A novel approach to modelling and simulating the contact behaviour between a human hand model and a deformable object

A deeper understanding of biomechanical behaviour of human hands becomes fundamental for any human hand-operated Q2 activities. The integration of biomechanical knowledge of human hands into product design process starts to play an increasingly important role in developing an ergonomic product-to-user interface for products and systems requiring high level of comfortable and responsive interactions. Generation of such precise and dynamic models can provide scientific evaluation tools to support product and system development through simulation. This type of support is urgently required in many applications such as hand skill training for surgical operations, ergonomic study of a product or system developed and so forth. The aim of this work is to study the contact behaviour between the operators’ hand and a hand-held tool or other similar contacts, by developing a novel and precise nonlinear 3D finite element model of the hand and by investigating the contact behaviour through simulation. The contact behaviour is externalised by solving the problem using the bi-potential method. The human body’s biomechanical characteristics, such as hand deformity and structural behaviour, have been fully modelled by implementing anisotropic hyperelastic laws. A case study is given to illustrate the effectiveness of the approac

Nonsmooth Nonconvex Variational Reconstruction for Electrical Impedance Tomography

Electrical Impedance Tomography is an imaging technique that aims to reconstruct the inner conductivity distribution of a medium starting from a set of measured voltages registered by a series of electrodes that are positioned on the surface of the medium. Such technique was used for the first time in geological studies in 1930 and then applied to industrial procedures. The first clinical use of EIT dates back to 1987. In 2018 EIT was validated in tissue engineering as a noninvasive and label-free imaging and monitoring tool for cell distribution (cell growth, differentiation and tissue formation) in 3D scaffolds. EIT problem can be split into a Forward and an Inverse problem. The aim of Forward EIT is to define the set of measured voltages starting from a known conductivity distribution. If the forward problem is characterized by a nonlinear mapping, called Forward Operator, from the conductivity distribution to the measured voltages, inverse EIT consists of inverting the Forward Operator. This leads to an ill-posed problem which requires regularization, either in the model or in the numerical method that is applied to define the solution. The inverse problem is modelled as a Nonlinear Least Squares problem, where one seeks to minimize the mismatch beetween the measured voltages and the ones generated by the reconstructed conductivity. Reconstruction techniques require the introduction of a regularization term which forces the reconstructed data to stick to certain prior information. In this dissertation, some state-of-the-art regularization methods are analyzed and compared via EIDORS, a specific software for EIT problems. The aim is to reconstruct the variation in conductivity within a 2D section of a 3D scaffold. Furthermore a variational formulation on a 2D mesh for a space-variant regularization is proposed, based on a combination of high order and nonconvex operators, which respectively seek to recover piecewise inhomogeneous and piecewise linear regions

Mathematical methods for magnetic resonance based electric properties tomography

Magnetic resonance-based electric properties tomography (MREPT) is a recent quantitative imaging technique that could provide useful additional information to the results of magnetic resonance imaging (MRI) examinations. Precisely, MREPT is a collective name that gathers all the techniques that elaborate the radiofrequency (RF) magnetic field B1 generated and measured by a MRI scanner in order to map the electric properties inside a human body. The range of uses of MREPT in clinical oncology, patient-specific treatment planning and MRI safety motivates the increasing scientific interest in its development. The main advantage of MREPT with respect to other techniques for electric properties imaging is the knowledge of the input field inside the examined body, which guarantees the possibility of achieving high-resolution. On the other hand, MREPT techniques rely on just the incomplete information that MRI scanners can measure of the RF magnetic field, typically limited to the transmit sensitivity B1+. In this thesis, the state of art is described in detail by analysing the whole bibliography of MREPT, started few years ago but already rich of contents. With reference to the advantages and drawbacks of each technique proposed for MREPT, the particular implementation based on the contrast source inversion method is selected as the most promising approach for MRI safety applications and is denoted by the symbol csiEPT. Motivated by this observation, a substantial part of the thesis is devoted to a thoroughly study of csiEPT. Precisely, a generalised framework based on a functional point of view is proposed for its implementation. In this way, it is possible to adapt csiEPT to various physical situations. In particular, an original formulation, specifically developed to take into account the effects of the conductive shield always employed in RF coils, shows how an accurate modelling of the measurement system leads to more precise estimations of the electric properties. In addition, a preliminary study for the uncertainty assessment of csiEPT, an imperative requirement in order to make the method reliable for in vivo applications, is performed. The uncertainty propagation through csiEPT is studied using the Monte Carlo method as prescribed by the Supplement 1 to GUM (Guide to the expression of Uncertainty in Measurement). The robustness of the method when measurements are performed by multi-channel TEM coils for parallel transmission confirms the eligibility of csiEPT for MRI safety applications