954 research outputs found
ΠΠ°ΠΊΠ»Π°Π΄Π½ΡΠ΅ Π²ΠΈΡ ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΠ΅ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΠΈ: ΡΠΈΡΡΠ΅ΠΌΡ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ (ΠΎΠ±Π·ΠΎΡ)
Development of technical tools with improved metrological and operational characteristics is the actual problem of the eddy current testing. Ensuring the optimal distribution of the electromagnetic excitation field in the testing zone carries out confident detection of the defects and determination of their geometrical parameters by means of eddy current testing. The purpose of the work was to conduct an analysis of scientific and technical information in the field of eddy current testing to study of the use of electromagnetic excitation fields with a priori specified properties, as well as to generalize and systematize the accumulated experience and approaches to conduct theoretical research in this direction.A review of publications in the field of non-destructive electromagnetic testing devoted to the improvement of the excitation systems of eddy current flaw probes was carried out. The authors considered approaches in which a uniform distribution of the electromagnetic field on the control object surface was achieved by linear and non-linear optimal synthesis of excitation systems, provided the immobility of the probe relative to the testing object. Analysis of eddy current probe designs with a homogeneous excitation field created by circular, rectangular tangential and normal coils, as well as by creating a rotational excitation field was carried out. The authors studied designs of the excitation coils of probes with fields of complex configuration characterized by the original fractal geometry which can increase the probability of identifying defects that were not amenable to detection by classical probes.Studies that suggested the formation of optimal configuration fields in a given area using magnetic cores, field concentrators made of conductive materials and specially shaped screens were analyzed. The authors studied approaches to the implementation of the optimal synthesis of excitation systems of probes with uniform sensitivity in the testing zone using surrogate optimization for cases of moving testing objects taking into account the speed effect.The experience, as well as the results of theoretical studies devoted to the problem of designing eddy current probes with uniform sensitivity in the testing zone due to the uniform density distribution of the induced currents flowing in the object were generalized and systematized. As a result, the classification of probes on a number of features that characterize the excitation systems was proposed.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅ΠΉ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ² Ρ ΡΠ»ΡΡΡΠ΅Π½Π½ΡΠΌΠΈ ΠΌΠ΅ΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΡΠΊΡΠΏΠ»ΡΠ°ΡΠ°ΡΠΈΠΎΠ½Π½ΡΠΌΠΈ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΡΡΠΈΠΊΠ°ΠΌΠΈ. Π£Π²Π΅ΡΠ΅Π½Π½ΠΎΠ΅ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠ΅ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ² ΠΈ ΠΎΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΈΡ
Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΏΠ°ΡΠ°ΠΌΠ΅ΡΡΠΎΠ² ΡΡΠ΅Π΄ΡΡΠ²Π°ΠΌΠΈ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ ΠΎΡΡΡΠ΅ΡΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΡΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠ΅Π½ΠΈΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΡ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ Π² Π·ΠΎΠ½Π΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ Π·Π°ΠΊΠ»ΡΡΠ°Π»Π°ΡΡ Π² ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠΈ Π°Π½Π°Π»ΠΈΠ·Π° Π½Π°ΡΡΠ½ΠΎ-ΡΠ΅Ρ
Π½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΈ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π΄Π»Ρ ΠΈΠ·ΡΡΠ΅Π½ΠΈΡ ΡΠ²Π΅Π΄Π΅Π½ΠΈΠΉ ΠΎΠ± ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠΈ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΡΡ
ΠΏΠΎΠ»Π΅ΠΉ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ Ρ Π°ΠΏΡΠΈΠΎΡΠΈ Π·Π°Π΄Π°Π½Π½ΡΠΌΠΈ ΡΠ²ΠΎΠΉΡΡΠ²Π°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΎΠ±ΠΎΠ±ΡΠ΅Π½ΠΈΡ, ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΎΠΏΡΡΠ° ΠΈ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄ΠΎΠ² ΠΊ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ Π² Π΄Π°Π½Π½ΠΎΠΌ Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠΈ.ΠΡΠΎΠ²Π΅Π΄ΡΠ½ ΠΎΠ±Π·ΠΎΡ ΠΏΡΠ±Π»ΠΈΠΊΠ°ΡΠΈΠΉ Π² ΠΎΠ±Π»Π°ΡΡΠΈ Π½Π΅ΡΠ°Π·ΡΡΡΠ°ΡΡΠ΅Π³ΠΎ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, ΠΏΠΎΡΠ²ΡΡΡΠ½Π½ΡΡ
ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΡ ΡΠΈΡΡΠ΅ΠΌ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΡ
Π΄Π΅ΡΠ΅ΠΊΡΠΎΡΠΊΠΎΠΏΠΎΠ². Π Π°ΡΡΠΌΠΎΡΡΠ΅Π½Ρ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ, Π² ΠΊΠΎΡΠΎΡΡΡ
ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΠΎΠ΅ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΡΠ»Π΅ΠΊΡΡΠΎΠΌΠ°Π³Π½ΠΈΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π½Π° ΠΏΠΎΠ²Π΅ΡΡ
Π½ΠΎΡΡΠΈ ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Π΄ΠΎΡΡΠΈΠ³Π°Π΅ΡΡΡ Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΌ ΠΈ Π½Π΅Π»ΠΈΠ½Π΅ΠΉΠ½ΡΠΌ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΡΠΌ ΡΠΈΠ½ΡΠ΅Π·ΠΎΠΌ ΡΠΈΡΡΠ΅ΠΌ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠΈ ΡΡΠ»ΠΎΠ²ΠΈΠΈ Π½Π΅ΠΏΠΎΠ΄Π²ΠΈΠΆΠ½ΠΎΡΡΠΈ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Ρ ΠΎΡΠ½ΠΎΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΎΠ±ΡΠ΅ΠΊΡΠ° ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ. ΠΡΠΎΠ²Π΅Π΄ΡΠ½ Π°Π½Π°Π»ΠΈΠ· ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΉ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΡ
ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Ρ ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΡΠΌ ΠΏΠΎΠ»Π΅ΠΌ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ, ΡΠΎΠ·Π΄Π°Π½Π½ΡΠΌ ΠΊΡΡΠ³ΠΎΠ²ΡΠΌΠΈ, ΠΏΡΡΠΌΠΎΡΠ³ΠΎΠ»ΡΠ½ΡΠΌΠΈ ΡΠ°Π½Π³Π΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΈ Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΠΌΠΈ ΠΊΠ°ΡΡΡΠΊΠ°ΠΌΠΈ, Π° ΡΠ°ΠΊΠΆΠ΅ Π·Π° ΡΡΡΡ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ Π²ΡΠ°ΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ»Ρ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ. ΠΠ·ΡΡΠ°Π»ΠΈΡΡ ΠΊΠΎΠ½ΡΡΡΡΠΊΡΠΈΠΈ ΠΊΠ°ΡΡΡΠ΅ΠΊ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Ρ ΠΏΠΎΠ»ΡΠΌΠΈ ΡΠ»ΠΎΠΆΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠΈΠ³ΡΡΠ°ΡΠΈΠΈ, Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΠ΅ΡΡ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠΉ ΡΡΠ°ΠΊΡΠ°Π»ΡΠ½ΠΎΠΉ Π³Π΅ΠΎΠΌΠ΅ΡΡΠΈΠ΅ΠΉ, ΠΊΠΎΡΠΎΡΡΠ΅ ΠΏΠΎΠ·Π²ΠΎΠ»ΡΡΡ ΡΠ²Π΅Π»ΠΈΡΠΈΡΡ Π²Π΅ΡΠΎΡΡΠ½ΠΎΡΡΡ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ², Π½Π΅ ΠΏΠΎΠ΄Π΄Π°ΡΡΠΈΡ
