Si, CdTe and CdZnTe radiation detectors for imaging applications

The structure and operation of CdTe, CdZnTe and Si pixel detectors based on crystalline semiconductors, bump bonding and CMOS technology and developed mainly at Oy Simage Ltd. And Oy Ajat Ltd., Finland for X- and gamma ray imaging are presented. This detector technology evolved from the development of Si strip detectors at the Finnish Research Institute for High Energy Physics (SEFT) which later merged with other physics research units to form the Helsinki Institute of Physics (HIP). General issues of X-ray imaging such as the benefits of the method of direct conversion of X-rays to signal charge in comparison to the indirect method and the pros and cons of photon counting vs. charge integration are discussed. A novel design of Si and CdTe pixel detectors and the analysis of their imaging performance in terms of SNR, MTF, DQE and dynamic range are presented in detail. The analysis shows that directly converting crystalline semiconductor pixel detectors operated in the charge integration mode can be used in X-ray imaging very close to the theoretical performance limits in terms of efficiency and resolution. Examples of the application of the developed imaging technology to dental intra oral and panoramic and to real time X-ray imaging are given. A CdTe photon counting gamma imager is introduced. A physical model to calculate the photo peak efficiency of photon counting CdTe pixel detectors is developed and described in detail. Simulation results indicates that the charge sharing phenomenon due to diffusion of signal charge carriers limits the pixel size of photon counting detectors to about 250 μm. Radiation hardness issues related to gamma and X-ray imaging detectors are discussed.Työssä esitellään Suomessa kehitettyjä uudentyyppisiä digitaalisia röntgen- ja gammakuvausantureita, jotka perustuvat pii- ja CdTe-puolijohdeteknologiaan. Uuden tekniikan anturit osoitetaan toimivan hyvin lähellä teoreettista optimia. Erinomainen röntgenkuvan laatu saavutetaan pienellä säteilyannoksella. Antureiden rakenne ja toiminta selostetaan seikkaperäisesti ja niiden soveltamisesta hammaskuvaukseen ja reaaliaikaiseen videoröntgenkuvantamiseen annetaan esimerkkejä. Työssä esitellään myös fotonilaskentaan perustuvan CdTe gammakuvausanturin toiminta simuloinnein ja mittauksin sekä käsitellään antureiden säteilynkestoon liittyviä kysymyksiä

Imaging of the Breast

Early detection of breast cancer combined with targeted therapy offers the best outcome for breast cancer patients. This volume deal with a wide range of new technical innovations for improving breast cancer detection, diagnosis and therapy. There is a special focus on improvements in mammographic image quality, image analysis, magnetic resonance imaging of the breast and molecular imaging. A chapter on targeted therapy explores the option of less radical postoperative therapy for women with early, screen-detected breast cancers

A versatile imaging system for in vivo small animal research

In vivo small animal imaging has become an essential technique for molecular biology studies. However, requirements of spatial resolution, sensitivity and image quality are quite challenging for the development of small-animal imaging systems. The capabilities of the system are also significant for carrying out small animal imaging in a wide range of biological studies. The goal of this dissertation is to develop a high-performance imaging system that can readily meet a wide range of requirements for a variety of small animal imaging applications. Several achievements have been made in order to fulfill this goal.;To supplement our system for parallel-hole single photon emission computed tomography (SPECT) based upon a 110 mm diameter circular detector, we have developed novel compact gamma cameras suitable for imaging an entire mouse. These gamma cameras facilitate multi-head (\u3e2) parallel-hole SPECT with the mouse in close proximity to the detector face in order to preserve spatial resolution. Each compact gamma cameras incorporates pixellated Nal(Tl) scintillators and a pair of Hamamatsu H8500 position sensitive photomultiplier tubes (PSPMTs). Two types of copper-beryllium parallel-hole collimators have been designed. These provide high-sensitivity imaging of I-125 or excellent spatial resolution over a range of object-detector distances. Both phantom and animal studies have demonstrated that these gamma cameras perform well for planar scintigraphy and parallel-hole SPECT of mice.;To further address the resolution limitations in parallel-hole SPECT and the sensitivity and limited field of view of single-pinhole SPECT, we have developed novel multipinhole helical SPECT based upon a 110 mm diameter circular detector equipped with a pixellated Nal(Tl) scintillator array. A brass collimator has been designed and produced containing five 1 mm diameter pinholes. Results obtained in SPECT studies of various phantoms show an enlarged field of view, very good resolution and improved sensitivity using this new imaging technique.;These studies in small-animal imaging have been applied to in vivo biological studies related to human health issues including studies of the thyroid and breast cancer. A re-evaluation study of potassium iodide blocking efficiency in radioiodine uptake in mice suggests that the FDA-recommended human dose of stable potassium iodide may not be sufficient to effectively protect the thyroid from radioiodine contamination. Another recent study has demonstrated that multipinhole helical SPECT can resolve the fine structure of the mouse thyroid using a relatively low dose (200 muCi). Another preclinical study has focused on breast tumor imaging using a compact gamma camera and an endogenous reporter gene. In that ongoing study, mammary tumors are imaged at different stages. Preliminary results indicate different functional patterns in the uptake of radiotracers and their potential relationship with other tumor parameters such as tumor size.;In summary, we have developed a versatile imaging system suitable for in vivo small animal research as evidenced by a variety of applications. The modular construction of this system will allow expansion and further development as new needs and new opportunities arise

