Ultra-Wideband CMOS Transceiver Front-End for Bio-Medical Radar Sensing

Since the Federal Communication Commission released the unlicensed 3.1-10.6 GHz frequency band for commercial use in early 2002, the ultra wideband (UWB) has developed from an emerging technology into a mainstream research area. The UWB technology, which utilizes wide spectrum, opens a new era of possibility for practical applications in radar sensing, one of which is the human vital sign monitoring. The aim of this thesis is to study and research the possibility of a new generation humanrespiration monitoring sensor using UWB radar technology and to develop a new prototype of UWB radar sensor for system-on-chip solutions in CMOS technology. In this thesis, a lowpower Gaussian impulse UWB mono-static radar transceiver architecture is presented. The UWB Gaussian pulse transmitter and receiver are implemented and fabricated using 90nm CMOS technology. Since the energy of low order Gaussian pulse is mostly condensed at lower frequency, in order to transmit the pulse in a very efficient way, higher order Gaussian derivative pulses are desired as the baseband signal. This motivates the advancement of the design into UWB high-order pulse transmitter. Both the Gaussian impulse UWB transmitter and Gaussian higher-order impulse UWB transmitter take the low-power and high-speed advantage of digital circuit to generate different waveforms. The measurement results are analyzed and discussed. This thesis also presents a low-power UWB mono-static radar transceiver architecture exploiting the full benefit of UWB bandwidth in radar sensing applications. The transceiver includes a full UWB band transmitter, an UWB receiver front-end, and an on-chip diplexer. The non-coherent UWB transmitter generates pulse modulated baseband signals at different carrier frequencies within the designated 3-10 GHz band using a digitally controlled pulse generator. The test shows the proposed radar transceiver can detect the human respiration pattern within 50 cm distance. The applications of this UWB radar sensing solution in commercialized standard CMOS technology include constant breathing pattern monitoring for gated radiation therapy, realtime monitoring of patients, and any other breathing monitoring. The research paves the way to wireless technology integration with health care and bio-sensor network

A 0.18µm CMOS UWB wireless transceiver for medical sensing applications

Recently, there is a new trend of demand of a biomedical device that can continuously monitor patient’s vital life index such as heart rate variability (HRV) and respiration rate. This desired device would be compact, wearable, wireless, networkable and low-power to enable proactive home monitoring of vital signs. This device should have a radar sensor portion and a wireless communication link all integrated in one small set. The promising technology that can satisfy these requirements is the impulse radio based Ultra-wideband (IR-UWB) technology. Since Federal Communications Commission (FCC) released the 3.1GHz-10.6GHz frequency band for UWB applications in 2002 [1], IR-UWB has received significant attention for applications in target positioning and wireless communications. IR-UWB employs extremely narrow Gaussian monocycle pulses or any other forms of short RF pulses to represent information. In this project, an integrated wireless UWB transceiver for the 3.1GHz-10.6GHz IR-UWB medical sensor was developed in the 0.18µm CMOS technology. This UWB transceiver can be employed for both radar sensing and communication purposes. The transceiver applies the On-Off Keying (OOK) modulation scheme to transmit short Gaussian pulse signals. The transmitter output power level is adjustable. The fully integrated UWB transceiver occupies a core area of 0.752mm^2 and the total die area of 1.274mm^2 with the pad ring inserted. The transceiver was simulated with overall power consumption of 40mW for radar sensing. The receiver is very sensitive to weak signals with a sensitivity of -73.01dBm. The average power of a single pulse is 9.8µW. The pulses are not posing any harm to human tissues. The sensing resolution and the target positioning precision are presumably sufficient for heart movement detection purpose in medical applications. This transceiver can also be used for high speed wireless data communications. The data transmission rate of 200 Mbps was achieved with an overall power consumption of 57mW. A combination of sensing and communications can be used to build a low power sensor

