Three-Dimensional Exact Legendre Moment Invariants For Amphetamine-Type Stimulants Molecular Structure Representation

The abuse of amphetamine-type stimulants (ATS) drugs has become a global,harrowing social problem.The technical limitations of the current test kits to detect new brand of ATS drugs present a challenge to national law enforcement authorities and scientific staff of forensic laboratories.Meanwhile,new molecular imaging devices which allowed mankind to characterize the physical three-dimensional (3D) molecular structure have been recently introduced,and it can be used to remedy the limitations of existing drug test kits.Thus,a new type of 3D molecular structure representation technique,or molecular descriptors,should be developed to cater the 3D molecular structure acquired physically using these molecular imaging devices.One of the image processing methods to represent a 3D image is 3D moments and moment invariants. However,there are problems exhibited by the existing 3D moments and moment invariants.Therefore,it is necessary to propose a new 3D moment invariants which is free from these problems.This study compares various 3D moments and identified 3D Legendre moments as the best moments to construct 3D moment invariants,namely 3D exact Legendre moment invariants (3D ELMI),which is used to represent the 3D molecular structure of ATS drugs.Since the 3D molecular structure of ATS drugs dataset obtained using molecular imaging devices are currently unavailable,this study acquired the 3D molecular structure of ATS drugs data from United Nations Office of Drug and Crime (UNODC) and pihkal.info database instead.The proposed technique was compared to the existing 3D moment invariants and molecular descriptors techniques in terms of processing time,memory consumption,single instance invariance,intra- and inter-class variance,and classification accuracy.The comparative study conducted found that 3D ELMI performs better than the existing 3D moment invariants,such as 3D geometric moment invariants (3D GMI),3D Gaussian–Hermite moment invariants (3D GHMI),and 3D Zernike descriptors (3D ZD).The satisfactory performance of 3D ELMI is attributed to numerous factors,such as the quality of the 3D Legendre,exact computation of the 3D Legendre,and the novelty of the proposed invariants techniques.The proposed technique was also compared to existing 3D molecular descriptors,for example weighted holistic invariants molecular (WHIM),geometry,topology,and atom weights assembly (GETAWAY),radial distribution function (RDF),and 3D molecule representation of structure based on electron diffraction (3D-MoRSE) descriptors.Despite 3D ELMI is capable to overcome the limitations of existing 3D molecular descriptors which depends on 3D molecular structure model instead of physical molecular structure obtained from molecular imaging devices,the test reveals 3D ELMI is not as good as these techniques,primarily due to the substantial number of features produced by the proposed technique.Nevertheless,the promising applicability and the unique approach of the proposed technique to represent the 3D molecular structure of ATS drugs has been demonstrated and worth to receive further exploration in the future works

Image-Based Force Estimation and Haptic Rendering For Robot-Assisted Cardiovascular Intervention

Clinical studies have indicated that the loss of haptic perception is the prime limitation of robot-assisted cardiovascular intervention technology, hindering its global adoption. It causes compromised situational awareness for the surgeon during the intervention and may lead to health risks for the patients. This doctoral research was aimed at developing technology for addressing the limitation of the robot-assisted intervention technology in the provision of haptic feedback. The literature review showed that sensor-free force estimation (haptic cue) on endovascular devices, intuitive surgeon interface design, and haptic rendering within the surgeon interface were the major knowledge gaps. For sensor-free force estimation, first, an image-based force estimation methods based on inverse finite-element methods (iFEM) was developed and validated. Next, to address the limitation of the iFEM method in real-time performance, an inverse Cosserat rod model (iCORD) with a computationally efficient solution for endovascular devices was developed and validated. Afterward, the iCORD was adopted for analytical tip force estimation on steerable catheters. The experimental studies confirmed the accuracy and real-time performance of the iCORD for sensor-free force estimation. Afterward, a wearable drift-free rotation measurement device (MiCarp) was developed to facilitate the design of an intuitive surgeon interface by decoupling the rotation measurement from the insertion measurement. The validation studies showed that MiCarp had a superior performance for spatial rotation measurement compared to other modalities. In the end, a novel haptic feedback system based on smart magnetoelastic elastomers was developed, analytically modeled, and experimentally validated. The proposed haptics-enabled surgeon module had an unbounded workspace for interventional tasks and provided an intuitive interface. Experimental validation, at component and system levels, confirmed the usability of the proposed methods for robot-assisted intervention systems

Role of Computational Fluid Dynamics in the Analysis of Haemodynamic and Morphological Characteristics of Intracranial Aneurysms

