34,213 research outputs found

    A Critical Scan of Four Key Topics for the Philanthropic Sector: A study by the Rockefeller Foundation and Accenture Development Partnerships

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    The study aims to identify problem areas in the developing and developed world, as well as areas of dynamism and convergence that will, over the next five to 10 years, present opportunities to make a greater impact in the development sector. The study, which made use of a consultative process, investigates four key topics central to human wellbeing. These are: natural ecosystems, health, livelihoods, and urban environments. In each of the four identified topic areas there is a greater need to foster innovation and shift paradigms in order to expand opportunity for the vulnerable and those living in poverty, and strengthen their resilience

    Integrating the landscape epidemiology and genetics of RNA viruses: rabies in domestic dogs as a model

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    Landscape epidemiology and landscape genetics combine advances in molecular techniques, spatial analyses and epidemiological models to generate a more real-world understanding of infectious disease dynamics and provide powerful new tools for the study of RNA viruses. Using dog rabies as a model we have identified how key questions regarding viral spread and persistence can be addressed using a combination of these techniques. In contrast to wildlife rabies, investigations into the landscape epidemiology of domestic dog rabies requires more detailed assessment of the role of humans in disease spread, including the incorporation of anthropogenic landscape features, human movements and socio-cultural factors into spatial models. In particular, identifying and quantifying the influence of anthropogenic features on pathogen spread and measuring the permeability of dispersal barriers are important considerations for planning control strategies, and may differ according to cultural, social and geographical variation across countries or continents. Challenges for dog rabies research include the development of metapopulation models and transmission networks using genetic information to uncover potential source/sink dynamics and identify the main routes of viral dissemination. Information generated from a landscape genetics approach will facilitate spatially strategic control programmes that accommodate for heterogeneities in the landscape and therefore utilise resources in the most cost-effective way. This can include the efficient placement of vaccine barriers, surveillance points and adaptive management for large-scale control programmes
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