Ultra Wideband

Ultra wideband (UWB) has advanced and merged as a technology, and many more people are aware of the potential for this exciting technology. The current UWB field is changing rapidly with new techniques and ideas where several issues are involved in developing the systems. Among UWB system design, the UWB RF transceiver and UWB antenna are the key components. Recently, a considerable amount of researches has been devoted to the development of the UWB RF transceiver and antenna for its enabling high data transmission rates and low power consumption. Our book attempts to present current and emerging trends in-research and development of UWB systems as well as future expectations

Bio-Radar Applications for Remote Vital Signs Monitoring

Nowadays, most vital signs monitoring techniques used in a medical context and/or daily life routines require direct contact with skin, which can become uncomfortable or even impractical to be used regularly. Radar technology has been appointed as one of the most promising contactless tools to overcome these hurdles. However, there is a lack of studies that cover a comprehensive assessment of this technology when applied in real-world environments. This dissertation aims to study radar technology for remote vital signs monitoring, more specifically, in respiratory and heartbeat sensing. Two off-the-shelf radars, based on impulse radio ultra-wideband and frequency modu lated continuous wave technology, were customized to be used in a small proof of concept experiment with 10 healthy participants. Each subject was monitored with both radars at three different distances for two distinct conditions: breathing and voluntary apnea. Signals processing algorithms were developed to detect and estimate respiratory and heartbeat parameters, assessed using qualitative and quantitative methods. Concerning respiration, a minimum error of 1.6% was found when radar respiratory peaks signals were directly compared with their reference, whereas a minimum mean absolute error of 0.3 RPM was obtained for the respiration rate. Concerning heartbeats, their expression in radar signals was not as clear as the respiration ones, however a minimum mean absolute error of 1.8 BPM for heartbeat was achieved after applying a novel selective algorithm developed to validate if heart rate value was estimated with reliability. The results proved the potential for radars to be used in respiratory and heartbeat contactless sensing, showing that the employed methods can be already used in some mo tionless situations. Notwithstanding, further work is required to improve the developed algorithms in order to obtain more robust and accurate systems.Atualmente, a maioria das técnicas usadas para a monitorização de sinais vitais em contexto médicos e/ou diário requer contacto direto com a pele, o que poderá tornar-se incómodo ou até mesmo inviável em certas situações. A tecnologia radar tem vindo a ser apontada como uma das mais promissoras ferramentas para medição de sinais vitais à distância e sem contacto. Todavia, são necessários mais estudos que permitam avaliar esta tecnologia quando aplicada a situações mais reais. Esta dissertação tem como objetivo o estudo da tecnologia radar aplicada no contexto de medição remota de sinais vitais, mais concretamente, na medição de atividade respiratória e cardíaca. Dois aparelhos radar, baseados em tecnologia banda ultra larga por rádio de impulso e em tecnologia de onda continua modulada por frequência, foram configurados e usados numa prova de conceito com 10 participantes. Cada sujeito foi monitorizado com cada um dos radar em duas situações distintas: respirando e em apneia voluntária. Algorit mos de processamento de sinal foram desenvolvidos para detetar e estimar parâmetros respiratórios e cardíacos, avaliados através de métodos qualitativos e quantitativos. Em relação à respiração, o menor erro obtido foi de 1,6% quando os sinais de radar respiratórios foram comparados diretamente com os sinais de referência, enquanto que, um erro médio absoluto mínimo de 0,3 RPM foi obtido para a estimação da frequência respiratória via radar. A expressão cardíaca nos sinais radar não se revelou tão evidente como a respiratória, no entanto, um erro médio absoluto mínimo de 1,8 BPM foi obtido para a estimação da frequência cardíaca após a aplicação de um novo algoritmo seletivo, desenvolvido para validar a confiança dos valores obtidos. Os resultados obtidos provaram o potencial do uso de radares na medição de atividade respiratória e cardíaca sem contacto, sendo esta tecnologia viável de ser implementada em situações onde não existe muito movimento. Não obstante, os algoritmos desenvolvidos devem ser aperfeiçoados no futuro de forma a obter sistemas mais robustos e precisos

