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Genomic Profiling of Childhood Tumor Patient-Derived Xenograft Models to Enable Rational Clinical Trial Design.
Accelerating cures for children with cancer remains an immediate challenge as a result of extensive oncogenic heterogeneity between and within histologies, distinct molecular mechanisms evolving between diagnosis and relapsed disease, and limited therapeutic options. To systematically prioritize and rationally test novel agents in preclinical murine models, researchers within the Pediatric Preclinical Testing Consortium are continuously developing patient-derived xenografts (PDXs)-many of which are refractory to current standard-of-care treatments-from high-risk childhood cancers. Here, we genomically characterize 261 PDX models from 37 unique pediatric cancers; demonstrate faithful recapitulation of histologies and subtypes; and refine our understanding of relapsed disease. In addition, we use expression signatures to classify tumors for TP53 and NF1 pathway inactivation. We anticipate that these data will serve as a resource for pediatric oncology drug development and will guide rational clinical trial design for children with cancer
Privacy-Preserving Facial Recognition Using Biometric-Capsules
Indiana University-Purdue University Indianapolis (IUPUI)In recent years, developers have used the proliferation of biometric sensors in smart devices, along with recent advances in deep learning, to implement an array of biometrics-based recognition systems. Though these systems demonstrate remarkable performance and have seen wide acceptance, they present unique and pressing security and privacy concerns. One proposed method which addresses these concerns is the elegant, fusion-based Biometric-Capsule (BC) scheme. The BC scheme is provably secure, privacy-preserving, cancellable and interoperable in its secure feature fusion design.
In this work, we demonstrate that the BC scheme is uniquely fit to secure state-of-the-art facial verification, authentication and identification systems. We compare the performance of unsecured, underlying biometrics systems to the performance of the BC-embedded systems in order to directly demonstrate the minimal effects of the privacy-preserving BC scheme on underlying system performance. Notably, we demonstrate that, when seamlessly embedded into a state-of-the-art FaceNet and ArcFace verification systems which achieve accuracies of 97.18% and 99.75% on the benchmark LFW dataset, the BC-embedded systems are able to achieve accuracies of 95.13% and 99.13% respectively. Furthermore, we also demonstrate that the BC scheme outperforms or performs as well as several other proposed secure biometric methods
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