Kepler-91b: a planet at the end of its life. Planet and giant host star properties via light-curve variations

The evolution of planetary systems is intimately linked to the evolution of their host star. Our understanding of the whole planetary evolution process is based on the large planet diversity observed so far. To date, only few tens of planets have been discovered orbiting stars ascending the Red Giant Branch. Although several theories have been proposed, the question of how planets die remains open due to the small number statistics. In this work we study the giant star Kepler-91 (KOI-2133) in order to determine the nature of a transiting companion. This system was detected by the Kepler Space Telescope. However, its planetary confirmation is needed. We confirm the planetary nature of the object transiting the star Kepler-91 by deriving a mass of $M_p=0.88^{+0.17}_{-0.33} ~M_{\rm Jup}$ and a planetary radius of $R_p=1.384^{+0.011}_{-0.054} ~R_{\rm Jup}$. Asteroseismic analysis produces a stellar radius of $R_{\star}=6.30\pm 0.16 ~R_{\odot}$ and a mass of $M_{\star}=1.31\pm 0.10 ~ M_{\odot}$. We find that its eccentric orbit ($e=0.066^{+0.013}_{-0.017}$) is just $1.32^{+0.07}_{-0.22} ~ R_{\star}$ away from the stellar atmosphere at the pericenter. Kepler-91b could be the previous stage of the planet engulfment, recently detected for BD+48 740. Our estimations show that Kepler-91b will be swallowed by its host star in less than 55 Myr. Among the confirmed planets around giant stars, this is the planetary-mass body closest to its host star. At pericenter passage, the star subtends an angle of $48^{\circ}$, covering around 10% of the sky as seen from the planet. The planetary atmosphere seems to be inflated probably due to the high stellar irradiation.Comment: 21 pages, 8 tables and 11 figure

Viral population estimation using pyrosequencing

The diversity of virus populations within single infected hosts presents a major difficulty for the natural immune response as well as for vaccine design and antiviral drug therapy. Recently developed pyrophosphate based sequencing technologies (pyrosequencing) can be used for quantifying this diversity by ultra-deep sequencing of virus samples. We present computational methods for the analysis of such sequence data and apply these techniques to pyrosequencing data obtained from HIV populations within patients harboring drug resistant virus strains. Our main result is the estimation of the population structure of the sample from the pyrosequencing reads. This inference is based on a statistical approach to error correction, followed by a combinatorial algorithm for constructing a minimal set of haplotypes that explain the data. Using this set of explaining haplotypes, we apply a statistical model to infer the frequencies of the haplotypes in the population via an EM algorithm. We demonstrate that pyrosequencing reads allow for effective population reconstruction by extensive simulations and by comparison to 165 sequences obtained directly from clonal sequencing of four independent, diverse HIV populations. Thus, pyrosequencing can be used for cost-effective estimation of the structure of virus populations, promising new insights into viral evolutionary dynamics and disease control strategies.Comment: 23 pages, 13 figure