22,983 research outputs found
An ultra-fast digital diffuse optical spectroscopic imaging system for neoadjuvant chemotherapy monitoring
Up to 20% of breast cancer patients who undergo presurgical (neoadjuvant) chemotherapy have no response to treatment. Standard-of-care imaging modalities, including MRI, CT, mammography, and ultrasound, measure anatomical features and tumor size that reveal response only after months of treatment. Recently, non-invasive, near-infrared optical markers have shown promise in indicating the efficacy of treatment at the outset of the chemotherapy treatment. For example, frequency domain Diffuse Optical Spectroscopic Imaging (DOSI) can be used to characterize the optical scattering and absorption properties of thick tissue, including breast tumors. These parameters can then be used to calculate tissue concentrations of chromophores, including oxyhemoglobin, deoxyhemoglobin, water, and lipids. Tumors differ in hemoglobin concentration, as compared with healthy background tissue, and changes in hemoglobin concentration during neoadjuvant chemotherapy have been shown to correlate with efficacy of treatment. Using DOSI early in treatment to measure chromophore concentrations may be a powerful tool for guiding neoadjuvant chemotherapy treatment.
Previous frequency-domain DOSI systems have been limited by large device footprints, complex electronics, high costs, and slow acquisition speeds, all of which complicate access to patients in the clinical setting. In this work a new digital DOSI (dDOSI) system has been developed, which is relatively inexpensive and compact, allowing for use at the bedside, while providing unprecedented measurement speeds. The system builds on, and significantly advances, previous dDOSI setups developed by our group and, for the first time, utilizes hardware-integrated custom board-level direct digital synthesizers (DDS) and analog to digital converters (ADC) to generate and directly measure signals utilizing undersampling techniques. The dDOSI system takes high-speed optical measurements by utilizing wavelength multiplexing while sweeping through hundreds of modulation frequencies in tens of milliseconds. The new dDOSI system is fast, inexpensive, and compact without compromising accuracy and precision
Developing Model-Based Design Evaluation for Pipelined A/D Converters
This paper deals with a prospective approach of modeling, design evaluation and error determination applied to pipelined A/D converter architecture. In contrast with conventional ADC modeling algorithms targeted to extract the maximum ADC non-linearity error, the innovative approach presented allows to decompose magnitudes of individual error sources from a measured or simulated response of an ADC device. Design Evaluation methodology was successfully applied to Nyquist rate cyclic converters in our works [13]. Now, we extend its principles to pipelined architecture. This qualitative decomposition can significantly contribute to the ADC calibration procedure performed on the production line in term of integral and differential nonlinearity. This is backgrounded by the fact that the knowledge of ADC performance contributors provided by the proposed method helps to adjust the values of on-chip converter components so as to equalize (and possibly minimize) the total non-linearity error. In this paper, the design evaluation procedure is demonstrated on a system design example of pipelined A/D converter. Significant simulation results of each stage of the design evaluation process are given, starting from the INL performance extraction proceeded in a powerful Virtual Testing Environment implemented in Maple™ software and finishing by an error source simulation, modeling of pipelined ADC structure and determination of error source contribution, suitable for a generic process flow
High Voltage CMOS Control Interface for Astronomy - Grade Charged Coupled Devices
The Pan-STARRS telescope consists of an array of smaller mirrors viewed by a
Gigapixel arrays of CCDs. These focal planes employ Orthogonal Transfer CCDs
(OTCCDs) to allow on-chip image stabilization. Each OTCCD has advanced logic
features that are controlled externally. A CMOS Interface Device for High
Voltage has been developed to provide the appropiate voltage signal levels from
a readout and control system designated STARGRASP. OTCCD chip output levels
range from -3.3V to 16.7V, with two different output drive strenghts required
depending on load capacitance (50pF and 1000pF), with 24mA of drive and a rise
time on the order of 100ns. Additional testing ADC structures have been
included in this chip to evaluate future functional additions for a next
version of the chip.Comment: 13 pages, 17 gigure
A Framework for Evaluating Security in the Presence of Signal Injection Attacks
Sensors are embedded in security-critical applications from medical devices
to nuclear power plants, but their outputs can be spoofed through
electromagnetic and other types of signals transmitted by attackers at a
distance. To address the lack of a unifying framework for evaluating the
effects of such transmissions, we introduce a system and threat model for
signal injection attacks. We further define the concepts of existential,
selective, and universal security, which address attacker goals from mere
disruptions of the sensor readings to precise waveform injections. Moreover, we
introduce an algorithm which allows circuit designers to concretely calculate
the security level of real systems. Finally, we apply our definitions and
algorithm in practice using measurements of injections against a smartphone
microphone, and analyze the demodulation characteristics of commercial
Analog-to-Digital Converters (ADCs). Overall, our work highlights the
importance of evaluating the susceptibility of systems against signal injection
attacks, and introduces both the terminology and the methodology to do so.Comment: This article is the extended technical report version of the paper
presented at ESORICS 2019, 24th European Symposium on Research in Computer
Security (ESORICS), Luxembourg, Luxembourg, September 201
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