ΡΡ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΡ ΠΊΠ»Π°ΡΡΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠΌΠΈ.Π’Π°ΠΊΠΆΠ΅ ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ, Π² ΠΊΠΎΡΠΎΡΡΡ
ΠΏΡΠ΅Π΄Π»Π°Π³Π°Π΅ΡΡΡ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΠΏΠΎΠ»Π΅ΠΉ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠΉ ΠΊΠΎΠ½ΡΠΈΠ³ΡΡΠ°ΡΠΈΠΈ Π² Π·Π°Π΄Π°Π½Π½ΠΎΠΉ Π·ΠΎΠ½Π΅ Ρ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠΌΠ°Π³Π½ΠΈΡΠΎΠΏΡΠΎΠ²ΠΎΠ΄ΠΎΠ², ΠΊΠΎΠ½ΡΠ΅Π½ΡΡΠ°ΡΠΎΡΠΎΠ² ΠΏΠΎΠ»Ρ ΠΈΠ· ΠΏΡΠΎΠ²ΠΎΠ΄ΡΡΠΈΡ
ΠΌΠ°ΡΠ΅ΡΠΈΠ°Π»ΠΎΠ² ΠΈ ΡΠΊΡΠ°Π½ΠΎΠ² ΡΠΏΠ΅ΡΠΈΠ°Π»ΡΠ½ΠΎΠΉ ΡΠΎΡΠΌΡ. ΠΠ·ΡΡΠ°Π»ΠΈΡΡ ΠΏΠΎΠ΄Ρ
ΠΎΠ΄Ρ ΠΊ ΡΠ΅Π°Π»ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠΏΡΠΈΠΌΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΠΈΠ½ΡΠ΅Π·Π° ΡΠΈΡΡΠ΅ΠΌ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Ρ ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ Π² Π·ΠΎΠ½Π΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Ρ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ ΡΡΡΡΠΎΠ³Π°ΡΠ½ΠΎΠΉ ΠΎΠΏΡΠΈΠΌΠΈΠ·Π°ΡΠΈΠΈ Π΄Π»Ρ ΡΠ»ΡΡΠ°Π΅Π² Π΄Π²ΠΈΠΆΡΡΠΈΡ
ΡΡ ΠΎΠ±ΡΠ΅ΠΊΡΠΎΠ² ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ Ρ ΡΡΡΡΠΎΠΌ ΡΡΡΠ΅ΠΊΡΠ° ΡΠΊΠΎΡΠΎΡΡΠΈ. ΠΠ±ΠΎΠ±ΡΡΠ½ ΠΈ ΡΠΈΡΡΠ΅ΠΌΠ°ΡΠΈΠ·ΠΈΡΠΎΠ²Π°Π½ ΠΎΠΏΡΡ, Π° ΡΠ°ΠΊΠΆΠ΅ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ΅ΠΎΡΠ΅ΡΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, ΠΏΠΎΡΠ²ΡΡΡΠ½-Π½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ΅ ΠΏΡΠΎΠ΅ΠΊΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΠΈΡ
ΡΠ΅ΡΠΎΠΊΠΎΠ²ΡΡ
ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ Ρ ΡΠ°Π²Π½ΠΎΠΌΠ΅ΡΠ½ΠΎΠΉ ΡΡΠ²ΡΡΠ²ΠΈΡΠ΅Π»ΡΠ½ΠΎΡΡΡΡ Π² Π·ΠΎΠ½Π΅ ΠΊΠΎΠ½ΡΡΠΎΠ»Ρ, ΠΎΠ±ΡΡΠ»ΠΎΠ²Π»Π΅Π½Π½ΠΎΠΉ ΠΎΠ΄Π½ΠΎΡΠΎΠ΄Π½ΡΠΌ ΡΠ°ΡΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΏΠ»ΠΎΡΠ½ΠΎΡΡΠΈ ΠΈΠ½Π΄ΡΡΠΈΡΠΎΠ²Π°Π½Π½ΡΡ
ΡΠΎΠΊΠΎΠ², ΠΏΡΠΎΡΠ΅ΠΊΠ°ΡΡΠΈΡ
Π² ΠΎΠ±ΡΠ΅ΠΊΡΠ΅. ΠΡΠ΅Π΄Π»ΠΎΠΆΠ΅Π½Π° ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ ΠΏΡΠ΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»Π΅ΠΉ ΠΏΠΎ ΡΡΠ΄Ρ ΠΏΡΠΈΠ·Π½Π°ΠΊΠΎΠ², Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΠΈΡ
ΠΈΡ
ΡΠΈΡΡΠ΅ΠΌΡ Π²ΠΎΠ·Π±ΡΠΆΠ΄Π΅Π½ΠΈΡ
Magnetic and Newtonian noises in Advanced Virgo: evaluation and mitigation strategies
In the present study, I table the first detailed estimation of the magnetic noise contribution to the Advanced Virgo sensitivity to gravitational waves.
I tackle the topic by performing experimental assessments and numerical finite element simulations, all accompanied by careful data analysis.
Results suggest that the magnetic noise impact for Advanced Virgo is not dramatic, but it will eventually be a considerable issue once the detector will approach its final design.
In anticipation of that, I propose a mitigation strategy based on passive magnetic field shielding.
In the second part, I deal with seismic newtonian noise, focusing on two crucial aspects involving the noise cancellation pipeline. These are the choice of the subtraction filter and the optimization of the seismic sensor array placement.
The former issue required the definition of a machine learning algorithm based on deep neural networks, and its fine tuning.
Results give some indication of good performances compared to the standard Wiener filter approach.