A MEMS BASED MICROWAVE PIXEL FOR UWB RADAR BASED 3-D DIAGNOSTIC IMAGING

A MEMS-based microwave Pixel has been developed for use with an Ultra-wideband (UWB) radar probe for high-resolution 3-D non-contact, non-ionizing tomographic diagnostic imaging of the thorax. In the proposed system, an UWB radar transmits a 400 ps duration pulse in the frequency range of 3.1 GHz to 5.1 GHz. The transmitted pulse penetrates through the tissues and is partially reflected at each tissue interface characterized by a complex permittivity change. A suitable microwave lens focuses the reflected wavefront on a 2-D array of MEMS-based microwave Pixels to illuminate each Pixel to a tiny 2-D section of the reflected wavefront. Each Pixel with a footprint area of 595 x 595 μm2 is designed to have 144 parallel connected microfabricated inductors, each with an inductance of 12.439 nH, and a single 150 μm×150 μm microfabricated deformable diaphragm based variable capacitor to generate a voltage which is the dielectric signature of the respective tissue section. A 2-D array of such Pixels can be used to generate a voltage map that corresponds to the dielectric property distribution of the target area. The high dielectric contrast between the healthy and diseased tissues, enable a high precision diagnostics of medical conditions in a non-invasive non-contact manner. This thesis presents the analytical design, 3-D finite element simulation results, and a fabrication process to realize the proposed microwave imaging Pixel. The proposed Pixel with total inductance of 86.329 pH and capacitance tuning range of 1.68:1, achieved a sensitivity of 4.5 aF/0.8 μA.m-1 to generate tomographic coronal imaging slices of human thorax deep upto 4.2 cm enabling a theoritical lateral resolution of 0.59 mm

Non-invasive blood glucose concentration level estimation accuracy using ultra-wide band and artificial intelligence

Diabetes becomes a rapidly increasing global epidemic and getting serious health concern worldwide. There is no remedy except systematic management to keep blood glucose level under control. To achieve that regular glucose level monitoring is a routine task for a patient. This involves collection of blood physically from body with some discomfort and measuring using some device. To overcome this disadvantages and distress, non-invasive blood glucose measurement system is in demand. This article presents an ultra-wide band (UWB) microwave imaging and artificial intelligence based prospective solution to detect blood glucose concentration level non-invasively (without physical blood). The system consists of a pair of small UWB biomedical planar antenna, UWB transceiver as hardware and an artificial neural network with signal acquisition and processing interface as software module. The UWB signal with center frequency of 4.7 GHz was transmitted through ear lobe and forward scattering signals were received from other side. Characteristics features of received signal were extracted for pattern recognition and detection through deep artificial neural network. The system exhibits around 88% accuracy to detect glucose concentration in blood plasma. Besides, it is affordable, safe, user friendly and can be used with comfort in near future

