Laser radar tomography--the effects of speckle

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 1991.Vita.Includes bibliographical references (leaves 165-169).by Bradley Thomas Binder.Ph.D

Optics and Quantum Electronics

Contains table of contents for Section 3 and reports on eighteen research projects.Defense Advanced Research Projects Agency/MIT Lincoln Laboratory Contract MDA972-92-J-1038Joint Services Electronics Program Grant DAAH04-95-1-0038National Science Foundation Grant ECS 94-23737U.S. Air Force - Office of Scientific Research Contract F49620-95-1-0221U.S. Navy - Office of Naval Research Grant N00014-95-1-0715MIT Center for Material Science and EngineeringNational Center for Integrated Photonics Technology Contract DMR 94-00334National Center for Integrated Photonics TechnologyU.S. Navy - Office of Naval Research (MFEL) Contract N00014-94-1-0717National Institutes of Health Grant 9-R01-EY11289MIT Lincoln Laboratory Contract BX-5098Electric Power Research Institute Contract RP3170-25ENEC

In Pursuit of an Optimum Optical Imaging Technology for Early Detection of Dental Caries

Clinical caries detection techniques, such as radiographs, are not sensitive to detect and monitor the progression of caries at early stages. In recent years, several optics-based imaging modalities have been proposed for early detection of caries. In this thesis, we report on a systemic comparative study on the performances of optical coherence tomography and thermophotonic lock-in imaging (TPLI) as early caries detection imaging modalities based on light scattering and absorption, respectively. Through controlled demineralization on extracted human teeth, our results suggest that TPLI provides better sensitivity and detection threshold in detecting early stages of caries. The outcome justifies the need for a light-absorption based imaging modality to produce depth-resolved images. Therefore, preliminary imaging studies on a 3-D imaging platform known as a Truncated-Correlation Photothermal Coherence Tomography (TC-PCT) system was conducted to achieve optimal diagnostic yield. The results demonstrate that TC-PCT can detect early caries with significant enhancement in depth-resolution

High-resolution transport-of-intensity quantitative phase microscopy with annular illumination

For quantitative phase imaging (QPI) based on transport-of-intensity equation (TIE), partially coherent illumination provides speckle-free imaging, compatibility with brightfield microscopy, and transverse resolution beyond coherent diffraction limit. Unfortunately, in a conventional microscope with circular illumination aperture, partial coherence tends to diminish the phase contrast, exacerbating the inherent noise-to-resolution tradeoff in TIE imaging, resulting in strong low-frequency artifacts and compromised imaging resolution. Here, we demonstrate how these issues can be effectively addressed by replacing the conventional circular illumination aperture with an annular one. The matched annular illumination not only strongly boosts the phase contrast for low spatial frequencies, but significantly improves the practical imaging resolution to near the incoherent diffraction limit. By incorporating high-numerical aperture (NA) illumination as well as high-NA objective, it is shown, for the first time, that TIE phase imaging can achieve a transverse resolution up to 208 nm, corresponding to an effective NA of 2.66. Time-lapse imaging of in vitro Hela cells revealing cellular morphology and subcellular dynamics during cells mitosis and apoptosis is exemplified. Given its capability for high-resolution QPI as well as the compatibility with widely available brightfield microscopy hardware, the proposed approach is expected to be adopted by the wider biology and medicine community.Comment: This manuscript was originally submitted on 20 Feb. 201

Video-Rate Fluorescence Molecular Tomography for Hand-held and Multimodal Molecular Imaging

In the United States, cancer is the second leading cause of death following heart disease. Although, a variety of treatment regimens are available, cancer management is complicated by the complexity of the disease and the variability, between people, of disease progression and response to therapy. Therefore, advancements in the methods and technologies for cancer diagnosis, prognosis and therapeutic monitoring are critical to improving the treatment of cancer patients. The development of improved imaging methods for early diagnosis of cancer and of near real-time monitoring of tumor response to therapy may improve outcomes as well as the quality of life of cancer patients. In the last decade, imaging methods including ultrasound, computed tomography: CT), magnetic resonance imaging: MRI), single photon emission computed tomography: SPECT), and positron emission tomography: PET), have revolutionized oncology. More recently optical techniques, that have access to unique molecular reporting strategies and functional contrasts, show promise for oncologic imaging This dissertation focuses on the development and optimization of a fiber-based, video-rate fluorescence molecular tomography: FMT) instrument. Concurrent acquisition of fluorescence and reference signals allowed the efficient generation of ratio-metric data for 3D image reconstruction. Accurate depth localization and high sensitivity to fluorescent targets were established to depths of \u3e10 mm. In vivo accumulation of indocyanine green dye was imaged in the region of the sentinel lymph node: SLN) following intradermal injection into the forepaw of rats. These results suggest that video-rate FMT has potential as a clinical tool for noninvasive mapping of SLN. Spatial and temporal co-registration of nuclear and optical images can enable the fusion of the information from these complementary molecular imaging modalities. A critical challenge is in integrating the optical and nuclear imaging hardware. Flexible fiber-based FMT systems provide a viable solution. The various imaging bore sizes of small animal nuclear imaging systems can potentially accommodate the FMT fiber imaging arrays. In addition FMT imaging facilitates co-registering the nuclear and optical contrasts in time. In this dissertation, the feasibility of integrating the fiber-based, video-rate FMT system with a commercial preclinical NanoSPECT/CT platform was established. Feasibility of in vivo imaging is demonstrated by tracking a monomolecular multimodal-imaging agent: MOMIA) during transport from the forepaw to the axillary lymph nodes region of a rat. These co-registered FMT/SPECT/CT imaging results with MOMIAs may facilitate the development of the next generation preclinical and clinical multimodal optical-nuclear platforms for a broad array of imaging applications, and help elucidate the underlying biological processes relevant to cancer diagnosis and therapy monitoring. Finally, I demonstrated that video-rate FMT is sufficiently fast to enable imaging of cardiac, respiratory and pharmacokinetic induced dynamic fluorescent signals. From these measurements, the image-derived input function and the real-time uptake of injected agents can be deduced for pharmacokinetic analysis of fluorescing agents. In a study comparing normal mice against mice liver disease, we developed anatomically guided dynamic FMT in conjunction with tracer kinetic modeling to quantify uptake rates of fluorescing agents. This work establishes fiber-based, video-rate FMT system as a practical and powerful tool that is well suited to a broad array of potential imaging applications, ranging from early disease detection, quantifying physiology and monitoring progression of disease and therapies

