state of three-dimensional objects does not supervene on the state of objects in 3N-dimensional space. I also show that the only way to guarantee the existence of the appropriate mental states in the wave function ontology has undesirable metaphysical baggage: either mind/body dualism is true, or circumstances which we take to be logically possible turn out to be logically impossible