Aneurysmal subarachnoid hemorrhage (SAH) carries a high morbidity and mortality. The current protocols used to treat the unruptured Intracranial Aneurysms (IAs) are inadequate underscoring the need of finding new descriptors. As demonstrated by the studies performed in this manuscript, haemodynamics plays an important role in the aetiopathogenesis of IAs. An evaluation of haemodynamic indices can provide a useful alternative to predict the behavior of an unruptured IA at an early stage. Studies performed by me demonstrate that Computational Fluid Dynamics (CFD) can be used successfully to predict haemodynamic indices where detailed in vivo measurement of haemodynamic flow variables is not possible owing to technical limitations. European Commission funded Project @neurIST was the first project of it’s kind that brought together a number of multidisciplinary professionals from 32 European institutions and made possible development of state-of-the-art tools for personalised risk assessment and treatment IAs using CFD. These tools have been constantly improved and amended in the light of feedback gathered from their controlled exposures conducted world over, as described in the manuscript. However, need of a well-designed Randomized Controlled Trial in this context cannot be overemphasized, before these tools can be accepted by clinicians and patients. In my study on the validation of different concepts used in CFD, I demonstrated that there is no added advantage of complex Womersley-flow-profile over the much simpler plug-flow profile. One of my studies on initiation and rupture of IAs showed that the haemodynamic patterns of IAs during these two phases are significantly different with values of supra-physiological Wall Shear Stress (WSS) being higher in initiation while lower in rupture phase. I also investigated the effects of pharmacological agents on the aetiopathogenesis of IAs and found that heparin induces significant derangements in the haemodynamics of both, pre-aneurysmal as well as ruptured IA. I propose that heparin (and its derivatives) can, on the one hand may facilitate the rupture of existing IAs, on the other hand they may suppress the formation of new IAs. I have also found significant differences in the results using patient-specific vs. Modeled Boundary Conditions and showed that the 1D circulation model adopted by @neurIST performs better than other approaches found in the literature. I also proposed a novel mechanism of increase in Blood Viscosity leading to high WSS as one of the important underlying mechanisms responsible for the increased incidence of IA formation in smokers and hypertensive patients. In my study on patients with pre-existing Coarctation of Aorta (CoA) and Intracranial Aneurysms, I demonstrated that the cerebral flow-rates in CoA patients were significantly higher when compared to average flow-rates in healthy population. It was also seen that the values and the area affected by supraphysiological WSS (>15Pa) were exponentially higher in patients with CoA indicating the possible role of increased haemodynamic WSS secondary to the increased flow-rates playing an important role in the pathogenesis and rupture of IAs in CoA patients

The anthropometric, environmental and genetic determinants of right ventricular structure and function

BACKGROUND Measures of right ventricular (RV) structure and function have significant prognostic value. The right ventricle is currently assessed by global measures, or point surrogates, which are insensitive to regional and directional changes. We aim to create a high-resolution three-dimensional RV model to improve understanding of its structural and functional determinants. These may be particularly of interest in pulmonary hypertension (PH), a condition in which RV function and outcome are strongly linked. PURPOSE To investigate the feasibility and additional benefit of applying three-dimensional phenotyping and contemporary statistical and genetic approaches to large patient populations. METHODS Healthy subjects and incident PH patients were prospectively recruited. Using a semi-automated atlas-based segmentation algorithm, 3D models characterising RV wall position and displacement were developed, validated and compared with anthropometric, physiological and genetic influences. Statistical techniques were adapted from other high-dimensional approaches to deal with the problems of multiple testing, contiguity, sparsity and computational burden. RESULTS 1527 healthy subjects successfully completed high-resolution 3D CMR and automated segmentation. Of these, 927 subjects underwent next-generation sequencing of the sarcomeric gene titin and 947 subjects completed genotyping of common variants for genome-wide association study. 405 incident PH patients were recruited, of whom 256 completed phenotyping. 3D modelling demonstrated significant reductions in sample size compared to two-dimensional approaches. 3D analysis demonstrated that RV basal-freewall function reflects global functional changes most accurately and that a similar region in PH patients provides stronger survival prediction than all anthropometric, haemodynamic and functional markers. Vascular stiffness, titin truncating variants and common variants may also contribute to changes in RV structure and function. CONCLUSIONS High-resolution phenotyping coupled with computational analysis methods can improve insights into the determinants of RV structure and function in both healthy subjects and PH patients. Large, population-based approaches offer physiological insights relevant to clinical care in selected patient groups.Open Acces

Proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress

Published proceedings of the 2018 Canadian Society for Mechanical Engineering (CSME) International Congress, hosted by York University, 27-30 May 2018

Programming Languages and Systems

This open access book constitutes the proceedings of the 30th European Symposium on Programming, ESOP 2021, which was held during March 27 until April 1, 2021, as part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2021. The conference was planned to take place in Luxembourg and changed to an online format due to the COVID-19 pandemic. The 24 papers included in this volume were carefully reviewed and selected from 79 submissions. They deal with fundamental issues in the specification, design, analysis, and implementation of programming languages and systems

Social work with airports passengers

Social work at the airport is in to offer to passengers social services. The main methodological position is that people are under stress, which characterized by a particular set of characteristics in appearance and behavior. In such circumstances passenger attracts in his actions some attention. Only person whom he trusts can help him with the documents or psychologically