6,225 research outputs found
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Integrative machine learning approach for multi-class SCOP protein fold classification
Classification and prediction of protein structure has been a central research theme in structural bioinformatics. Due to the imbalanced distribution of proteins over multi SCOP classification, most discriminative machine learning suffers the well-known ‘False Positives ’ problem when learning over these types of problems. We have devised eKISS, an ensemble machine learning specifically designed to increase the coverage of positive examples when learning under multiclass imbalanced data sets. We have applied eKISS to classify 25 SCOP folds and show that our learning system improved over classical learning methods
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Multi-class protein fold classification using a new ensemble machine learning approach.
Protein structure classification represents an important process in understanding the associations
between sequence and structure as well as possible functional and evolutionary relationships.
Recent structural genomics initiatives and other high-throughput experiments have populated the
biological databases at a rapid pace. The amount of structural data has made traditional methods
such as manual inspection of the protein structure become impossible. Machine learning has been
widely applied to bioinformatics and has gained a lot of success in this research area. This work
proposes a novel ensemble machine learning method that improves the coverage of the classifiers
under the multi-class imbalanced sample sets by integrating knowledge induced from different base
classifiers, and we illustrate this idea in classifying multi-class SCOP protein fold data. We have
compared our approach with PART and show that our method improves the sensitivity of the
classifier in protein fold classification. Furthermore, we have extended this method to learning over
multiple data types, preserving the independence of their corresponding data sources, and show
that our new approach performs at least as well as the traditional technique over a single joined
data source. These experimental results are encouraging, and can be applied to other bioinformatics
problems similarly characterised by multi-class imbalanced data sets held in multiple data
sources
A systematic review of data quality issues in knowledge discovery tasks
Hay un gran crecimiento en el volumen de datos porque las organizaciones capturan permanentemente la cantidad colectiva de datos para lograr un mejor proceso de toma de decisiones. El desafío mas fundamental es la exploración de los grandes volúmenes de datos y la extracción de conocimiento útil para futuras acciones por medio de tareas para el descubrimiento del conocimiento; sin embargo, muchos datos presentan mala calidad. Presentamos una revisión sistemática de los asuntos de calidad de datos en las áreas del descubrimiento de conocimiento y un estudio de caso aplicado a la enfermedad agrícola conocida como la roya del café.Large volume of data is growing because the organizations are continuously capturing the collective amount of data for better decision-making process. The most fundamental challenge is to explore the large volumes of data and extract useful knowledge for future actions through knowledge discovery tasks, nevertheless many data has poor quality. We presented a systematic review of the data quality issues in knowledge discovery tasks and a case study applied to agricultural disease named coffee rust
Analysis of group evolution prediction in complex networks
In the world, in which acceptance and the identification with social
communities are highly desired, the ability to predict evolution of groups over
time appears to be a vital but very complex research problem. Therefore, we
propose a new, adaptable, generic and mutli-stage method for Group Evolution
Prediction (GEP) in complex networks, that facilitates reasoning about the
future states of the recently discovered groups. The precise GEP modularity
enabled us to carry out extensive and versatile empirical studies on many
real-world complex / social networks to analyze the impact of numerous setups
and parameters like time window type and size, group detection method,
evolution chain length, prediction models, etc. Additionally, many new
predictive features reflecting the group state at a given time have been
identified and tested. Some other research problems like enriching learning
evolution chains with external data have been analyzed as well
Is "Better Data" Better than "Better Data Miners"? (On the Benefits of Tuning SMOTE for Defect Prediction)
We report and fix an important systematic error in prior studies that ranked
classifiers for software analytics. Those studies did not (a) assess
classifiers on multiple criteria and they did not (b) study how variations in
the data affect the results. Hence, this paper applies (a) multi-criteria tests
while (b) fixing the weaker regions of the training data (using SMOTUNED, which
is a self-tuning version of SMOTE). This approach leads to dramatically large
increases in software defect predictions. When applied in a 5*5
cross-validation study for 3,681 JAVA classes (containing over a million lines
of code) from open source systems, SMOTUNED increased AUC and recall by 60% and
20% respectively. These improvements are independent of the classifier used to
predict for quality. Same kind of pattern (improvement) was observed when a
comparative analysis of SMOTE and SMOTUNED was done against the most recent
class imbalance technique. In conclusion, for software analytic tasks like
defect prediction, (1) data pre-processing can be more important than
classifier choice, (2) ranking studies are incomplete without such
pre-processing, and (3) SMOTUNED is a promising candidate for pre-processing.Comment: 10 pages + 2 references. Accepted to International Conference of
Software Engineering (ICSE), 201
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