Active Pixel Sensor Architectures for High Resolution Large Area Digital Imaging

This work extends the technology of amorphous silicon (a-Si) thin film transistors (TFTs) from traditional switching applications to on-pixel signal amplification for large area digital imaging and in particular, is aimed towards enabling emerging low noise, high resolution and high frame rate medical diagnostic imaging modalities such as digital tomosynthesis. A two transistor (2T) pixel amplifier circuit based on a novel charge-gate thin film transistor (TFT) device architecture is introduced to shrink the TFT based pixel readout circuit size and complexity and thus, improve the imaging array resolution and reliability of the TFT fabrication process. The high resolution pixel amplifier results in improved electrical performance such as on-pixel amplification gain, input referred noise and faster readouts. In this research, a charge-gated TFT that operates as both a switched amplifier and driver is used to replace two transistors (the addressing switch and the amplifier transistor) of previously reported three transistor (3T) APS pixel circuits.. In addition to enabling smaller pixels, the proposed 2T pixel amplifier results in better signal-to-noise (SNR) by removing the large flicker noise source associated with the switched TFT and increased pixel transconductance gain since the large ON-state resistance of the switched TFT is removed from the source of the amplifier TFT. Alternate configurations of 2T APS architectures based on source or drain switched TFTs are also investigated, compared, and contrasted to the gate switched architecture using charge-gated TFT. A new driving scheme based on multiple row resetting is introduced which combined with the on-pixel gain of the APS, offers considerable improvements in imaging frame rates beyond those feasible for PPS based pixels. The novel developed 2T APS architectures is implemented in single pixel test structures and in 88 pixel test arrays with a pixel pitch of 100 µm. The devices were fabricated using an in-house developed top-gate TFT fabrication process. Measured characteristics of the test devices confirm the performance expectations of the 2T architecture design. Based on parameters extracted from fabricated TFTs, the input referred noise is calculated, and the instability in pixel transconductance gain over prolonged operation tine is projected for different imaging frame rates. 2T APS test arrays were packaged and integrated with an amorphous selenium (a-Se) direct x-ray detector, and the x-ray response of the a-Se detector integrated with the novel readout circuit was evaluated. The special features of the APS such as non-destructive readout and voltage programmable on-pixel gain control are verified. The research presented in this thesis extends amorphous silicon pixel amplifier technology into the area of high density pixel arrays such as large area medical X-ray imagers for digital mammography tomosynthesis. It underscores novel device and circuit design as an effective method of overcoming the inherent shortcomings of the a-Si material . Although the developed device and circuit ideas were implemented and tested using a-Si TFTs, the scope of the device and circuit designs is not limited to amorphous silicon technology and has the potential to be applied to more mainstream technologies, for example, in CMOS active pixel sensor (APS) based digital cameras

High-resolution fluorescence endomicroscopy for rapid evaluation of breast cancer margins

Breast cancer is a major public health problem world-wide and the second leading cause of cancer-related female deaths. Breast conserving surgery (BCS), in the form of wide local excision (WLE), allows complete tumour resection while maintaining acceptable cosmesis. It is the recommended treatment for a large number of patients with early stage disease or, in more advanced cases, following neoadjuvant chemotherapy. About 30% of patients undergoing BCS require one or more re-operative interventions, mainly due to the presence of positive margins. The standard of care for surgical margin assessment is post-operative examination of histopathological tissue sections. However, this process is invasive, introduces sampling errors and does not provide real-time assessment of the tumour status of radial margins. The objective of this thesis is to improve intra-operative assessment of margin status by performing optical biopsy in breast tissue. This thesis presents several technical and clinical developments related to confocal fluorescence endomicroscopy systems for real-time characterisation of different breast morphologies. The imaging systems discussed employ flexible fibre-bundle based imaging probes coupled to high-speed line-scan confocal microscope set-up. A preliminary study on 43 unfixed breast specimens describes the development and testing of line-scan confocal laser endomicroscope (LS-CLE) to image and classify different breast pathologies. LS-CLE is also demonstrated to assess the intra-operative tumour status of whole WLE specimens and surgical excisions with high diagnostic accuracy. A third study demonstrates the development and testing of a bespoke LS-CLE system with methylene blue (MB), an US Food and Drug Administration (FDA) approved fluorescent agent, and integration with robotic scanner to enable large-area in vivo imaging of breast cancer. The work also addresses three technical issues which limit existing fibre-bundle based fluorescence endomicroscopy systems: i) Restriction to use single fluorescence agent due to low-speed, single excitation and single fluorescence spectral band imaging systems; ii) Limited Field of view (FOV) of fibre-bundle endomicroscopes due to small size of the fibre tip and iii) Limited spatial resolution of fibre-bundle endomicroscopes due to the spacing between the individual fibres leading to fibre-pixelation effects. Details of design and development of a high-speed dual-wavelength LS-CLE system suitable for high-resolution multiplexed imaging are presented. Dual-wavelength imaging is achieved by sequentially switching between 488 nm and 660 nm laser sources for alternate frames, avoiding spectral bleed-through, and providing an effective frame rate of 60 Hz. A combination of hand-held or robotic scanning with real-time video mosaicking, is demonstrated to enable large-area imaging while still maintaining microscopic resolution. Finally, a miniaturised piezoelectric transducer-based fibre-shifting endomicroscope is developed to enhance the resolution over conventional fibre-bundle based imaging systems. The fibre-shifting endomicroscope provides a two-fold improvement in resolution and coupled to a high-speed LS-CLE scanning system, provides real-time imaging of biological samples at 30 fps. These investigations furthered the utility and applications of the fibre-bundle based fluorescence systems for rapid imaging and diagnosis of cancer margins.Open Acces