Elevation and Deformation Extraction from TomoSAR

3D SAR tomography (TomoSAR) and 4D SAR differential tomography (Diff-TomoSAR) exploit multi-baseline SAR data stacks to provide an essential innovation of SAR Interferometry for many applications, sensing complex scenes with multiple scatterers mapped into the same SAR pixel cell. However, these are still influenced by DEM uncertainty, temporal decorrelation, orbital, tropospheric and ionospheric phase distortion and height blurring. In this thesis, these techniques are explored. As part of this exploration, the systematic procedures for DEM generation, DEM quality assessment, DEM quality improvement and DEM applications are first studied. Besides, this thesis focuses on the whole cycle of systematic methods for 3D & 4D TomoSAR imaging for height and deformation retrieval, from the problem formation phase, through the development of methods to testing on real SAR data. After DEM generation introduction from spaceborne bistatic InSAR (TanDEM-X) and airborne photogrammetry (Bluesky), a new DEM co-registration method with line feature validation (river network line, ridgeline, valley line, crater boundary feature and so on) is developed and demonstrated to assist the study of a wide area DEM data quality. This DEM co-registration method aligns two DEMs irrespective of the linear distortion model, which improves the quality of DEM vertical comparison accuracy significantly and is suitable and helpful for DEM quality assessment. A systematic TomoSAR algorithm and method have been established, tested, analysed and demonstrated for various applications (urban buildings, bridges, dams) to achieve better 3D & 4D tomographic SAR imaging results. These include applying Cosmo-Skymed X band single-polarisation data over the Zipingpu dam, Dujiangyan, Sichuan, China, to map topography; and using ALOS L band data in the San Francisco Bay region to map urban building and bridge. A new ionospheric correction method based on the tile method employing IGS TEC data, a split-spectrum and an ionospheric model via least squares are developed to correct ionospheric distortion to improve the accuracy of 3D & 4D tomographic SAR imaging. Meanwhile, a pixel by pixel orbit baseline estimation method is developed to address the research gaps of baseline estimation for 3D & 4D spaceborne SAR tomography imaging. Moreover, a SAR tomography imaging algorithm and a differential tomography four-dimensional SAR imaging algorithm based on compressive sensing, SAR interferometry phase (InSAR) calibration reference to DEM with DEM error correction, a new phase error calibration and compensation algorithm, based on PS, SVD, PGA, weighted least squares and minimum entropy, are developed to obtain accurate 3D & 4D tomographic SAR imaging results. The new baseline estimation method and consequent TomoSAR processing results showed that an accurate baseline estimation is essential to build up the TomoSAR model. After baseline estimation, phase calibration experiments (via FFT and Capon method) indicate that a phase calibration step is indispensable for TomoSAR imaging, which eventually influences the inversion results. A super-resolution reconstruction CS based study demonstrates X band data with the CS method does not fit for forest reconstruction but works for reconstruction of large civil engineering structures such as dams and urban buildings. Meanwhile, the L band data with FFT, Capon and the CS method are shown to work for the reconstruction of large manmade structures (such as bridges) and urban buildings

Development and On-sky Demonstration of Atmospheric Turbulence Profiler for Future Adaptive Optics with Multiple Laser Guide Stars

Tohoku University博士（理学）thesi

Wide-Angle Multistatic Synthetic Aperture Radar: Focused Image Formation and Aliasing Artifact Mitigation

Traditional monostatic Synthetic Aperture Radar (SAR) platforms force the user to choose between two image types: larger, low resolution images or smaller, high resolution images. Switching to a Wide-Angle Multistatic Synthetic Aperture Radar (WAM-SAR) approach allows formation of large high-resolution images. Unfortunately, WAM-SAR suffers from two significant implementation problems. First, wavefront curvature effects, non-linear flight paths, and warped ground planes lead to image defocusing with traditional SAR processing methods. A new 3-D monostatic/bistatic image formation routine solves the defocusing problem, correcting for all relevant wide-angle effects. Inverse SAR (ISAR) imagery from a Radar Cross Section (RCS) chamber validates this approach. The second implementation problem stems from the large Doppler spread in the wide-angle scene, leading to severe aliasing problems. This research effort develops a new anti-aliasing technique using randomized Stepped-Frequency (SF) waveforms to form Doppler filter nulls coinciding with aliasing artifact locations. Both simulation and laboratory results demonstrate effective performance, eliminating more than 99% of the aliased energy