High-performance wireless interface for implant-to-air communications

Nous élaborons une interface cerveau-machine (ICM) entièrement sans fil afin de fournir un système de liaison directe entre le cerveau et les périphériques externes, permettant l’enregistrement et la stimulation du cerveau pour une utilisation permanente. Au cours de cette thèse, nous explorons la modélisation de canal, les antennes implantées et portables en tant que propagateurs appropriés pour cette application, la conception du nouveau système d’un émetteur-récepteur UWB implantable, la conception niveau système du circuit et sa mise en oeuvre par un procédé CMOS TSMC 0.18 um. En plus, en collaboration avec Université McGill, nous avons conçu un réseau de seize antennes pour une détection du cancer du sein à l’aide d’hyperfréquences. Notre première contribution calcule la caractérisation de canal de liaison sans fil UWB d’implant à l’air, l’absorption spécifique moyennée (ASAR), et les lignes directrices de la FCC sur la densité spectrale de puissance UWB transmis. La connaissance du comportement du canal est nécessaire pour déterminer la puissance maximale permise à 1) respecter les lignes directrices ANSI pour éviter des dommages aux tissus et 2) respecter les lignes directrices de la FCC sur les transmissions non autorisées. Nous avons recours à un modèle réaliste du canal biologique afin de concevoir les antennes pour l’émetteur implanté et le récepteur externe. Le placement des antennes est examiné avec deux scénarios contrastés ayant des contraintés de puissance. La performance du système au sein des tissus biologiques est examinée par l’intermédiaire des simulations et des expériences. Notre deuxième contribution est dédiée à la conception des antennes simples et à double polarisation pour les systèmes d’enregistrement neural sans fil à bande ultra-large en utilisant un modèle multicouches inhomogène de la tête humaine. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à l’implantation ; nous étudions des matériaux à la fois flexibles et rigides et examinons des compromis de performance. Les antennes proposées sont conçues pour fonctionner dans une plage de fréquence de 2-11 GHz (ayant S11-dessous de -10 dB) couvrant à la fois la bande 2.45 GHz (ISM) et la bande UWB 3.1-10.6 GHz. Des mesures confirment les résultats de simulation et montrent que les antennes flexibles ont peu de dégradation des performances en raison des effets de flexion (en termes de correspondance d’impédance). Finalement, une comparaison est réalisée entre quatre antennes implantables, couvrant la gamme 2-11 GHz : 1) une rigide, à la polarisation simple, 2) une rigide, à double polarisation, 3) une flexible, à simple polarisation et 4) une flexible, à double polarisation. Dans tous les cas une antenne rigide est utilisée à l’extérieur du corps, avec une polarisation appropriée. Plusieurs avantages ont été confirmés pour les antennes à la polarisation double : 1) une taille plus petite, 2) la sensibilité plus faible aux désalignements angulaires, et 3) une plus grande fidélité. Notre troisième contribution fournit la conception niveau système de l’architecture de communication sans fil pour les systèmes implantés qui stimulent simultanément les neurones et enregistrent les réponses de neurones. Cette architecture prend en charge un grand nombre d’électrodes (> 500), fournissant 100 Mb/s pour des signaux de stimulation de liaison descendante, et Gb/s pour les enregistrements de neurones de liaison montante. Nous proposons une architecture d’émetteur-récepteur qui partage une antenne ultra large bande, un émetteur-récepteur simplifié, travaillant en duplex intégral sur les deux bandes, et un nouveau formeur d’impulsions pour la liaison montante du Gb/s soutenant plusieurs formats de modulation. Nous présentons une démonstration expérimentale d’ex vivo de l’architecture en utilisant des composants discrets pour la réalisation les taux Gb/s en liaison montante. Une bonne performance de taux d’erreur de bit sur un canal biologique à 0,5, 1 et 2 Gb/s des débits de données pour la télémétrie de liaison montante (UWB) et 100 Mb/s pour la télémétrie en liaison descendante (bande 2.45 GHz) est atteinte. Notre quatrième contribution présente la conception au niveau du circuit d’un dispositif d’émission en duplex total qui est présentée dans notre troisième contribution. Ce dispositif d’émission en duplex total soutient les applications d’interfaçage neural multimodal et en haute densité (les canaux de stimulant et d’enregistrement) avec des débits de données asymétriques. L’émetteur (TX) et le récepteur (RX) partagent une seule antenne pour réduire la taille de l’implant. Le TX utilise impulse radio ultra-wide band (IR-UWB) basé sur une approche alliant des bords, et le RX utilise un nouveau 2.4 GHz récepteur on-off keying (OOK).Une bonne isolation (> 20 dB) entre le trajet TX et RX est mis en oeuvre 1) par mise en forme des impulsions transmises pour tomber dans le spectre UWB non réglementé (3.1-7 GHz), et 2) par un filtrage espace-efficace du spectre de liaison descendante OOK dans un amplificateur à faible bruit RX. L’émetteur UWB 3.1-7 GHz peut utiliser soit OOK soit la modulation numérique binaire à déplacement de phase (BPSK). Le FDT proposé offre une double bande avec un taux de données de liaison montante de 500 Mbps TX et un taux de données de liaison descendante de 100 Mb/s RX, et il est entièrement en conformité avec les standards TSMC 0.18 um CMOS dans un volume total de 0,8 mm2. Ainsi, la mesure de consommation d’énergie totale en mode full duplex est de 10,4 mW (5 mW à 100 Mb/s pour RX, et de 5,4 mW à 500 Mb/s ou 10,8 PJ / bits pour TX). Notre cinquième contribution est une collaboration avec l’Université McGill dans laquelle nous concevons des antennes simples et à double polarisation pour les systèmes de détection du cancer du sein à l’aide d’hyperfréquences sans fil en utilisant un modèle multi-couche et inhomogène du sein humain. Les antennes fabriquées à partir de matériaux flexibles sont plus facilement adaptées à des applications portables. Les antennes flexibles miniaturisées monopôles et spirales sur un 50 um Kapton polyimide sont