The problem of the sensors deployment is instead addressed with the finite element analysis of the actual Virgo infrastructure and underground soil layers surrounding the test masses
Accelerated neuromorphic cybernetics
Accelerated mixed-signal neuromorphic hardware refers to electronic systems that emulate electrophysiological aspects of biological nervous systems in analog voltages and currents in an accelerated manner. While the functional spectrum of these systems already includes many observed neuronal capabilities, such as learning or classification, some areas remain largely unexplored. In particular, this concerns cybernetic scenarios in which nervous systems engage in closed interaction with their bodies and environments. Since the control of behavior and movement in animals is both the purpose and the cause of the development of nervous systems, such processes are, however, of essential importance in nature. Besides the design of neuromorphic circuit- and system components, the main focus of this work is therefore the construction and analysis of accelerated neuromorphic agents that are integrated into cybernetic chains of action. These agents are, on the one hand, an accelerated mechanical robot, on the other hand, an accelerated virtual insect. In both cases, the sensory organs and actuators of their artificial bodies are derived from the neurophysiology of the biological prototypes and are reproduced as faithfully as possible. In addition, each of the two biomimetic organisms is subjected to evolutionary optimization, which illustrates the advantages of accelerated neuromorphic nervous systems through significant time savings
Frustration in Biomolecules
Biomolecules are the prime information processing elements of living matter.
Most of these inanimate systems are polymers that compute their structures and
dynamics using as input seemingly random character strings of their sequence,
following which they coalesce and perform integrated cellular functions. In
large computational systems with a finite interaction-codes, the appearance of
conflicting goals is inevitable. Simple conflicting forces can lead to quite
complex structures and behaviors, leading to the concept of "frustration" in
condensed matter. We present here some basic ideas about frustration in
biomolecules and how the frustration concept leads to a better appreciation of
many aspects of the architecture of biomolecules, and how structure connects to
function. These ideas are simultaneously both seductively simple and perilously
subtle to grasp completely. The energy landscape theory of protein folding
provides a framework for quantifying frustration in large systems and has been
implemented at many levels of description. We first review the notion of
frustration from the areas of abstract logic and its uses in simple condensed
matter systems. We discuss then how the frustration concept applies
specifically to heteropolymers, testing folding landscape theory in computer
simulations of protein models and in experimentally accessible systems.
Studying the aspects of frustration averaged over many proteins provides ways
to infer energy functions useful for reliable structure prediction. We discuss
how frustration affects folding, how a large part of the biological functions
of proteins are related to subtle local frustration effects and how frustration
influences the appearance of metastable states, the nature of binding
processes, catalysis and allosteric transitions. We hope to illustrate how
Frustration is a fundamental concept in relating function to structural
biology.Comment: 97 pages, 30 figure
Intermittent Theta Burst Stimulation: Application to Spinal Cord Injury Rehabilitation and Computational Modeling
Loss of motor function from spinal cord injuries (SCI) results in loss of independence. Rehabilitation efforts are targeted to enhance the ability to perform activities of daily living (ADLs), but outcomes from physical therapy alone are often insufficient. Neuromodulation techniques that induce neuroplasticity may push the limits on recovery. Neuromodulation by intermittent theta burst transcranial magnetic stimulation (iTBS) induces neuroplasticity by increasing corticomotor excitability, though this has most frequently been studied with motor targets and on individuals not in need of rehabilitation. Increased corticomotor excitability is associated with motor learning. The response to iTBS, however, is highly variable and unpredictable, while the mechanisms are not well understood. Studies have proposed brain anatomy and individual subject differences as a source of variability but have not quantified the effects. Existing models have not incorporated known neurotransmitter changes at the synaptic level to pair mechanisms to cell output in a neural circuit. To use iTBS in practical rehabilitative efforts, the technique must either be consistent, have a predictable responsiveness, or present with enough mechanistic understanding to improve its efficacy.
To that effect, this study has two primary objectives for the improvement of rehabilitation techniques. The first is to establish how iTBS affects both a motor target and population that typically undergoes physical rehabilitation often with unsatisfactory outcomes, in this case the biceps brachii in individuals with SCI and relate the empirical effects of iTBS to individual anatomy. This will establish the consistency of the technique and predictability of its effects, relevant to rehabilitative efforts. The secondary objective is to create the foundation of a model that exhibits circuit organization, which would start the development of a motor neuroplasticity functional unit with simulation of the synaptic long-term potentiation (LTP) like effects of iTBS.
Summary of Methods: iTBS was performed targeting the biceps, on multiple cohorts, with changes in motor evoked potential amplitude (MEP) tracked after sham and active intervention. This was compared between nonimpaired individuals and those with SCI. Furthermore, iTBS of both biceps and first dorsal interosseus (FDI) was compared to simulation of TMS on MRI derived head models to establish the impact of individualized neuroanatomy. Finally, a motor canonical neural circuit was programmed to display fundamental physiological spiking behavior of membrane potentials.
