Computing in the RAIN: a reliable array of independent nodes

The RAIN project is a research collaboration between Caltech and NASA-JPL on distributed computing and data-storage systems for future spaceborne missions. The goal of the project is to identify and develop key building blocks for reliable distributed systems built with inexpensive off-the-shelf components. The RAIN platform consists of a heterogeneous cluster of computing and/or storage nodes connected via multiple interfaces to networks configured in fault-tolerant topologies. The RAIN software components run in conjunction with operating system services and standard network protocols. Through software-implemented fault tolerance, the system tolerates multiple node, link, and switch failures, with no single point of failure. The RAIN-technology has been transferred to Rainfinity, a start-up company focusing on creating clustered solutions for improving the performance and availability of Internet data centers. In this paper, we describe the following contributions: 1) fault-tolerant interconnect topologies and communication protocols providing consistent error reporting of link failures, 2) fault management techniques based on group membership, and 3) data storage schemes based on computationally efficient error-control codes. We present several proof-of-concept applications: a highly-available video server, a highly-available Web server, and a distributed checkpointing system. Also, we describe a commercial product, Rainwall, built with the RAIN technology

Typing tumors using pathways selected by somatic evolution.

Many recent efforts to analyze cancer genomes involve aggregation of mutations within reference maps of molecular pathways and protein networks. Here, we find these pathway studies are impeded by molecular interactions that are functionally irrelevant to cancer or the patient's tumor type, as these interactions diminish the contrast of driver pathways relative to individual frequently mutated genes. This problem can be addressed by creating stringent tumor-specific networks of biophysical protein interactions, identified by signatures of epistatic selection during tumor evolution. Using such an evolutionarily selected pathway (ESP) map, we analyze the major cancer genome atlases to derive a hierarchical classification of tumor subtypes linked to characteristic mutated pathways. These pathways are clinically prognostic and predictive, including the TP53-AXIN-ARHGEF17 combination in liver and CYLC2-STK11-STK11IP in lung cancer, which we validate in independent cohorts. This ESP framework substantially improves the definition of cancer pathways and subtypes from tumor genome data

The building blocks of a resource-based theory of business start-ups

Firm dynamics are commonly explained through learning processes by evolutionary economics and resource-based theories of the firm. The literature, however, also highlights the methodological difficulty to unpack learning. With the support of cognitive-behavioural theories of learning and the use of a multi-method approach, this study investigates the evolution of business start- ups and interactions between markets, institutions and learning strategies. In retrospective interviews, entrepreneurs-founders of 43 Brazilian start-ups reconstructed the storyline of the first three to five years of their firms, focussing on critical learning episodes. Analyses of the narratives resulted in 207 critical learning episodes, based on the analytical framework, empirical content, expert evaluation and the literature. These episodes were clustered in five categories. Quantitative descriptive analysis showed the cross-cutting dynamics of these episodes. Then, relationships between episodes were investigated through grounded theory principles. Results showed that the key linking factor between episodes is the resource-base of each episode, which generated five typical pathways. The final step identified the properties of these pathways. It is argued that the iteration between qualitative and quantitative methods was crucial to unpack the relationships described. This study provides a viable methodology and a comprehensive framework to investigate the evolution of business start-ups, contributing to the literature on organizational learning, entrepreneurship, and theory of the firm

A real-time early warning seismic event detection algorithm using smart geo-spatial bi-axial inclinometer nodes for Industry 4.0 applications

Earthquakes are one of the major natural calamities as well as a prime subject of interest for seismologists, state agencies, and ground motion instrumentation scientists. The real-time data analysis of multi-sensor instrumentation is a valuable knowledge repository for real-time early warning and trustworthy seismic events detection. In this work, an early warning in the first 1 micro-second and seismic wave detection in the first 1.7 milliseconds after event initialization is proposed using a seismic wave event detection algorithm (SWEDA). The SWEDA with nine low-computation-cost operations is being proposed for smart geospatial bi-axial inclinometer nodes (SGBINs) also utilized in structural health monitoring systems. SWEDA detects four types of seismic waves, i.e., primary (P) or compression, secondary (S) or shear, Love (L), and Rayleigh (R) waves using time and frequency domain parameters mapped on a 2D mapping interpretation scheme. The SWEDA proved automated heterogeneous surface adaptability, multi-clustered sensing, ubiquitous monitoring with dynamic Savitzky-Golay filtering and detection using nine optimized sequential and structured event characterization techniques. Furthermore, situation-conscious (context-aware) and automated computation of short-time average over long-time average (STA/LTA) triggering parameters by peak-detection and run-time scaling arrays with manual computation support were achieved. - 2019 by the authors.Funding: This publication was made possible by the NPRP grant # 8-1781-2-725 from the Qatar National Research Fund (a member of Qatar Foundation). The statements made herein are solely the responsibility of the authors.Scopu

A Gamefied Synthetic Environment for Evaluation of Counter-Disinformation Solutions

This paper presents a simulation-based approach to countering online dis/misinformation. This disruptive technology experiment incorporated a synthetic environment component, based on adapted SIR epidemiological model to evaluate and visualize the effectiveness of suggested solutions to the issue. The participants in the simulation were given a realistic scenario depicting a dis/misinformation threat and were asked to select a number of solutions, described in IoS (Ideas-of-Systems) cards. During the event, the qualitative and quantitative characteristics of the IoS cards, were tested in a synthetic environment (SEN), built after a Susceptible-Infected-Resistant (SIR) model. The participants, divided into teams, presented and justified their dis/misinformation strategy which included three IoS card selections. A jury of subject matter experts, announced the winning team, based on the merits of the proposed strategies and the compatibility of the different cards, grouped together

Resilience-oriented control and communication framework for cyber-physical microgrids

Climate change drives the energy supply transition from traditional fossil fuel-based power generation to renewable energy resources. This transition has been widely recognised as one of the most significant developing pathways promoting the decarbonisation process toward a zero-carbon and sustainable society. Rapidly developing renewables gradually dominate energy systems and promote the current energy supply system towards decentralisation and digitisation. The manifestation of decentralisation is at massive dispatchable energy resources, while the digitisation features strong cohesion and coherence between electrical power technologies and information and communication technologies (ICT). Massive dispatchable physical devices and cyber components are interdependent and coupled tightly as a cyber-physical energy supply system, while this cyber-physical energy supply system currently faces an increase of extreme weather (e.g., earthquake, flooding) and cyber-contingencies (e.g., cyberattacks) in the frequency, intensity, and duration. Hence, one major challenge is to find an appropriate cyber-physical solution to accommodate increasing renewables while enhancing power supply resilience. The main focus of this thesis is to blend centralised and decentralised frameworks to propose a collaboratively centralised-and-decentralised resilient control framework for energy systems i.e., networked microgrids (MGs) that can operate optimally in the normal condition while can mitigate simultaneous cyber-physical contingencies in the extreme condition. To achieve this, we investigate the concept of "cyber-physical resilience" including four phases, namely prevention/upgrade, resistance, adaption/mitigation, and recovery. Throughout these stages, we tackle different cyber-physical challenges under the concept of microgrid ranging from a centralised-to-decentralised transitional control framework coping with cyber-physical out of service, a cyber-resilient distributed control methodology for networked MGs, a UAV assisted post-contingency cyber-physical service restoration, to a fast-convergent distributed dynamic state estimation algorithm for a class of interconnected systems.Open Acces