conçus, en utilisant high frequency structure simulator (HFSS), à être en contact avec des tissus biologiques du sein. Les antennes proposées sont conçues pour fonctionner dans une gamme de fréquences de 2 à 4 GHz. Les mesures montrent que les antennes flexibles ont une bonne adaptation d’impédance dans les différentes positions sur le sein. De Plus, deux antennes à bande ultralarge flexibles 4 × 4 (simple et à double polarisation), dans un format similaire à celui d’un soutien-gorge, ont été développés pour un système de détection du cancer du sein basé sur le radar.We are working on a fully wireless brain-machine-interface to provide a communication link between the brain and external devices, enabling recording and stimulating the brain for permanent usage. In this thesis we explore channel modeling, implanted and wearable antennas as suitable propagators for this application, system level design of an implantable UWB transceiver, and circuit level design and implementing it by TSMC 0.18 um CMOS process. Also, in a collaboration project with McGill University, we designed a flexible sixteen antenna array for microwave breast cancer detection. Our first contribution calculates channel characteristics of implant-to-air UWB wireless link, average specific absorption rate (ASAR), and FCC guidelines on transmitted UWB power spectral density. Knowledge of channel behavior is required to determine the maximum allowable power to 1) respect ANSI guidelines for avoiding tissue damage and 2) respect FCC guidelines on unlicensed transmissions. We utilize a realistic model of the biological channel to inform the design of antennas for the implanted transmitter and the external receiver. Antennas placement is examined under two scenarios having contrasting power constraints. Performance of the system within the biological tissues is examined via simulations and experiments. Our second contribution deals with designing single and dual-polarization antennas for wireless ultra-wideband neural recording systems using an inhomogeneous multi-layer model of the human head. Antennas made from flexible materials are more easily adapted to implantation; we investigate both flexible and rigid materials and examine performance trade-offs. The proposed antennas are designed to operate in a frequency range of 2–11 GHz (having S11 below -10 dB) covering both the 2.45 GHz (ISM) band and the 3.1–10.6 GHz UWB band. Measurements confirm simulation results showing flexible antennas have little performance degradation due to bending effects (in terms of impedance matching). Finally, a comparison is made of four implantable antennas covering the 2-11 GHz range: 1) rigid, single polarization, 2) rigid, dual polarization, 3) flexible, single polarization and 4) flexible, dual polarization. In all cases a rigid antenna is used outside the body, with an appropriate polarization. Several advantages were confirmed for dual polarization antennas: 1) smaller size, 2) lower sensitivity to angular misalignments, and 3) higher fidelity. Our third contribution provides system level design of wireless communication architecture for implanted systems that simultaneously stimulate neurons and record neural responses. This architecture supports large numbers of electrodes (> 500), providing 100 Mb/s for the downlink of stimulation signals, and Gb/s for the uplink neural recordings. We propose a transceiver architecture that shares one ultra-wideband antenna, a streamlined transceiver working at full-duplex on both bands, and a novel pulse shaper for the Gb/s uplink supporting several modulation formats. We present an ex-vivo experimental demonstration of the architecture using discrete components achieving Gb/s uplink rates. Good bit error rate performance over a biological channel at 0.5, 1, and 2 Gbps data rates for uplink telemetry (UWB) and 100 Mbps for downlink telemetry (2.45 GHz band) is achieved. Our fourth contribution presents circuit level design of the novel full-duplex transceiver (FDT) which is presented in our third contribution. This full-duplex transceiver supports high-density and multimodal neural interfacing applications (high-channel count stimulating and recording) with asymmetric data rates. The transmitter (TX) and receiver (RX) share a single antenna to reduce implant size. The TX uses impulse radio ultra-wide band (IR-UWB) based on an edge combining approach, and the RX uses a novel 2.4-GHz on-off keying (OOK) receiver. Proper isolation (> 20 dB) between the TX and RX path is implemented 1) by shaping the transmitted pulses to fall within the unregulated UWB spectrum (3.1-7 GHz), and 2) by spaceefficient filtering (avoiding a circulator or diplexer) of the downlink OOK spectrum in the RX low-noise amplifier. The UWB 3.1-7 GHz transmitter can use either OOK or binary phase shift keying (BPSK) modulation schemes. The proposed FDT provides dual band 500-Mbps TX uplink data rate and 100 Mbps RX downlink data rate, and it is fully integrated into standard TSMC 0.18 um CMOS within a total size of 0.8 mm2. The total measured power consumption is 10.4 mW in full duplex mode (5 mW at 100 Mbps for RX, and 5.4 mW at 500 Mbps or 10.8 pJ/bit for TX). Our fifth contribution is a collaboration project with McGill University which we design single and dual-polarization antennas for wireless ultra-wideband breast cancer detection systems using an inhomogeneous multi-layer model of the human breast. Antennas made from flexible materials are more easily adapted to wearable applications. Miniaturized flexible monopole and spiral antennas on a 50 um Kapton polyimide are designed, using a high frequency structure simulator (HFSS), to be in contact with biological breast tissues. The proposed antennas are designed to operate in a frequency range of 2–4 GHz (with reflection coefficient (S11) below -10 dB). Measurements show that the flexible antennas have good impedance matching while in different positions with different curvature around the breast. Furthermore, two flexible conformal 4×4 ultra-wideband antenna arrays (single and dual polarization), in a format similar to that of a bra, were developed for a radar-based breast cancer detection system