Liquid crystal hyperspectral imager

Hyperspectral imaging is the collection, processing and analysis of spectral data in numerous contiguous wavelength bands while also providing spatial context. Some of the commonly used instruments for hyperspectral imaging are pushbroom scanning imaging systems, grating based imaging spectrometers and more recently electronically tunable filters. Electronically tunable filters offer the advantages of compactness and absence of mechanically movable parts. Electronically tunable filters have the ability to rapidly switch between wavelengths and provide spatial and spectral information over a large wavelength range. They involve the use of materials whose response to light can be altered in the presence of an external stimulus. While these filters offer some unique advantages, they also present some equally unique challenges. This research work involves the design and development of a multichannel imaging system using electronically tunable Liquid Crystal Fabry-Perot etalons. This instrument is called the Liquid Crystal Hyperspectral Imager (LiCHI). LiCHI images four spectral regions simultaneously and presents a trade-off between spatial and spectral domains. This simultaneity of measurements in multiple wavelengths can be exploited for dynamic and ephemeral events. LiCHI was initially designed for multispectral imaging of space plasmas but its versatility was demonstrated by testing in the field for multiple applications including landscape analysis and anomaly detection. The results obtained after testing of this instrument and analysis of the images are promising and demonstrate LiCHI as a good candidate for hyperspectral imaging. The challenges posed by LiCHI for each of these applications have also been explored

Devices and techniques for the characterization of inverse Compton sources

Innovative intense monochromatic x/ -ray sources are of great interest in the scientific community. A large number of applications in basic and applied physics research, as well as in different science fields, require an intense, monochromatic or quasi-monochromatic, tunable radiation source. Synchrotron radiation is optimal for low energy applications (< 100 keV) but the size and cost of synchrotron facilities prevent a large-scale spread of this kind of source, that is fundamental for applications such as routine clinical diagnostic. Moreover, synchrotron light is not suitable in the case of high energy applications (> 1 MeV), needed primarily for nuclear physics experiments, due to limitations on the maximum energy obtainable for monochromatic beams with synchrotron light. Alternative sources that can overcome such limitations are those based on inverse Compton interaction, which permit to obtain compact and cost-effective sources for low energy applications and can provide monochromatic collimated beam in the high energy range. Inverse Compton is the process in which a photon interacts with a relativistic electron, in this case the electron can transfer a fraction of its energy in the collision, resulting in a backscattered photon with an increased energy. This process can be used to produce hard x/ -rays by the backscattering of low-energy laser photons by a relativistic electron beam. A radiation source based on this interaction is usually called an inverse Compton source, alternatively, it can be called Thomson source when the energies involved allow a classical description of the process, as in the case of Thomson scattering. The work described in this dissertation concerns the devices and techniques developed to perform a characterization of inverse Compton sources. In particular, the work is focused on two major projects: BEATS2 experiment and ELI-NP-GBS proposal of E-Gammas collaboration. BEATS2 is an experiment funded by Istituto Nazionale di Fisica Nucleare (INFN) aimed to study medical applications, specially to mammographic imaging, of the SL-Thomson source of SPARC-LAB at the INFN-LNF that will be commissioned in the first half of 2013. E-Gammas is an international collaboration composed by several Universities and Institutions including: INFN and Universit`a di Roma La Sapienza, in Italy, Universitè de Paris Sud and IN2P3/CNRS, in France, and ASTeC of STFC, in UK. The collaboration is aimed to the preparation of a Technical Design Report for the ELI-NP Gamma Beam System (ELI-NP-GBS) to be commissioned by the end of 2016. This Gamma Beam System will be a high energy inverse Compton source, included in the Extreme Light Infrastructure - Nuclear physics (ELI-NP), an European project dedicated to the development of laser beams and the generation of high intensity gamma beams for frontier research in nuclear physics