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Calculating partial expected value of perfect information via Monte Carlo sampling algorithms
Partial expected value of perfect information (EVPI) calculations can quantify the value of learning about particular subsets of uncertain parameters in decision models. Published case studies have used different computational approaches. This article examines the computation of partial EVPI estimates via Monte Carlo sampling algorithms. The mathematical definition shows 2 nested expectations, which must be evaluated separately because of the need to compute a maximum between them. A generalized Monte Carlo sampling algorithm uses nested simulation with an outer loop to sample parameters of interest and, conditional upon these, an inner loop to sample remaining uncertain parameters. Alternative computation methods and shortcut algorithms are discussed and mathematical conditions for their use considered. Maxima of Monte Carlo estimates of expectations are biased upward, and the authors show that the use of small samples results in biased EVPI estimates. Three case studies illustrate 1) the bias due to maximization and also the inaccuracy of shortcut algorithms 2) when correlated variables are present and 3) when there is nonlinearity in net benefit functions. If relatively small correlation or nonlinearity is present, then the shortcut algorithm can be substantially inaccurate. Empirical investigation of the numbers of Monte Carlo samples suggests that fewer samples on the outer level and more on the inner level could be efficient and that relatively small numbers of samples can sometimes be used. Several remaining areas for methodological development are set out. A wider application of partial EVPI is recommended both for greater understanding of decision uncertainty and for analyzing research priorities
Conditional Transformation Models
The ultimate goal of regression analysis is to obtain information about the
conditional distribution of a response given a set of explanatory variables.
This goal is, however, seldom achieved because most established regression
models only estimate the conditional mean as a function of the explanatory
variables and assume that higher moments are not affected by the regressors.
The underlying reason for such a restriction is the assumption of additivity of
signal and noise. We propose to relax this common assumption in the framework
of transformation models. The novel class of semiparametric regression models
proposed herein allows transformation functions to depend on explanatory
variables. These transformation functions are estimated by regularised
optimisation of scoring rules for probabilistic forecasts, e.g. the continuous
ranked probability score. The corresponding estimated conditional distribution
functions are consistent. Conditional transformation models are potentially
useful for describing possible heteroscedasticity, comparing spatially varying
distributions, identifying extreme events, deriving prediction intervals and
selecting variables beyond mean regression effects. An empirical investigation
based on a heteroscedastic varying coefficient simulation model demonstrates
that semiparametric estimation of conditional distribution functions can be
more beneficial than kernel-based non-parametric approaches or parametric
generalised additive models for location, scale and shape
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