Antennas and Propagation Aspects for Emerging Wireless Communication Technologies

The increasing demand for high data rate applications and the delivery of zero-latency multimedia content drives technological evolutions towards the design and implementation of next-generation broadband wireless networks. In this context, various novel technologies have been introduced, such as millimeter wave (mmWave) transmission, massive multiple input multiple output (MIMO) systems, and non-orthogonal multiple access (NOMA) schemes in order to support the vision of fifth generation (5G) wireless cellular networks. The introduction of these technologies, however, is inextricably connected with a holistic redesign of the current transceiver structures, as well as the network architecture reconfiguration. To this end, ultra-dense network deployment along with distributed massive MIMO technologies and intermediate relay nodes have been proposed, among others, in order to ensure an improved quality of services to all mobile users. In the same framework, the design and evaluation of novel antenna configurations able to support wideband applications is of utmost importance for 5G context support. Furthermore, in order to design reliable 5G systems, the channel characterization in these frequencies and in the complex propagation environments cannot be ignored because it plays a significant role. In this Special Issue, fourteen papers are published, covering various aspects of novel antenna designs for broadband applications, propagation models at mmWave bands, the deployment of NOMA techniques, radio network planning for 5G networks, and multi-beam antenna technologies for 5G wireless communications

Body-centric Wireless Hospital Patient Monitoring Networks using Body-contoured Flexible Antennas

This paper presents empirical results from a measurement campaign to investigate futuristic body-centric medical mesh networks for a hospitalized patient using flexible body-contouring antennas. It studies path loss in a medical environment (in a hospital bed in an open hospital ward) for UWB and four narrowband schemes concurrently. It firstly investigates the antenna contouring effects due to mounting the flexible antennas on various body surfaces, then uses statistical analysis to explore optimal body locations for a master node to inform allocation of processing power (assuming point-to-point link from other nodes). Results indicated how the most suitable body location varies depending on the posture and frequency scheme used. Also investigated are best route selections for multi-hop mesh network topologies for opportunistic networking for each of the presented postures and frequencies; this reveals how less hops were required to navigate around the narrowband network compared to UWB which effectively reduces required processing power and data traffic. Understanding how disparate body-centric medical devices communicate with one another in a body-mesh network is instrumental to the strategic and informed development of next generation healthcare patient monitoring solutions