657 research outputs found
Adverse Drug Event Detection, Causality Inference, Patient Communication and Translational Research
Adverse drug events (ADEs) are injuries resulting from a medical intervention related to a drug. ADEs are responsible for nearly 20% of all the adverse events that occur in hospitalized patients. ADEs have been shown to increase the cost of health care and the length of stays in hospital. Therefore, detecting and preventing ADEs for pharmacovigilance is an important task that can improve the quality of health care and reduce the cost in a hospital setting. In this dissertation, we focus on the development of ADEtector, a system that identifies ADEs and medication information from electronic medical records and the FDA Adverse Event Reporting System reports. The ADEtector system employs novel natural language processing approaches for ADE detection and provides a user interface to display ADE information. The ADEtector employs machine learning techniques to automatically processes the narrative text and identify the adverse event (AE) and medication entities that appear in that narrative text. The system will analyze the entities recognized to infer the causal relation that exists between AEs and medications by automating the elements of Naranjo score using knowledge and rule based approaches. The Naranjo Adverse Drug Reaction Probability Scale is a validated tool for finding the causality of a drug induced adverse event or ADE. The scale calculates the likelihood of an adverse event related to drugs based on a list of weighted questions. The ADEtector also presents the user with evidence for ADEs by extracting figures that contain ADE related information from biomedical literature. A brief summary is generated for each of the figures that are extracted to help users better comprehend the figure. This will further enhance the user experience in understanding the ADE information better. The ADEtector also helps patients better understand the narrative text by recognizing complex medical jargon and abbreviations that appear in the text and providing definitions and explanations for them from external knowledge resources. This system could help clinicians and researchers in discovering novel ADEs and drug relations and also hypothesize new research questions within the ADE domain
A general framework for the annotation of causality based on FrameNet
International audienceWe present here a general set of semantic frames to annotate causal expressions, with a rich lexicon in French and an annotated corpus of about 4000 instances of causal lexical items with their corresponding semantic frames. The aim of our project is to have both the largest possible coverage of causal phenomena in French, across all parts of speech, and have it linked to a general semantic framework such as FN, to benefit in particular from the relations between other semantic frames, e.g., temporal ones or intentional ones, and the underlying upper lexical ontology that enables some forms of reasoning. This is part of the larger ASFALDA French FrameNet project, which focuses on a few different notional domains which are interesting in their own right (Djemaa et al., 2016), including cognitive positions and communication frames. In the process of building the French lexicon and preparing the annotation of the corpus, we had to remodel some of the frames proposed in FN based on English data, with hopefully more precise frame definitions to facilitate human annotation. This includes semantic clarifications of frames and frame elements, redundancy elimination, and added coverage. The result is arguably a significant improvement of the treatment of causality in FN itself
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