121,214 research outputs found
A machine learning pipeline for discriminant pathways identification
Motivation: Identifying the molecular pathways more prone to disruption
during a pathological process is a key task in network medicine and, more in
general, in systems biology.
Results: In this work we propose a pipeline that couples a machine learning
solution for molecular profiling with a recent network comparison method. The
pipeline can identify changes occurring between specific sub-modules of
networks built in a case-control biomarker study, discriminating key groups of
genes whose interactions are modified by an underlying condition. The proposal
is independent from the classification algorithm used. Three applications on
genomewide data are presented regarding children susceptibility to air
pollution and two neurodegenerative diseases: Parkinson's and Alzheimer's.
Availability: Details about the software used for the experiments discussed
in this paper are provided in the Appendix
Memory-Based Shallow Parsing
We present memory-based learning approaches to shallow parsing and apply
these to five tasks: base noun phrase identification, arbitrary base phrase
recognition, clause detection, noun phrase parsing and full parsing. We use
feature selection techniques and system combination methods for improving the
performance of the memory-based learner. Our approach is evaluated on standard
data sets and the results are compared with that of other systems. This reveals
that our approach works well for base phrase identification while its
application towards recognizing embedded structures leaves some room for
improvement
On-the-fly adaptivity for nonlinear twoscale simulations using artificial neural networks and reduced order modeling
A multi-fidelity surrogate model for highly nonlinear multiscale problems is
proposed. It is based on the introduction of two different surrogate models and
an adaptive on-the-fly switching. The two concurrent surrogates are built
incrementally starting from a moderate set of evaluations of the full order
model. Therefore, a reduced order model (ROM) is generated. Using a hybrid
ROM-preconditioned FE solver, additional effective stress-strain data is
simulated while the number of samples is kept to a moderate level by using a
dedicated and physics-guided sampling technique. Machine learning (ML) is
subsequently used to build the second surrogate by means of artificial neural
networks (ANN). Different ANN architectures are explored and the features used
as inputs of the ANN are fine tuned in order to improve the overall quality of
the ML model. Additional ANN surrogates for the stress errors are generated.
Therefore, conservative design guidelines for error surrogates are presented by
adapting the loss functions of the ANN training in pure regression or pure
classification settings. The error surrogates can be used as quality indicators
in order to adaptively select the appropriate -- i.e. efficient yet accurate --
surrogate. Two strategies for the on-the-fly switching are investigated and a
practicable and robust algorithm is proposed that eliminates relevant technical
difficulties attributed to model switching. The provided algorithms and ANN
design guidelines can easily be adopted for different problem settings and,
thereby, they enable generalization of the used machine learning techniques for
a wide range of applications. The resulting hybrid surrogate is employed in
challenging multilevel FE simulations for a three-phase composite with
pseudo-plastic micro-constituents. Numerical examples highlight the performance
of the proposed approach
Structural Material Property Tailoring Using Deep Neural Networks
Advances in robotics, artificial intelligence, and machine learning are
ushering in a new age of automation, as machines match or outperform human
performance. Machine intelligence can enable businesses to improve performance
by reducing errors, improving sensitivity, quality and speed, and in some cases
achieving outcomes that go beyond current resource capabilities. Relevant
applications include new product architecture design, rapid material
characterization, and life-cycle management tied with a digital strategy that
will enable efficient development of products from cradle to grave. In
addition, there are also challenges to overcome that must be addressed through
a major, sustained research effort that is based solidly on both inferential
and computational principles applied to design tailoring of functionally
optimized structures. Current applications of structural materials in the
aerospace industry demand the highest quality control of material
microstructure, especially for advanced rotational turbomachinery in aircraft
engines in order to have the best tailored material property. In this paper,
deep convolutional neural networks were developed to accurately predict
processing-structure-property relations from materials microstructures images,
surpassing current best practices and modeling efforts. The models
automatically learn critical features, without the need for manual
specification and/or subjective and expensive image analysis. Further, in
combination with generative deep learning models, a framework is proposed to
enable rapid material design space exploration and property identification and
optimization. The implementation must take account of real-time decision cycles
and the trade-offs between speed and accuracy
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