8,565 research outputs found
Learning and comparing functional connectomes across subjects
Functional connectomes capture brain interactions via synchronized
fluctuations in the functional magnetic resonance imaging signal. If measured
during rest, they map the intrinsic functional architecture of the brain. With
task-driven experiments they represent integration mechanisms between
specialized brain areas. Analyzing their variability across subjects and
conditions can reveal markers of brain pathologies and mechanisms underlying
cognition. Methods of estimating functional connectomes from the imaging signal
have undergone rapid developments and the literature is full of diverse
strategies for comparing them. This review aims to clarify links across
functional-connectivity methods as well as to expose different steps to perform
a group study of functional connectomes
Single camera pose estimation using Bayesian filtering and Kinect motion priors
Traditional approaches to upper body pose estimation using monocular vision
rely on complex body models and a large variety of geometric constraints. We
argue that this is not ideal and somewhat inelegant as it results in large
processing burdens, and instead attempt to incorporate these constraints
through priors obtained directly from training data. A prior distribution
covering the probability of a human pose occurring is used to incorporate
likely human poses. This distribution is obtained offline, by fitting a
Gaussian mixture model to a large dataset of recorded human body poses, tracked
using a Kinect sensor. We combine this prior information with a random walk
transition model to obtain an upper body model, suitable for use within a
recursive Bayesian filtering framework. Our model can be viewed as a mixture of
discrete Ornstein-Uhlenbeck processes, in that states behave as random walks,
but drift towards a set of typically observed poses. This model is combined
with measurements of the human head and hand positions, using recursive
Bayesian estimation to incorporate temporal information. Measurements are
obtained using face detection and a simple skin colour hand detector, trained
using the detected face. The suggested model is designed with analytical
tractability in mind and we show that the pose tracking can be
Rao-Blackwellised using the mixture Kalman filter, allowing for computational
efficiency while still incorporating bio-mechanical properties of the upper
body. In addition, the use of the proposed upper body model allows reliable
three-dimensional pose estimates to be obtained indirectly for a number of
joints that are often difficult to detect using traditional object recognition
strategies. Comparisons with Kinect sensor results and the state of the art in
2D pose estimation highlight the efficacy of the proposed approach.Comment: 25 pages, Technical report, related to Burke and Lasenby, AMDO 2014
conference paper. Code sample: https://github.com/mgb45/SignerBodyPose Video:
https://www.youtube.com/watch?v=dJMTSo7-uF
Quantifying the Statistical Impact of GRAPPA in fcMRI Data with a Real-Valued Isomorphism
The interpolation of missing spatial frequencies through the generalized auto-calibrating partially parallel acquisitions (GRAPPA) parallel magnetic resonance imaging (MRI) model implies a correlation is induced between the acquired and reconstructed frequency measurements. As the parallel image reconstruction algorithms in many medical MRI scanners are based on the GRAPPA model, this study aims to quantify the statistical implications that the GRAPPA model has in functional connectivity studies. The linear mathematical framework derived in the work of Rowe , 2007, is adapted to represent the complex-valued GRAPPA image reconstruction operation in terms of a real-valued isomorphism, and a statistical analysis is performed on the effects that the GRAPPA operation has on reconstructed voxel means and correlations. The interpolation of missing spatial frequencies with the GRAPPA model is shown to result in an artificial correlation induced between voxels in the reconstructed images, and these artificial correlations are shown to reside in the low temporal frequency spectrum commonly associated with functional connectivity. Through a real-valued isomorphism, such as the one outlined in this manuscript, the exact artificial correlations induced by the GRAPPA model are not simply estimated, as they would be with simulations, but are precisely quantified. If these correlations are unaccounted for, they can incur an increase in false positives in functional connectivity studies
A blind deconvolution approach to recover effective connectivity brain networks from resting state fMRI data
A great improvement to the insight on brain function that we can get from
fMRI data can come from effective connectivity analysis, in which the flow of
information between even remote brain regions is inferred by the parameters of
a predictive dynamical model. As opposed to biologically inspired models, some
techniques as Granger causality (GC) are purely data-driven and rely on
statistical prediction and temporal precedence. While powerful and widely
applicable, this approach could suffer from two main limitations when applied
to BOLD fMRI data: confounding effect of hemodynamic response function (HRF)
and conditioning to a large number of variables in presence of short time
series. For task-related fMRI, neural population dynamics can be captured by
modeling signal dynamics with explicit exogenous inputs; for resting-state fMRI
on the other hand, the absence of explicit inputs makes this task more
difficult, unless relying on some specific prior physiological hypothesis. In
order to overcome these issues and to allow a more general approach, here we
present a simple and novel blind-deconvolution technique for BOLD-fMRI signal.
Coming to the second limitation, a fully multivariate conditioning with short
and noisy data leads to computational problems due to overfitting. Furthermore,
conceptual issues arise in presence of redundancy. We thus apply partial
conditioning to a limited subset of variables in the framework of information
theory, as recently proposed. Mixing these two improvements we compare the
differences between BOLD and deconvolved BOLD level effective networks and draw
some conclusions
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