Reconstructing evolving signalling networks by hidden Markov nested effects models

Inferring time-varying networks is important to understand the development and evolution of interactions over time. However, the vast majority of currently used models assume direct measurements of node states, which are often difficult to obtain, especially in fields like cell biology, where perturbation experiments often only provide indirect information of network structure. Here we propose hidden Markov nested effects models (HM-NEMs) to model the evolving network by a Markov chain on a state space of signalling networks, which are derived from nested effects models (NEMs) of indirect perturbation data. To infer the hidden network evolution and unknown parameter, a Gibbs sampler is developed, in which sampling network structure is facilitated by a novel structural Metropolis–Hastings algorithm. We demonstrate the potential of HM-NEMs by simulations on synthetic time-series perturbation data. We also show the applicability of HM-NEMs in two real biological case studies, in one capturing dynamic crosstalk during the progression of neutrophil polarisation, and in the other inferring an evolving network underlying early differentiation of mouse embryonic stem cells.This is the final published manuscript, originally published by The Annals of Applied Statistics here: http://projecteuclid.org/euclid.aoas/1396966294

Developing and applying heterogeneous phylogenetic models with XRate

Modeling sequence evolution on phylogenetic trees is a useful technique in computational biology. Especially powerful are models which take account of the heterogeneous nature of sequence evolution according to the "grammar" of the encoded gene features. However, beyond a modest level of model complexity, manual coding of models becomes prohibitively labor-intensive. We demonstrate, via a set of case studies, the new built-in model-prototyping capabilities of XRate (macros and Scheme extensions). These features allow rapid implementation of phylogenetic models which would have previously been far more labor-intensive. XRate's new capabilities for lineage-specific models, ancestral sequence reconstruction, and improved annotation output are also discussed. XRate's flexible model-specification capabilities and computational efficiency make it well-suited to developing and prototyping phylogenetic grammar models. XRate is available as part of the DART software package: http://biowiki.org/DART .Comment: 34 pages, 3 figures, glossary of XRate model terminolog

Quantile and expectile copula-based hidden Markov regression models for the analysis of the cryptocurrency market

The role of cryptocurrencies within the financial systems has been expanding rapidly in recent years among investors and institutions. It is therefore crucial to investigate the phenomena and develop statistical methods able to capture their interrelationships, the links with other global systems, and, at the same time, the serial heterogeneity. For these reasons, this paper introduces hidden Markov regression models for jointly estimating quantiles and expectiles of cryptocurrency returns using regime-switching copulas. The proposed approach allows us to focus on extreme returns and describe their temporal evolution by introducing time-dependent coefficients evolving according to a latent Markov chain. Moreover to model their time-varying dependence structure, we consider elliptical copula functions defined by state-specific parameters. Maximum likelihood estimates are obtained via an Expectation-Maximization algorithm. The empirical analysis investigates the relationship between daily returns of five cryptocurrencies and major world market indices.Comment: 35 pages, 6 figures. arXiv admin note: text overlap with arXiv:2301.0972

Stochastic Block Transition Models for Dynamic Networks

There has been great interest in recent years on statistical models for dynamic networks. In this paper, I propose a stochastic block transition model (SBTM) for dynamic networks that is inspired by the well-known stochastic block model (SBM) for static networks and previous dynamic extensions of the SBM. Unlike most existing dynamic network models, it does not make a hidden Markov assumption on the edge-level dynamics, allowing the presence or absence of edges to directly influence future edge probabilities while retaining the interpretability of the SBM. I derive an approximate inference procedure for the SBTM and demonstrate that it is significantly better at reproducing durations of edges in real social network data.Comment: To appear in proceedings of AISTATS 201

Hidden Markov Models and their Application for Predicting Failure Events

We show how Markov mixed membership models (MMMM) can be used to predict the degradation of assets. We model the degradation path of individual assets, to predict overall failure rates. Instead of a separate distribution for each hidden state, we use hierarchical mixtures of distributions in the exponential family. In our approach the observation distribution of the states is a finite mixture distribution of a small set of (simpler) distributions shared across all states. Using tied-mixture observation distributions offers several advantages. The mixtures act as a regularization for typically very sparse problems, and they reduce the computational effort for the learning algorithm since there are fewer distributions to be found. Using shared mixtures enables sharing of statistical strength between the Markov states and thus transfer learning. We determine for individual assets the trade-off between the risk of failure and extended operating hours by combining a MMMM with a partially observable Markov decision process (POMDP) to dynamically optimize the policy for when and how to maintain the asset.Comment: Will be published in the proceedings of ICCS 2020; @Booklet{EasyChair:3183, author = {Paul Hofmann and Zaid Tashman}, title = {Hidden Markov Models and their Application for Predicting Failure Events}, howpublished = {EasyChair Preprint no. 3183}, year = {EasyChair, 2020}