Bayesian latent time joint mixed-effects model of progression in the Alzheimer's Disease Neuroimaging Initiative.

IntroductionWe characterize long-term disease dynamics from cognitively healthy to dementia using data from the Alzheimer's Disease Neuroimaging Initiative.MethodsWe apply a latent time joint mixed-effects model to 16 cognitive, functional, biomarker, and imaging outcomes in Alzheimer's Disease Neuroimaging Initiative. Markov chain Monte Carlo methods are used for estimation and inference.ResultsWe find good concordance between latent time and diagnosis. Change in amyloid positron emission tomography shows a moderate correlation with change in cerebrospinal fluid tau (ρ = 0.310) and phosphorylated tau (ρ = 0.294) and weaker correlation with amyloid-β 42 (ρ = 0.176). In comparison to amyloid positron emission tomography, change in volumetric magnetic resonance imaging summaries is more strongly correlated with cognitive measures (e.g., ρ = 0.731 for ventricles and Alzheimer's Disease Assessment Scale). The average disease trends are consistent with the amyloid cascade hypothesis.DiscussionThe latent time joint mixed-effects model can (1) uncover long-term disease trends; (2) estimate the sequence of pathological abnormalities; and (3) provide subject-specific prognostic estimates of the time until onset of symptoms

A Cognitive-based scheme for user reliability and expertise assessment in Q&A social networks

Q&A social media has gained a great deal of attention during recent years. People rely on these sites to obtain information due to the number of advantages they offer as compared to conventional sources of knowledge (e.g., asynchronous and convenient access). However, for the same question one may find highly contradictory answers, causing ambiguity with respect to the correct information. This can be attributed to the presence of unreliable and/or non-expert users. In this work, we propose a novel approach for estimating the reliability and expertise of a user based on human cognitive traits. Every user can individually estimate these values based on local pairwise interactions. We examine the convergence performance of our algorithm and we find that it can accurately assess the reliability and the expertise of a user and can successfully react to the latter's behavior change. © 2011 IEEE

Sustainability appraisal: Jack of all trades, master of none?

Sustainable development is a commonly quoted goal for decision making and supports a large number of other discourses. Sustainability appraisal has a stated goal of supporting decision making for sustainable development. We suggest that the inherent flexibility of sustainability appraisal facilitates outcomes that often do not adhere to the three goals enshrined in most definitions of sustainable development: economic growth, environmental protection and enhancement, and the wellbeing of the human population. Current practice is for sustainable development to be disenfranchised through the interpretation of sustainability, whereby the best alternative is good enough even when unsustainable. Practitioners must carefully and transparently review the frameworks applied during sustainability appraisal to ensure that outcomes will meet the three goals, rather than focusing on a discourse that emphasises one or more goals at the expense of the other(s)

The EPSRC's policy of responsible innovation from a trading zones perspective

Responsible innovation (RI) is gathering momentum as an academic and policy debate linking science and society. Advocates of RI in research policy argue that scientific research should be opened up at an early stage so that many actors and issues can steer innovation trajectories. If this is done, they suggest, new technologies will be more responsible in different ways, better aligned with what society wants, and mistakes of the past will be avoided. This paper analyses the dynamics of RI in policy and practice and makes recommendations for future development. More specifically, we draw on the theory of ‘trading zones’ developed by Peter Galison and use it to analyse two related processes: (i) the development and inclusion of RI in research policy at the UK’s Engineering and Physical Sciences Research Council (EPSRC); (ii) the implementation of RI in relation to the Stratospheric Particle Injection for Climate Engineering (SPICE) project. Our analysis reveals an RI trading zone comprised of three quasi-autonomous traditions of the research domain – applied science, social science and research policy. It also shows how language and expertise are linking and coordinating these traditions in ways shaped by local conditions and the wider context of research. Building on such insights, we argue that a sensible goal for RI policy and practice at this stage is better local coordination of those involved and we suggest ways how this might be achieved

The Sporting Image: A Personal Journey Utilising History to Develop Academic Inquiry and Creativity

In 1997, an optional third year undergraduate module, The Sporting Image, was developed for sports studies students in which they scrutinized the portrayal of sport in popular and high culture; including literature, film, TV, art and music. Fifteen years later, this module, now compulsory for Sports Journalism students, continues to examine the portrayal of sport and ways in which it has become an integral part of popular culture and resonates with values and standards specific in time and place. This paper describes the evolution of the module and its successes and failures in obliging both the lecturers and students to move outside of their comfort zones and engage with creative writing, poetry, music and the visual arts

Evolutionary Debunking and Moral Relativism

Our aim here is to explore the prospects of a relativist response to moral debunking arguments. We begin by clarifying the relativist thesis under consideration, and we explain why relativists seem well-positioned to resist the arguments in a way that avoids the drawbacks of existing responses. We then show that appearances are deceiving. At bottom, the relativist response is no less question-begging than standard realist responses, and – when we turn our attention to the strongest formulation of the debunking argument – the virtues of relativism turn out to be vices

Construction and Constraint: Discussion of Living Originalism

Jack Balkin\u27s Living Originalism raises many important questions about contemporary constitutional theory. Can and should liberals and progressives embrace originalism? Can the New Deal expansion of national legislative power be given originalist foundations? Is there a plausible originalist case for a right to reproductive autonomy and hence for the Court\u27s decision in Roe v. Wade? Is the fact of theoretical disagreement among originalists evidence for the thesis that the originalist project is in disarray

The development of freshwater science in Britain, and British contributions abroad, 1900-2000

This article outlines the development of freshwater science between 1900 and 2000 and in particular traces British contributions, both to a deepened knowledge of specifics and to their interrelation as environmental and ecological science. The author provides a selected bibliography of important publications relevant to the topic of the article

Purposive Teaching Styles for Transdisciplinary AEC Education: A Diagnostic Learning Styles Questionnaire

With the progressive globalisation trend within the Architecture, Engineering, and Construction (AEC) industry, transdisciplinary education and training is widely acknowledged as being one of the key factors for leveraging AEC organisational success. Conventional education and training delivery approaches within AEC therefore need a paradigm shift in order to be able to address the emerging challenges of global practices. This study focuses on the use of Personalised Learning Environments (PLEs) to specifically address learners’ needs and preferences (learning styles) within managed Virtual Learning Environments (VLEs). This research posits that learners can learn better (and be more readily engaged in managed learning environments) with a bespoke PLE, in which the deployment of teaching and learning material is augmented towards their individual needs. In this respect, there is an exigent need for the Higher Educational Institutions (HEIs) to envelop these new approaches into their organisational learning strategy. However, part of this process requires decision-makers to fully understand the core nuances and interdependencies of functions and processes within the organisation, along with Critical Success Factors (CSFs) and barriers. This paper presents findings from the development of a holistic conceptual Diagnostic Learning Styles Questionnaire (DLSQ) Framework, comprised of six interrelated dependencies (i.e. Business Strategy, Pedagogy, Process, Resources, Systems Development, and Evaluation). These dependencies influence pedagogical effectiveness. These finding contribute additional understanding to the intrinsic nature of pedagogy in leveraging transdisciplinary AEC training within organisations (to improve learner effectiveness). This framework can help organisations augment and align their strategic priorities to learner-specific traits