1,658 research outputs found

    Undergraduate Catalog of Studies, 2023-2024

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    Graduate Catalog of Studies, 2023-2024

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    Undergraduate Catalog of Studies, 2023-2024

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    MR thermometry for hyperthermia in the head and neck

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    Unlocking cardiac motion: assessing software and machine learning for single-cell and cardioid kinematic insights

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    The heart coordinates its functional parameters for optimal beat-to-beat mechanical activity. Reliable detection and quantification of these parameters still represent a hot topic in cardiovascular research. Nowadays, computer vision allows the development of open-source algorithms to measure cellular kinematics. However, the analysis software can vary based on analyzed specimens. In this study, we compared different software performances in in-silico model, in-vitro mouse adult ventricular cardiomyocytes and cardioids. We acquired in-vitro high-resolution videos during suprathreshold stimulation at 0.5-1-2 Hz, adapting the protocol for the cardioids. Moreover, we exposed the samples to inotropic and depolarizing substances. We analyzed in-silico and in-vitro videos by (i) MUSCLEMOTION, the gold standard among open-source software; (ii) CONTRACTIONWAVE, a recently developed tracking software; and (iii) ViKiE, an in-house customized video kinematic evaluation software. We enriched the study with three machine-learning algorithms to test the robustness of the motion-tracking approaches. Our results revealed that all software produced comparable estimations of cardiac mechanical parameters. For instance, in cardioids, beat duration measurements at 0.5 Hz were 1053.58 ms (MUSCLEMOTION), 1043.59 ms (CONTRACTIONWAVE), and 937.11 ms (ViKiE). ViKiE exhibited higher sensitivity in exposed samples due to its localized kinematic analysis, while MUSCLEMOTION and CONTRACTIONWAVE offered temporal correlation, combining global assessment with time-efficient analysis. Finally, machine learning reveals greater accuracy when trained with MUSCLEMOTION dataset in comparison with the other software (accuracy > 83%). In conclusion, our findings provide valuable insights for the accurate selection and integration of software tools into the kinematic analysis pipeline, tailored to the experimental protocol

    Meta-learning algorithms and applications

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    Meta-learning in the broader context concerns how an agent learns about their own learning, allowing them to improve their learning process. Learning how to learn is not only beneficial for humans, but it has also shown vast benefits for improving how machines learn. In the context of machine learning, meta-learning enables models to improve their learning process by selecting suitable meta-parameters that influence the learning. For deep learning specifically, the meta-parameters typically describe details of the training of the model but can also include description of the model itself - the architecture. Meta-learning is usually done with specific goals in mind, for example trying to improve ability to generalize or learn new concepts from only a few examples. Meta-learning can be powerful, but it comes with a key downside: it is often computationally costly. If the costs would be alleviated, meta-learning could be more accessible to developers of new artificial intelligence models, allowing them to achieve greater goals or save resources. As a result, one key focus of our research is on significantly improving the efficiency of meta-learning. We develop two approaches: EvoGrad and PASHA, both of which significantly improve meta-learning efficiency in two common scenarios. EvoGrad allows us to efficiently optimize the value of a large number of differentiable meta-parameters, while PASHA enables us to efficiently optimize any type of meta-parameters but fewer in number. Meta-learning is a tool that can be applied to solve various problems. Most commonly it is applied for learning new concepts from only a small number of examples (few-shot learning), but other applications exist too. To showcase the practical impact that meta-learning can make in the context of neural networks, we use meta-learning as a novel solution for two selected problems: more accurate uncertainty quantification (calibration) and general-purpose few-shot learning. Both are practically important problems and using meta-learning approaches we can obtain better solutions than the ones obtained using existing approaches. Calibration is important for safety-critical applications of neural networks, while general-purpose few-shot learning tests model's ability to generalize few-shot learning abilities across diverse tasks such as recognition, segmentation and keypoint estimation. More efficient algorithms as well as novel applications enable the field of meta-learning to make more significant impact on the broader area of deep learning and potentially solve problems that were too challenging before. Ultimately both of them allow us to better utilize the opportunities that artificial intelligence presents