Summary of Results: iTBS did facilitate corticomotor excitability in the biceps of nonimpaired individuals and in those with SCI. iTBS had no group-wide effect on the FDI, highlighting the variability in response to the protocol. TMS response (motor thresholds) and iTBS response (change in MEPs) both were related to parameters extracted from MRI-derived head models representing variations in individual neuroanatomy. The neural circuit model represents a canonical networked unit. In the future, this can be further tuned to exhibit biological variability and generate population-based values being run in parallel, while matching the understood mechanisms of neuroplasticity: disinhibition and LTP.
Conclusion: These studies provide missing information of iTBS responsivity by (1) determining group-wide responsiveness in a clinically relevant target; (2) establishing individual level influences that affect responsivity which can be measured prior to iTBS; and (3) beginning design of a tool to test a single neural circuit and its mechanistic responses
Computerized Analysis of Magnetic Resonance Images to Study Cerebral Anatomy in Developing Neonates
The study of cerebral anatomy in developing neonates is of great importance for
the understanding of brain development during the early period of life. This
dissertation therefore focuses on three challenges in the modelling of cerebral
anatomy in neonates during brain development. The methods that have been
developed all use Magnetic Resonance Images (MRI) as source data.
To facilitate study of vascular development in the neonatal period, a set of image
analysis algorithms are developed to automatically extract and model cerebral
vessel trees. The whole process consists of cerebral vessel tracking from
automatically placed seed points, vessel tree generation, and vasculature
registration and matching. These algorithms have been tested on clinical Time-of-
Flight (TOF) MR angiographic datasets.
To facilitate study of the neonatal cortex a complete cerebral cortex segmentation
and reconstruction pipeline has been developed. Segmentation of the neonatal
cortex is not effectively done by existing algorithms designed for the adult brain
because the contrast between grey and white matter is reversed. This causes pixels
containing tissue mixtures to be incorrectly labelled by conventional methods. The
neonatal cortical segmentation method that has been developed is based on a novel
expectation-maximization (EM) method with explicit correction for mislabelled
partial volume voxels. Based on the resulting cortical segmentation, an implicit
surface evolution technique is adopted for the reconstruction of the cortex in
neonates. The performance of the method is investigated by performing a detailed
landmark study.
To facilitate study of cortical development, a cortical surface registration algorithm
for aligning the cortical surface is developed. The method first inflates extracted
cortical surfaces and then performs a non-rigid surface registration using free-form
deformations (FFDs) to remove residual alignment. Validation experiments using
data labelled by an expert observer demonstrate that the method can capture local
changes and follow the growth of specific sulcus
Theoretical Engineering and Satellite Comlink of a PTVD-SHAM System
This paper focuses on super helical memory system's design, 'Engineering,
Architectural and Satellite Communications' as a theoretical approach of an
invention-model to 'store time-data'. The current release entails three
concepts: 1- an in-depth theoretical physics engineering of the chip including
its, 2- architectural concept based on VLSI methods, and 3- the time-data
versus data-time algorithm. The 'Parallel Time Varying & Data Super-helical
Access Memory' (PTVD-SHAM), possesses a waterfall effect in its architecture
dealing with the process of voltage output-switch into diverse logic and
quantum states described as 'Boolean logic & image-logic', respectively.
Quantum dot computational methods are explained by utilizing coiled carbon
nanotubes (CCNTs) and CNT field effect transistors (CNFETs) in the chip's
architecture. Quantum confinement, categorized quantum well substrate, and
B-field flux involvements are discussed in theory. Multi-access of coherent
sequences of 'qubit addressing' in any magnitude, gained as pre-defined, here
e.g., the 'big O notation' asymptotically confined into singularity while
possessing a magnitude of 'infinity' for the orientation of array displacement.
Gaussian curvature of k(k<0) is debated in aim of specifying the
2D electron gas characteristics, data storage system for defining short and
long time cycles for different CCNT diameters where space-time continuum is
folded by chance for the particle. Precise pre/post data timing for, e.g.,
seismic waves before earthquake mantle-reach event occurrence, including time
varying self-clocking devices in diverse geographic locations for radar systems
is illustrated in the Subsections of the paper. The theoretical fabrication
process, electromigration between chip's components is discussed as well.Comment: 50 pages, 10 figures (3 multi-figures), 2 tables. v.1: 1 postulate
entailing hypothetical ideas, design and model on future technological
advances of PTVD-SHAM. The results of the previous paper [arXiv:0707.1151v6],
are extended in order to prove some introductory conjectures in theoretical
engineering advanced to architectural analysi
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