    Bayesian inference for challenging scientific models

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    Advances in technology and computation have led to ever more complicated scientific models of phenomena across a wide variety of fields. Many of these models present challenges for Bayesian inference, as a result of computationally intensive likelihoods, high-dimensional parameter spaces or large dataset sizes. In this thesis we show how we can apply developments in probabilistic machine learning and statistics to do inference with examples of these types of models. As a demonstration of an applied inference problem involving a non-trivial likelihood computation, we show how a combination of optimisation and MCMC methods along with careful consideration of priors can be used to infer the parameters of an ODE model of the cardiac action potential. We then consider the problem of pileup, a phenomenon that occurs in astronomy when using CCD detectors to observe bright sources. It complicates the fitting of even simple spectral models by introducing an observation model with a large number of continuous and discrete latent variables that scales with the size of the dataset. We develop an MCMC-based method that can work in the presence of pileup by explicitly marginalising out discrete variables and using adaptive HMC on the remaining continuous variables. We show with synthetic experiments that it allows us to fit spectral models in the presence of pileup without biasing the results. We also compare it to neural Simulation- Based Inference approaches, and find that they perform comparably to the MCMC-based approach whilst being able to scale to larger datasets. As an example of a problem where we wish to do inference with extremely large datasets, we consider the Extreme Deconvolution method. The method fits a probability density to a dataset where each observation has Gaussian noise added with a known sample-specific covariance, originally intended for use with astronomical datasets. The existing fitting method is batch EM, which would not normally be applied to large datasets such as the Gaia catalog containing noisy observations of a billion stars. In this thesis we propose two minibatch variants of extreme deconvolution, based on an online variation of the EM algorithm, and direct gradient-based optimisation of the log-likelihood, both of which can run on GPUs. We demonstrate that these methods provide faster fitting, whilst being able to scale to much larger models for use with larger datasets. We then extend the extreme deconvolution approach to work with non- Gaussian noise, and to use more flexible density estimators such as normalizing flows. Since both adjustments lead to an intractable likelihood, we resort to amortized variational inference in order to fit them. We show that for some datasets that flows can outperform Gaussian mixtures for extreme deconvolution, and that fitting with non-Gaussian noise is now possible

    Graduate Catalog of Studies, 2023-2024

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    Machine learning applications in search algorithms for gravitational waves from compact binary mergers

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    Gravitational waves from compact binary mergers are now routinely observed by Earth-bound detectors. These observations enable exciting new science, as they have opened a new window to the Universe. However, extracting gravitational-wave signals from the noisy detector data is a challenging problem. The most sensitive search algorithms for compact binary mergers use matched filtering, an algorithm that compares the data with a set of expected template signals. As detectors are upgraded and more sophisticated signal models become available, the number of required templates will increase, which can make some sources computationally prohibitive to search for. The computational cost is of particular concern when low-latency alerts should be issued to maximize the time for electromagnetic follow-up observations. One potential solution to reduce computational requirements that has started to be explored in the last decade is machine learning. However, different proposed deep learning searches target varying parameter spaces and use metrics that are not always comparable to existing literature. Consequently, a clear picture of the capabilities of machine learning searches has been sorely missing. In this thesis, we closely examine the sensitivity of various deep learning gravitational-wave search algorithms and introduce new methods to detect signals from binary black hole and binary neutron star mergers at previously untested statistical confidence levels. By using the sensitive distance as our core metric, we allow for a direct comparison of our algorithms to state-of-the-art search pipelines. As part of this thesis, we organized a global mock data challenge to create a benchmark for machine learning search algorithms targeting compact binaries. This way, the tools developed in this thesis are made available to the greater community by publishing them as open source software. Our studies show that, depending on the parameter space, deep learning gravitational-wave search algorithms are already competitive with current production search pipelines. We also find that strategies developed for traditional searches can be effectively adapted to their machine learning counterparts. In regions where matched filtering becomes computationally expensive, available deep learning algorithms are also limited in their capability. We find reduced sensitivity to long duration signals compared to the excellent results for short-duration binary black hole signals
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